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What Is Mugwort?

Herb related to ragweed used in naturopathic and traditional Chinese medicine

Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, as well as an herbalist and integrative medicine doctor. He operates a private practice in Santa Monica, California.

Verywell / Anastasia Tretiak

Mugwort ( Artemisia vulgaris ) is a flowering plant native to northern Europe, Asia, and parts of North America. The sage-colored plant is commonly used for beer-making but is also thought to prevent or treat health conditions like anxiety, digestion problems, and irregular periods, among others.

The roots, leaves, stems, and blossoms of the mugwort plant are all used in folk medicine to make tinctures, extracts, tonics, teas, powders, and essential oils.

This article describes the medical uses of mugwort as well as the possible risks and side effects. It also offers tips on how to select and use mugwort safely.

Commonly Known As

  • Artemisia
  • Hierba de San Juan
  • Armoise
  • Vulgaris herba
  • Felon herb
  • St. John's herb
  • Chrysanthemum weed
  • Herbe royale

Click Play to Learn More About Mugwort Tea

This video has been medically reviewed by Meredith Bull, ND.

What Is Mugwort Used For?

Many people consider mugwort to be a common weed. This is because the plant spreads aggressively and can take over large parts of a garden. The plant is also related to ragweed and may cause allergies in people allergic to ragweed.

So when it is found in a yard or garden, mugwort is often destroyed. But in certain parts of the world, mugwort is purposely grown to make herbal medicine.

Mugwort was used by marching soldiers in ancient Rome who put the plant in their shoes to relieve aching feet. St. John the Baptist was said to have worn a girdle of mugwort to relieve stomach pain.

Today, mugwort is used for many medical reasons, including:

  • Relieving stress
  • Boosting energy
  • Promoting blood circulation
  • Relieving headaches
  • Supporting liver health
  • Relieving itching
  • Increasing urine output
  • Easing digestion problem
  • Repelling insects
  • Relieving muscle aches
  • Normalizing menstrual cycles

Active Components

The parts of the mugwort plant that grow above the ground are used to make essential oil. Compounds in the oil (including camphor, pinene, and cineole) are said to have potent antioxidant, antibacterial, and antifungal effects.

A chemical called artemisinin is also found in the root, stem, leaves, and blossoms of the mugwort plant. When taken by mouth, artemisinin is said to cause gentle contractions of the uterus, promoting regular periods. In traditional Chinese medicine (TCM), it is also sometimes used to induce labor.

Artemisinin is thought to have anti-cancer properties, though this has yet to be proven.

Conditions Treated

To date, there is little scientific poor that mugwort can prevent or treat any medical condition. Even so, it is regularly used for people with:

  • Amenorrhea (irregular or absent periods)
  • Anxiety
  • Chronic fatigue
  • Colic
  • Constipation
  • Depression
  • Eczema
  • Diarrhea
  • Epilepsy
  • Headaches and migraines
  • Insomnia
  • Nausea or vomiting

In traditional Chinese medicine, mugwort is also used in the practice of moxibustion . Moxibustion involves rolling mugwort into sticks or cones, igniting it, and waving it over the part of the body being treated. This is thought to enhance the effects of acupuncture.

A 2012 review published in the American Journal of Obstetrics and Gynecology suggested that moxibustion can aid in the delivery of breech babies, reducing the need for cesarean sections. Further research is needed.


Mugwort is thought to treat anxiety, constipation, diarrhea, epilepsy, eczema, headaches, insomnia, and irregular periods, among other health conditions. It is also used in the practice of moxibustion to enhance the effects of acupuncture. There is little evidence that mugwort can prevent or treat any illness.

Possible Side Effects

Mugwort is considered safe more most people but should not be used in those who are pregnant as it may cause the uterus to contract and induce miscarriage. Due to the lack of safety research, mugwort should also not be used in children or people who are breastfeeding.

People with a ragweed allergy should use mugwort with caution due to an increased risk of an allergic reaction.

Mild allergic symptoms to mugwort include:

  • Hives or rash
  • Itching
  • Mouth tingling
  • Swollen lips
  • Headaches
  • Stomach pain
  • Nausea or vomiting

Severe allergic symptoms to mugwort include:

  • Sudden, severe hives or rash
  • Wheezing
  • Coughing
  • Shortness of breath
  • Rapid or irregular heartbeats
  • Swelling of the face, throat, or neck
  • Lightheadedness or fainting

Severe allergic symptoms are signs of a potentially deadly, whole-body allergy known as anaphylaxis . Anaphylaxis is a medical emergency that can lead to shock and death if not treated immediately.

People allergic to celery, birch, or carrot should also use mugwort with caution because the herb is linked to “celery-carrot-mugwort-spice syndrome." This is typically a milder allergy but one that can cause anaphylaxis in rare cases.

A 2008 study from the Netherlands found that 87% of people allergic to celery were also allergic to mugwort, while 52% of those allergic to birch and 26% of those allergic to caraway also had mugwort allergies.


As mugwort is related to ragweed, people with a ragweed allergy may experience an allergic reaction to mugwort as well. Due to the lack of safety research, mugwort should be avoided in children and people who are pregnant or breastfeeding.

Dosage and Preparation

Mugwort is used in cooking to flavor foods and beverages, including fish, meat, desserts, pancakes, soups, salads, and more. Mugwort was used in Europe to flavor beer long before hops were discovered.

Mugwort can be found online and in drugstores, natural food stores, and herbalist shops in many different forms, including:

  • Extracts
  • Tinctures
  • Dried whole leaves
  • Powders
  • Essential oil
  • Supplements (including tablets, capsules, and softgels)

Mugwort can be made into a tea by adding one and a half teaspoons of dried mugwort to a cup of boiling water and steeping for 10 minutes.

There is no recommended dose of mugwort in any form. With that said, mugwort supplements may be safest as the dose is more controlled. As a rule, do not exceed the dose on the product label.


Mugwort is available as a dietary supplement, essential oil, liquid extract, tincture, powder, or whole dried leaves. There is no recommended dose of mugwort.

What to Look For

Keep in mind that herbal remedies and supplements are not strictly regulated by the Food and Drug Administration (FDA).

To better ensure safety, select products that have been certified by the U.S. Pharmacopeia (USF), NSF International, or ConsumerLab. These independent bodies evaluate and report on the purity and safety of natural or herbal supplements like mugwort.

When foraging for mugwort to make essential oil, it is important to harvest the plant when it is just starting to bloom. This is when the flower contains the most potent oil content.


Mugwort is available as a supplement, liquid extract, tincture, essential oil, powder, and whole dried leaves. There is no recommended dose. To ensure purity, opt for brands that have been tested by a third-party certifying body like U.S. Pharmacopeia, NSF International, or ConsumerLab.


Mugwort (Artemisia vulgaris L.) is a plant related to ragweed used as a food flavorant and for herbal medicine. It is thought to boost energy, calm nerves, support digestion, relieve itching and pain, and promote regular periods, among other things. The evidence supporting these claims is lacking.

Mugwort is available as a dietary supplement, tincture, extract, essential oil, powder, or whole dried leaves. It is generally safe for use, although it may cause an allergic reaction in people with ragweed allergies as well as allergies to celery, carrot, or birch. There is no recommended dose.

Mugwort should not be used in children or people who are pregnant or breastfeeding.

A Word From Verywell

Mugwort is considered an invasive species in some geographic areas. In fact, it grows so fast, rapidly taking over gardens and other spaces, that it is illegal to grow in some states. Be sure to check your local and state regulations before cultivating mugwort. There are heavy fines for planting mugwort in some states.

Frequently Asked Questions

Mugwort is a mild psychoactive herb that can alter your senses, Some types of psychoactive herbs may cause hallucinations, but it's unlikely with mugwort. You'd have to take in an extreme amount of mugwort to alter your senses enough to hallucinate.

Actually, it could be very dangerous, but more research on the risks is needed. For thousands of years, traditional medicine has used mugwort smoke to treat ailments. It may be smoked like tobacco or burned near the skin. In both forms, the smoke contains chemicals that are cancerous and harmful.

Wormwood is often considered a type of mugwort, but the names are used interchangeably. There are many species of mugwort and many species of wormwood, but they are grouped into one scientific family, the Artemisia genus. Plants are then divided into smaller groups that differ by how they look, where they live, or other traits.


CBD oil may help treat acne due to its anti-inflammatory properties and ability to reduce sebum production. CBD oil prevents sebaceous gland cells from secreting excessive sebum.


Among the top uses of CBD is to manage chronic pain diseases like arthritis. Over the counter pain killers have harmful effects such as liver damage and are thus unsuitable for prolonged use.


Depression affects 6% and anxiety affects 18% of the U.S. population. Research shows that CBD oil can help with both. I also reduces the levels of stress and anxiety in those suffering from conditions such as PTSD, social anxiety disorder, and obsessive compulsive disorder.


According to the American Cancer Society, CBD oil can slow growth and spread of some kinds of cancer (in animals). Because it fights oxidative stress and inflammation (and both are linked to cancer) it makes sense that CBD oil could help fight cancer cells.


According to research cannabidiol reduces artery blockage, reduces stress induced cardiovascular response, and can reduce blood pressure. It may also reduce cholesterol.


In a past study on rats, rats with daily CBD uptake healed up to 40% faster than those which didnt. Another study relating to the effects of Cannabidiol on bone healing concluded that ligands found in Cannabidiol regulated bone mass.


Although marijuana use is known to increase appetite and calorie intake, CBD has been linked to lower BMI, less obesity, and reduced chance of diabetes.


CBD has anti-inflammatory properties without many of the pharmaceutical anti-inflammatory drug side effects.


CBD has anti-seizure properties that have been shown to successfully treat drug-resistant children who have epilepsy (with no side effects!). In one study published in the New England Journal of Medicine, CBD decreased frequency of seizures by 23% more than those taking a placebo.


Cannabinoids may relieve symptoms of multiple sclerosis (MS). In a study (open-label) of 66 patients with MS and chronic pain, a combination of CBD and THC reduced pain over 2 years.


When Nothing Else Seems to Work…

When the doctors can’t seem to find a solution and the drugs don’t actually get you better. It’s time to seek a real and natural solution. Nutrition is the most powerful healer.


Looking to purchase CBD oil from trusted suppliers? You can visit our office location in North Tonawanda, New York to buy CBD products. Are you looking to purchase CBD oil online? You can make use of all the links provided below to make your purchase online. Once done, your order will be shipped directly to you.


CBD, also known as Cannabidiol, was discovered in 1940 and it’s one of the 113 chemical compounds (cannabinoids) that can be found in the cannabis plant. It’s a naturally occurring substance that can be mined and mixed with a carrier oil, often coconut or hemp seed to create CBD oil.

Unlike other cannabinoids like tetrahydrocannabinol (THC) found in marijuana, CBD is not psychoactive. It won’t alter your mind or make you high. Getting high is only a sensation that’s occurs with THC. Conversely, CBD is reported to offer a range of health benefits. Medicinal use is the primary reason behind its growing approval and commendation.

At Synergy Nutrition and Wellness, we carry only the highest quality and natural health-related products and nutritional supplements. All of our products are available at our office (though you can also purchase them online) and they’re designed for sale only through healthcare practitioners. Read on to find out more about the benefits of CBD.


CBD promotes general well-being and a healthy state-of-mind. CBD also restores and promotes balance to the endocannabinoid system. This system plays a crucial role in the maintenance of wellness and health throughout the body. Many people who have used CBD found it beneficial and noticed substantial improvements with the following health conditions:

  • Depression and Anxiety
  • Chronic pain
  • Inflammation
  • Epilepsy
  • Stroke
  • Diabetes
  • Cancer
  • Acne and Other Skin Conditions
  • High Blood Pressure
  • Seizures
  • High Blood Sugar
  • High Cholesterol
  • Rheumatoid Arthritis
  • Inflammatory Bowel Disease(IBD)
  • Extreme Anger and Stress
  • Insomnia


As stated earlier, CBD plays a significant role in maintaining wellness and health by ensuring that the endocannabinoid system(ECS) is balanced. If your ECS is healthy, then it becomes easier for the remaining systems in your body to function properly.

The Endocannabinoid system(ECS) was discovered in the year 1992, and since the recognition of sterile surgical technique, ECS has been one of the most significant medical findings. Studies and expositions have made us realize that ECS is virtually like a master control system of all physiology- it helps to prevent disease, aging, and regulation of homeostasis. Even though the exact mechanism behind ECS hasn’t been discovered yet, we’re quite aware that our body system contains more endocannabinoid receptors than any other receptors. It is clear that the ECS is essential to our overall wellbeing and health.

For over four decades, scientists have been able to discover the many health perks of CBD on ECS. At the moment, many people use CBD oil for the management of chronic pains and other long-term health-related issues. A handful of others use CBD as supplements that help to promote and maintain their general mood, wellbeing and stress levels.


Generally, CBD is extracted from the hemp plant. In terms of function, cultivation, and application, hemp is entirely unlike marijuana. But since they’re both from the same species, a lot of people find it particularly difficult to differentiate between the two. In 1970, all cannabis species were classified as Schedule I drugs under a controlled substance and even after 45 years, there seems to be some confusion in differentiating the two plants. Although significant process has been made.

The major difference between hemp and marijuana is the percentage of tetrahydrocannabinol (THC) that is contained in each of them. Marijuana is a strain of cannabis, and it contains high levels of THC (between 5% to 30%), hemp is also cannabis, and it contains a high level of CBD and nearly no THC (less than 0.3%).


Negative. You don’t need a prescription or medical card to buy CBD products. Due to its proven effectiveness, some countries classify CBD as a medication. Conversely, it’s available in the Us but without a prescription.


Recently, CBD oils for cats and dogs became very widespread, and it could be the perfect solution to the needs of your furry companion. ECS can be found in humans and mammals like dogs and cats- a significant reason why many pet owners get substantial results whenever they give CBD oils to their furry friend. Just like humans, the reaction of animals to CBD is dependent on the doses you give them. It’s essential for you to select doses that are appropriate to the size of your pet.


Typically, the noticeable effects of CBD oil will last for about 3 to 4 hours. Nonetheless, CBD will remain in your body for about 1 to 2 days.


Absolutely No. CBD has no known toxicity. It’s recommended that you start taking it in small amounts and then increase the dose gradually until you’re able to achieve your anticipated result.

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using cbd oil for fatigue

Does CBD Make You Tired?

For a clear understanding of the answer to whether or not CBD can make you sleepy, it’s important first to understand how CBD works. Cannabidiol (CBD) is one of the many naturally occurring compounds harvested in cannabis plants proven to exert a long list of health benefits, including a good night’s sleep without concerning side effects.

In this article, we’ll cover the different mechanisms through which CBD interacts with the body to produce its effects, why CBD may make you drowsy or sleepy, and how to use it for better sleep.

What Exactly Is CBD?

CBD belongs to a class of plant-compounds called cannabinoids produced in both hemp and marijuana plants.

Cannabinoids like CBD and THC are found in crystal-like resin trichomes filled with terpenes, fatty acids, wax, and other cannabinoids concentrated on the buds of the cannabis plant.

These compounds interact with a system, aptly named after the plant that led to its discovery, the endocannabinoid system (ECS). The ECS is responsible for maintaining homeostasis, a fancy word for “balance” in the body.

The receptors and messenger molecules, known as cannabinoids, act as modulator for systems regulating vital functions, including: mood, metabolism, stress response, and sleep.

Is CBD Psychoactive?

Unlike its cannabinoid counterpart, THC (tetrahydrocannabinol), CBD is not an intoxicant.

While the two molecules have very similar structures, the THC molecule is better suited to bind to the CB1 receptors in the ECS, concentrated in the central nervous system. One of the many roles of CB1 receptors is in regulating the brain’s pleasure-reward circuit. When activated, the CB1 signals dopamine and serotonin release, which produces a high feeling [1].

CBD, on the other hand, doesn’t readily bind to this receptor. Instead, it inhibits the breakdown of two internally produced cannabinoids (endocannabinoids), anandamide and 2-AG. Anandamide looks very similar structurally to THC’s molecular structure, and its name “ananda” is rooted in the Sanskrit word for “bliss“.

Rather than pushing on the same receptor activation as the bliss molecule and THC, CBD may help in producing a feel-good response by improving the levels of internal cannabinoids in the body and improving the receptors’ ability to bind.

While full spectrum or “whole cannabis plant extract” derived from hemp contains trace amounts of THC (up to 0.3%), it’s an amount so small it’s highly unlikely to result in a high, but can have subtle benefits for improving the overall actions of CBD.

Does CBD Oil Make You Sleepy?

CBD may produce a sense of contentment by slowing the breakdown of anandamide, which may help you feel more relaxed, leading to better sleep. However, this unique interaction simply isn’t enough to produce sedative effects.

Some users report, “CBD makes me sleepy” and reach for CBD oil as a natural sleep aid. Simultaneously, many other users turn to CBD to help them feel more alert and clear-headed. So, does CBD make you sleepy or awake?

Researchers are still looking to understand CBD’s effects and pharmacological pathways fully, but it’s believed that CBD’s interaction in the endocannabinoid system helps to regulate the sleep-wake cycle through its relaxation effect.

Some factors that may influence how taking CBD makes you feel may include:

  • Genetics
  • Lifestyle
  • Dosage
  • Type of CBD oil you’re taking

How Dosage Affects Your CBD Effects

Figuring out your ideal dosage can be tricky as people respond to CBD differently.

If you’re planning on taking CBD and have an underlying health condition, we recommend speaking with your health care practitioner so that they can provide you with better guidance given your condition, medical history, and medication you may be taking.

For those using CBD products recreationally, dosing can be a perplexing field to navigate, and the only way through it is with some experimentation. If you’re new to CBD, always start with lighter doses (as recommended on the label) and gradually build your way over the course of a week until you reach your desired effects. If you jump the gun too quickly with large doses, ingesting CBD products can make you feel slight discomfort.

It may be helpful to record your doses and the effects in a journal or an app on your phone so that you can keep track of the effectiveness of your CBD use.

How Does CBD Make You Sleepy?

How much CBD you take can affect how CBD oil makes you feel.

At high doses, CBD may increase Gamma-Aminobutyric Acid (GABA) activity in the brain.

GABA is a neurotransmitter best known as the break-pedal to the stress response in an overly stimulated central nervous system. GABA in the brain pumps the break on the fight-or-flight response, helping to induce calmness and relaxation that can help you fall asleep [ 2].

For those looking to gain CBD benefits for sleep support, it’s recommended you take higher doses of CBD as you’re winding down for bed. Full spectrum CBD, containing a natural range of cannabinoids (alongside THC and CBD) found in the hemp plant is also known to have stronger effects over CBD isolate.

You can also incorporate other sleep hygiene practices to improve your sleep quality, including:

  • Avoiding screen time in the evenings
  • Avoid caffeine in the afternoon
  • Getting regular exercise in the day, but avoid heavy exercise before bed
  • Set a regular sleep and wake time
  • Set your room temperature to a cooler temperature

How Does CBD Make You More Alert?

CBD at low to medium doses has been shown to support mental alertness. You’ll find some brands on the market, combining CBD with caffeine for a more balanced, less jittery caffeine buzz.

CBD may have effects on a key neurotransmitter that makes us feel tired, adenosine. Adenosine levels in the brain increase as the day ends, so we begin to feel tired and ready for sleep. Caffeine also works on adenosine. When you drink coffee, you block adenosine from connecting to receptors that signal that we’re tired [3]. Rather than blocking adenosine receptors, CBD’s interaction through this pathway is a bit more complex. Some studies suggest that CBD helps to improve the efficiency of adenosine receptors [4].

Another pathway through which CBD may help you feel more alert is through the 5-HT1A serotonin receptor. CBD is suggested to enhance this receptor site’s activation, which is responsible for elevating mood and improving our focus [5].

CBD May Support Better Sleep Quality

CBD itself does not have a direct sedative effect. For many people, falling asleep isn’t the issue, but staying asleep to get deep restorative sleep is.

REM (Rapid Eye Movement) is a cycle of sleep that occurs about 90 minutes after falling asleep. It’s called REM because our eyes move quickly behind the eyelids, and our brains are the most active, undergoing renewal.

As CBD may help slow down the stress response, you’re not as likely to be disturbed from sleep, allowing you to get into the deeper, more restorative sleep phase so that you wake up feeling well-rested and energized in the morning.

How To Choose CBD Oil For Sleep


All CBD oil will be labeled with a concentration of CBD in MG on the package.

It can vary from 500MG per bottle all the way to 12,000MG, so choosing the appropriate potency of CBD oil is essential to getting the desired benefits you seek.

To get the most benefits for sleep support, you may want to consider a high potency of CBD oil so that you can achieve higher doses in smaller amounts of oil. This will be the most cost-effective option over time.

Additional Ingredients

CBD has a broad range of health benefits, mainly because it supports the balance of so many of our vital systems. To steer the benefits of CBD for more targeted use, some brands will include natural ingredients to work alongside CBD.

For sleep support, you may explore outside of CBD oil and try a CBD tea with chamomile or CBD Gummies with melatonin. These ingredients contain compounds that work on similar pathways to help reduce stress and improve sleep quality.

The Side-Effects Of CBD

Countless studies explore the safety of CBD and found that CBD is a safe compound that’s well-tolerated in humans, even in high doses over a long time [5].

However, that’s not to say that CBD is without side-effects. Thankfully, the adverse effects of CBD are short-term, only lasting for as long as the compound remains active in your system ( 3–5 hours). Some of the short term side-effects of CBD include:

  • Drowsiness
  • Lethargy
  • Nausea
  • Vomiting
  • Diarrhea
  • Changes in appetite

Most of these side-effects arise when you’ve taken too much CBD. If you find that CBD makes you drowsy and you don’t want this effect, you may need to adjust your CBD dose.

The Takeaway: Can CBD Help You Sleep?

For some, CBD can make them feel tired or drowsy. For others, CBD is their go-to supplement to support their focus and alertness. The point is that CBD’s diverse effects may produce different results for individuals.

If you’re looking to use CBD to support your sleep, you should take larger doses as CBD has been shown to provide calming and relaxing benefits in higher quantities. This may be enough to help you fall asleep and stay asleep through the night.

Before trying CBD for any underlying condition, always consult with your doctor to reduce the chances of side-effects and medication interactions.


The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.

Can Cannabis or CBD Oil Treat ME (Chronic Fatigue Syndrome)?

Myalgic encephalopathy (ME) is a complex and controversial disorder characterized by chronic symptoms of fatigue that have no apparent cause and are not relived by rest. Although there is very little proven research into the potential for cannabis to treat ME, countless sufferers report feeling subjective relief.

What is ME?

Myalgic encepalopathy (ME) has been known by various names in the decades since it was first described, including myalgic encephalomyelitis, chronic fatigue syndrome (CFS), chronic Epstein-Barr virus (due to the belief that the condition was caused by the Epstein-Barr virus), post-viral fatigue syndrome, and systemic exertion intolerance disease.

As well as feelings of intense, unrelenting physical and mental fatigue and postextertional (post-exercise) malaise, ME may also cause those affected to experience headaches, muscle and joint pain, sore throat, digestive disturbances, swollen lymph nodes, impaired memory and concentration, and depression. Symptoms vary in severity according to the individual, and in some cases can seriously detract from the patient’s quality of life.

Physiologically, ME is strongly associated with inflammation of the brain and spinal cord; this is reflected in the term “encephalomyelitis”. Although, this term is gradually being replaced by “encephalopathy” to reflect generalized dysfunction of the central nervous system. A 2014 study found that patients with ME/CFS exhibited markers of inflammation in certain brain regions that were 45-199% higher than in healthy controls.

What causes ME?

The underlying cause of ME is still unknown, and it’s generally thought that a combination of genetic, environmental, infectious and psychological factors may be involved.

The possibility that viral infections play a role has not been discounted, although it appears the previous belief of the Epstein-Barr virus (which is known to cause mononucleosis or glandular fever) being the underlying cause was in fact incorrect. This is because it isn’t present in all sufferers of the condition (now, the chronic fatigue experienced due to the virus is specifically termed Epstein-Barr chronic fatigue). Also because chronic stress (lasting for six months or more) is believed to play a significant role.

Women make up the majority of ME cases and there appears to be a slightly higher prevalence among Native Americans and African Americans than among white Americans. It also appears there’s a genetic element to its development, as family studies have demonstrated that blood relatives of sufferers are at increased risk of acquiring the disease.

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Full Spectrum Cannabis Oil, CBD Oil, and CBD E-Liquids – What Are the Differences?

Does cannabis use improve symptoms of ME?

Although there are apparently no studies or clinical trials specifically investigating the ability of cannabis to improve symptoms of ME, there are numerous existing patients in U.S. medical states who report experiencing subjective relief from symptoms.

Typically, patients report experiencing relief from disturbed or unrefreshing sleep, joint and muscle pain, depression, and emotional imbalance. Some patients also report that cannabis use actually improves the primary symptom of fatigue, with many of these reports stating that sativa-dominant strains are more effective than indica-dominant.

Again, while there aren’t any specific studies into cannabis’ ability to improve the symptoms of ME, there are abundant studies investigating symptoms common in, but not limited to the condition. These symptoms include disturbed sleep, chronic pain, energy regulation, immune function, and cognitive and emotional disturbances.

Which ME symptoms are most improved by cannabis?

1. Sleep

The potential of cannabis to improve poor sleep is relatively well-established. Various studies have demonstrated that while REM sleep is reduced, deep sleep is increased with cannabis, which may lead to overall greater levels of refreshment in the subject.

2. Pain

Chronic pain is also well-known to be improved with cannabis use. It’s been demonstrated to help with both neuropathic (caused by an injury or dysfunction of the nerve itself) and nociceptive (caused by a factor other than injury to the nerve itself, such as a wound or inflammation in neighbouring tissue) pain.

3. Depression

The potential role of cannabinoids in the treatment of depression and cognitive impairment is controversial, but there are studies that imply that a positive effect could be gained by some patients. This positive effect is likely to depend on dose, regularity and history of use, and genetic and environmental factors.

Depression is thought to respond well to low doses and poorly to high doses of cannabinoid-receptor agonists such as THC. And memory has been shown to be improved with administration of rimonabant, a synthetic CB1-receptor antagonist that last year lost market approval as a weight-loss drug due to serious safety concerns.

Relationship between ME and fibromyalgia

There is such a high rate of ME and fibromyalgia syndrome (FMS) existing together, and so many shared symptoms between them, that many believe it to be the same disease manifesting in slightly different ways between patients. 50-70% of patients diagnosed with FMS also fit the criteria for ME.

It’s thought that the difference in diagnosis stems from physicians classing their patients’ symptoms either as disorders of the muscles and joints (FMS), or of the immune system and due to either external (e.g. viral) or autoimmune causes (ME/CFS).

FMS is a condition characterized by chronic pain in specific areas of the body, and heightened sensitivity to touch and pressure. Sufferers also commonly experience chronic fatigue, muscle and joint pain, cognitive dysfunction, sleep disturbances, and depression. If the two conditions are one and the same, it could be said that FMS is the subtype in which pain is the primary symptom, and that fatigue is the primary symptom in the subtype currently known as ME or CFS.

While there has been a relative shortage of proven research specifically on ME and cannabis, there are a far greater number of studies into FMS and cannabis. Many of these studies have found that cannabis can provide significant subjective relief of various symptoms, including muscle and joint pain, digestive dysfunction, and sleep disturbances.

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How Does Cannabis Help Chronic Skin Conditions?

The endocannabinoid system and ME

There have been a small number of studies investigating the role of the endocannabinoid system (ECS) in the development and progression of ME, and several studies investigating its role in stress and generalized fatigue, and post-viral fatigue conditions. There’s also a relatively abundant number of studies on the ECS and related conditions such as FMS, chronic stress, and multiple sclerosis (which also numbers chronic fatigue among its primary symptoms and is in many ways similar to ME itself).

Essentially, it seems that the common thread underlying ME and chronic stress is inflammation within the brain and the tissues of the central and peripheral nervous system. While inflammation is not generally thought to be a symptom of FMS, that may be changing.

There’s a growing body of evidence suggesting that the reverse may in fact be true, and that inflammation of the fasciae (the sheet of connective tissue that surrounds and encloses muscles and organs within the body) may play a central role in FMS. In multiple sclerosis, inflammation and destruction of the myelin sheaths surrounding the neurons of the brain and central nervous system is the underlying cause.

It has been firmly established that the ECS has a fundamental role to play in the occurrence and management of inflammation, and its involvement in FMS is also well-known. Furthermore, the fact that chronic stress is a major cause of inflammation in the central and peripheral nervous system is also now becoming well understood.

Research into inflammation, the immune system, and ME

An important 2012 study investigated the effect of exercise on gene expression in MS patients and ME patients compared with healthy controls. The study found that genes involved in the expression of metabolite-detecting and adrenergic receptors were increased in ME sufferers, while only certain adrenergic receptors were found to be increased in MS patients.

One adrenergic receptor found to be increased in ME patients was the TRPV1-receptor. The TRPV1-receptor isn’t strictly part of the endocannabinoid system, although it’s been demonstrated on various occasions that its biological mechanisms may be affected by ECS-related activity. It’s also known that the endogenous cannabinoid anandamide is capable of activating it.

The relationship between anandamide, the TRPV-1 receptor and muscle fatigue deserves further investigation. Interestingly, a study conducted in 2010 investigated the potential benefits of regular consumption of high-cocoa, polyphenol-rich chocolate for individuals suffering from CFS, and found that symptoms were improved across the board for the high-cocoa group compared to controls.

Cocoa also contains anandamide, and it is thought that chocolate’s mechanism of action (in supplying subjective feelings of well-being and relaxation) is affected via the TRPV-1 receptor.

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Can Cannabis Help Treat and Possibly Even Prevent Malaria?

Can CBD oil help with ME?

The use of CBD oil is especially important for many patients, since not every country has medicinal cannabis programmes, but most countries do allow the sale of CBD oil. Here too, no studies specifically about CBD for ME have been published, but it’s worth investigating if CBD can help ease some of the symptoms.

We’re seeing some promising results, in that CBD may help with many aspects of fatigue. It may help sufferers:

  • Rest better by reducing anxiety, falling asleep quicker and sleeping longer
  • Get relief from pain and the anxiety that often accompanies chronic pain
  • Avoid or decrease disease and inflammation (which like pain, often accompanies chronic fatigue) thanks to CBD promoting a stronger immune system

Then there are reports of using CBD for chronic fatigue that are exciting and just go to show why it’s so important that more research be done. For example, this case of a boy in Norfolk who’d been basically bed-bound due to severe, chronic fatigue. He couldn’t function normally. He hadn’t been to school in eight years. His body wasn’t growing like it should and his hair had even stopped growing. But after his mom had him start a routine of daily drops of cannabidiol (CBD), he started a miraculous recovery.

Clearly, there is a great deal of work still to be done before our understanding of the relationship between the endocannabinoid system and conditions such as ME is complete. However, it’s certain that the role of the ECS is fundamental to such conditions.


78 thoughts on “Can Cannabis or CBD Oil Treat ME (Chronic Fatigue Syndrome)?”

What type of CBD oil is good for internal scar tissue Had a bowel resection. Now have scar tissue on scar tissue on scar tissue. Scar tissue went over to ovary & ovary hurts.
What brand of CBD oil is good for this?

Thank you for your comment. We are sorry to hear about your situation. As Sensi Seeds is not a medical agency or practitioner, we cannot give any kind of medical advice other than to consult your registered healthcare professional. This article about the potential benefits of medicinal cannabis might be useful for you to show your healthcare provider if they are not familiar with it.

You may also find it helpful to contact a support group for medicinal cannabis patients. In the UK there is the United Patients Alliance, and throughout much of the rest of the world there is NORML, who should be able to put you in touch with a group in your area (search United Patients Alliance or NORML followed by your area name).

These are our pages on medicinal cannabis and medicinal cannabis strains, which you might also find interesting. We do have our own brand CBD products, which are reliably high in quality, but we only sell them as food supplements.

I’m really sorry that I can’t help you further.

With best wishes,

Hello, I would be interested in living with Me/CFS Patients in a THC friendly and cheap country. There is plenty options which I tested already.
Male, single 47 8 years suffering and very experienced in many treatments.
I am looking forward to hear from you

I found this to be a very informative article. I happened onto this site because today is the first day that cannabis is legal in Canada. I’ve been struggling with a moderate case of ME, finally diagnosed six years ago. About forty years ago I had a bout of mono and haven’t been truly well since. I’ve had no treatment of any sort from my GP so I’ve been left to my own devices to figure out what might help to relieve my symptoms. Until now it’s been huge amounts of ibuprophen and rest. Tomorrow I”l be heading to a dispensary! Many thanks.

I came here to learn about the relationship between ME and Cannabis…I stayed because the woman lying on the bed is very attractive : )

I have always been allergic to milk and eggs. I was diagnosed with three different conditions in high school by 3 different doctors: lyme’s disease, chronic fatigue sundrome, fibromyalgia. The antibiotics they prescribed me caused allergic reaction. During my 20’s I had backaches, acne, migraines, insomnia.
It wasn’t until my late 30’s when after I had my 2nd son, that all of this was from gluten intolerance and allergies to rice and potatoes! Seriously. My chiropractor helped me discover this after he commented the aches he would feel after pizza on the weekend. I am a different person now. If I add those foods in my diet, symptoms reappear. The paleo diet has transformed my life.

I have found this all encouraging, l have suffered for a long long time with cfs trying many supplements, it was suggested by my son who came across cbd that l should give this a go, which l am going to try.

Excellent article! Great job on explaining ME, and the benefits of cannabis for it.

This was clearly the most informative article that I have EVER read. I have been sick for 40 years. It took forever for a diagnosis. Cannabis is the ONLY thing that has helped me. Thank you so much.

THCA influence the human endocannabinoid system and not the CB1 receptors. THCA influences the system in contrast to the in-direct effects of THC or CBD after it has been converted to THCA and CBDA in trace amounts during the process of metabolization. THCA affects four functions of the endocannabinoid system:
(a) Releases COX-1,
(b) Inhibits COX-2,
(c) Inhibits TNF-Alpha,
(d) Releases interleukin-10.
THC and CBD are neutrals and neither acidic nor basic, so they and do not have the same effects on the endocannabinoid system as THC Acid or CBD Acid.

Georgia — how much and what type of Cannabis are you taking? I am searching to see if it might help the extreme weakness and anxiety I suffer from. Have to also see if it would interact with Zoloft. Thanks.

Hi Georgia & Denise — I’m also in the Gupta Amygdala Retraining Program. Also suffer from CFS’ extreme weakness. Was wondering about taking some form of Cannabis (not sure which one) and if it had helped anyone with CFS and weakness. I also take Zoloft.

I wonder if anyone has found relief from extreme weakness using Cannabis. If so — in what form and how much, how often. Seems like most people find relief from pain and unrestful sleep.

Hoping Cannabis might (?) help my CFS weakness.

I have this condition of chronic fatigue. What did help me was changing diet to a whole food plant based diet. And far infra red sauna that i use every other day. I am by no means out of the woods but these to changed took me from bedridden to walking more than 10 km per days. However i also experienced severe setbacks when i have overdone things. Will try cannabis in some shape or form.

WOW Jakob — How long did the methods you mention take to help you. I have no ability to have an infra red sauna in my apt. But I do primarily eat a plant based diet.

I am also part of the Gupta Amygdaola Retraining for Advanced CFS program. Centers on catching all the negative thoughts and feelings and creating new “grooves” in our psyches. Also utilizes meditation and some other ways to greatly reduce stress — stress is a major part of CFS.

Denise, I see from the above comment that, as of June 2017 you were involved with the Gupta Amygdaola Retraining for Advanced CFS program. Do you feel that this has still worked for you? I’ve looked at the website: more snake oil or true claims? Thanks.

Very interesting and informative article. I am currently suffering from symptoms which match the symptoms of ME to a T. I got some kind of mild virus about 3 weeks ago and felt the body pain, weakness, and fatigue that is normal for viruses, but those symptoms have not gone away. I missed many days of work and now feel my job could be in jeopardy. I have a fast paced Job which requires me to lift and be on my feet all day. Right now my body and mind cannot handle that type of work. I’ve had many tests done and seen a couple different doctors recently but no clues have come up to what this could be. Whatever this is, it is a very frustrating illness. My symptoms: general fatigue, muscle weakness, muscle pain(primary in calves, thighs, and hamstrings), knee joint pain, and mental fatigue/fogginess. hopefully I have answers soon. Good luck to us all.

Thank you for your comment, I’m sorry to hear about your current condition. I hope you make a full recovery soon!

With best wishes,

Great article! I have FMS AND CFS from effects of chemotherapy and radiation treatment. Had I know. More about CBD 6 years ago…I would have pursued it more. I am angered at the stigma around medical cannibas and saddened that it is not yet a readily acceptable treatment t in our modern world. Having just started 2 weeks on Sativa for day and Indica for night– I say I sleep amazingly with no Morning side-effects. Oh!! My restless leg syndrome is diminished when night time Indica. My day time pain is now very low 2 from a 9; although, I dont know why some days the CFS is harsher than other days. I find that the disabling fatigue is the thing that makes me depressed. I wonder if the fatigue will get better? Would love to know and feel alive again!!

Dear Aum,
That sound great! I am so happy for you that you have seen such relief! Could you let me know how you dose? I have CFS and am starting on 3 %CBD oil.

I know this is an old thread, but has anyone here tried eating fresh (not dried or heated, frozen immediately after harvest and used in a smoothie) cannabis to help with ME/CFS?

Undried flowers are known as “inactive”, but active=psychoactive in that context. I’ve used fresh cannabis and have experienced remarkable health benefits – but it does not get you high.

Fresh/frozen buds are the missing link in our quest to use this plant for medicinal benefit. Forget juicing leaves – the power lies in the cannabinoids, and they are concentrated in mature buds.

Arthritis, depression, pre-diabetes, and for a friend, kidney disease (terminal) have all been 90%+ eradicated by using fresh/frozen buds. The effects have been seen using commercial grade, high-THC buds.

May I so bold as to ask for an article or reply as to the specific strains, cbd / thc, terpenes, and preferred administration as in smoking, edibles, tinctures that are best for ME. I’m trying to self-medicate and am trying to learn as much as I can. When I began I thought it was as simple as sativa/indica, but in a short period of time I’ve learned it’s waaaay more than that if you want to get the most medically accurate form for ME. Thanks for all the info and shedding light! All of this is giving me such hope.

Thank you for your comment, we’re really glad that you are finding useful information on the blog. Unfortunately, as Sensi Seeds is not a medical practice, we are not able to provide any advice relating to medical situations other than to consult your doctor or other licensed medical professional. This article, written specifically for healthcare providers who may not be aware of the many properties of cannabis, may be useful to you in talking with your doctor. You could also try to contact local medicinal cannabis support groups, if you have not already done so. In the UK, there is the United Patients Alliance (you can find them on Facebook) and in the US and EU there are many branches of NORML (google NORML followed by your area name). We hope this is helpful.

It is possible that we will publish a more in-depth article on ME / CFS in the future, especially if there are further scientific studies released that can shed more light on this topic.

With best wishes,

I’m wondering what you have discovered in your personal investigation into working with CBD oil and ME. I’m just starting to look for my husband who’s suffered with ME/CFS for 10 years and I’m overwhelmed. Any discoveries you’ve made may at least narrow the field for me. I’m so grateful for anything you’re able to share.

In Light and Love,

Across the board, from Cleveland Clinic to Stanford papers on ME/CFS, this is one of the best articles I’ve read. Thank you. We need a voice and yours was spot on. <3

Well-written and informative! Thank you!

Is there an indication that CBD oil can help with the extreme weakness of CFS (Chronic Fatigue Syndrome)? That is my most debilitating symptom. AAARGH.

Thank you for your comment. We are sorry to hear about your situation. Unfortunately, as Sensi Seeds is not a medical practice, we are not able to provide any advice relating to medical situations other than to consult your doctor or other licensed medical professional. This article, written specifically for healthcare providers who may not be aware of the many properties of cannabis, may be useful to you in talking with your doctor. You could also try to contact local medicinal cannabis support groups, if you have not already done so. In the UK, there is the United Patients Alliance (you can find them on Facebook) and in the US and EU there are many branches of NORML (google NORML followed by your area name). We hope this is helpful.

With best wishes,

I have been suffering from ME/CFS for over 25 years, and like most others have run into a host of quacks with promised remedies that in desperation I turn to in the hopes of relief. Yoga and meditation help deal with the symptoms but offer no relief from the disease. So l look at the possibility that marijuana might offer relief from the pain, mental fog and loss of sleep.
I live in Canada on the west coast where would I go to get some reliable information and some one to help guide me through this process?

Thank you for your comment. We are sorry to hear about your situation. Unfortunately, as Sensi Seeds is not a medical practice, we are not able to provide any advice relating to medical situations other than to consult your doctor or other licensed medical professional. This article, written specifically for healthcare providers who may not be aware of the many properties of cannabis, may be useful to you in talking with your doctor. You could also try to contact local medicinal cannabis support groups, if you have not already done so. In the UK, there is the United Patients Alliance (you can find them on Facebook) and in Canada, the US and EU there are many branches of NORML (google NORML followed by your area name). We hope this is helpful.

With best wishes,

I would like to get in contact with ME/CFS patients for a living community in a THC friendly and cheap country.
What would you suggest where to start?

I’m afraid I don’t have an answer for your question, but I have posted it and your other comment here so that other people can see it. Do you have a Facebook / other social media group that people could contact you through?

With best wishes,

By now, you must know about Seattle. Legal there. Hasn’t Canada changed their laws ?

Happy I found this!

I had ME and cured it myself or learned to support myself and my body so it could heal, I struggled with it for many years , from i was 19 until i got 27 years old. It got triggered by a mycoplasma infection in my lungs. I got the flue and suddently my longs were shutting down and i almoust got in a coma, after that i got ME. it was a lot of pressure in my life at that time, I got the lung infection 2 weeks before i was taking my final exam, had alot of work to do at school, was under alot of pressure. Were trying to find my way in life, moving out from home for the first time, and starting a new life. The recovering for me was a journay. I huge part of what helped my was changing my diet, nutrition and food has a lot to say, ( i made the change in gentle way with the aproach to help my body, not to try too change it or fix it.) I am a vegetarian and decided to cut out any artifical food that was harming my body. Added healthy fats, and chose to eat organic as much as possible and i also decided to go deeper into myself because i belive that this had to have a root cause and was interested in finding out what that could me. I was not this disease, it was something happening inside of me and i got curious about what it was trying to communicate to me. I began slowly to practice yin yoga and body scanning meditations to see how that made me feel, and that helped me to relax and more connected to my self, at the yoga center i met people who had me and connected to like minded people. That helped me alot it was so nice meet loving people, make new friend and to be able to share this with some who understood what i was going throught and to envestigate and try out differnt stuff to see how that effected the body together. I became curious about my emotions and my belife systems and the way i was thinking. I found out that the fatigue for me was a a huge general description on a lot of resistance that made me feel tired and heavy and under the resistance i found a lot of supressed emotions and feeling i was not counscious of before. It was parts of me that i had burried and were pushing against. a lot of old hurting memories and fears came up and supressed emotions. I was always pushing, forcing my self to be a certain way or trying to better alot of different stuff. The heavyness in my body and mind came from alot of differen things but it was truly a liberation to allow and feel it and learn to be with myself in total new way. I dont know if this the case for you but i have severial friends who had cfs and are healthy today. So there is hope! I will recommend you to watch this video from teal swan on cronic fatigue if you are interested in a deep percpective on a huge factor and catalyst for this condition. I ended up there after alot of different ways of looking at it. Personally i belive after what i have experienced in life that it all begings from an energetic level before it becomes a pysical problem, and another thing i have learned is that the way we aproach the body and ourself is key to healing. My body was never sick it tried to help me,it tried to show me what i was missing in myself that wanted my attention and it showed me how i was being with myself. I learned a totally different way to be with myself and take care of myself that i did not understand when i got sick that i needed. because i was so used to live that way that i could not see it. When i learned to meet my needs and myself in an different way and truly listen it changed alot and today i am dont have cronic fatigue anymore. I wish you the best on your healing journay

I am 24 years old and have been diagnosed with chronic fatigue. Your description of the disease, and the psychological burden you felt matches most of my experience. Thank you for your comment and I will definitely try out yin yoga and see the video.

Have a nice day,

Thank you for your reply. I’m in a position where I may be diagnosed with ME. I have a clinic diagnosis of fibromyalgia which wasn’t correct. Over a year and a half I improved my symptoms greatly. I no longer have pain but struggle with fatigue. I was doing pretty well but now after a terrible episode of stress that exhausted my body I seem to be in the midst of some sort of flare up.

Your message resonated with me. I believe my body can heal and will soon begin energy work to help release the things that cause my chronic stress response and PTSD. My body has been out of balance. My greatest fear is that the specialist I am seeing now will diagnose me with ME because he can’t find anything else wrong with me…these are his words.

I feel like this illness is pushing me to live the way I want to live, a more spiritual existence.

Your words give me hope. Thank you

12-20-2016 // AGE 67 WHITE MALE,




I would like to know if cannabis oil would be effective in treating epstein barr and coxsackie viruses? I have a friend who suffers from both, for which there are no cures.

Thank you for your comment. We are sorry to hear about your friend’s situation. Unfortunately, as Sensi Seeds is not a medical practice, we are not able to provide any advice relating to medical situations other than to consult your doctor or other licensed medical professional. This article, written specifically for healthcare providers who may not be aware of the many properties of cannabis, may be useful to your friend in talking with their doctor. You could also try to contact local medicinal cannabis support groups, if you have not already done so. In the UK, there is the United Patients Alliance (you can find them on Facebook) and in the US there are many branches of NORML (google NORML followed by your area name). We hope this is helpful.

With best wishes,

The most common cause of so called M.E…….. Chronic Fatigue……………… is congenital encephalitis / anaemia.
This is being overlooked by the D.O.H on a very grave scale.
We must stop the labels and diagnose the physical cause.

This is abuse on a grand scale.

Abuse of these individuals is probably the most serious shameful act of betrayal (against women) in the health service.

I went to a workshop where the speaker was the leading researcher in CFS, Fibro, and Irritable Bowel Syndrome. He said they now know that they are all caused by an overactive nervous system and suggests that injesting cannabis in low doses helps with symptoms. He states that injesting rather than smoking, makes it last longer in your system and you should experiment with it to get just enough to help with symptoms, but not enough to get high from it. I use strains which have THC but also have a high amount of CBD. I use a Sativa strain for the daytime and an Indica to help me sleep. My CFS flare ups are milder and less frequent since I started using cannabis to treat my symptoms. I also take Magnesium about 900 mg every day. They say it is proven to help also.
The researcher also said that reducing stress and doing deep breathing exercises also can help, along with not overdoing it on days that you feel healthy.

Thanks Shelly. Do you remember the name of the researcher who did the presentation?

see: “Sisters of the Valley” about CBD Oil, Salve, Tincture
(havent tried it myself yet / still smoking the stuff what helps, even though
would like to give it up and soon will try the salve or oil).

I came down with Chronic Fatigue Syndrome. My doctor acquired a licence. I absolutely found relief; just 2 puffs and I was well for hours.

Now there are new breads of oils, tinctures and seeds for growing cannabis. New research has proven some cannabis plants are better than others.

I would really appreciate knowing the names of these plants, seeds and oils by name.

Can anybody tell me from there knowledge or experience.

Loved this article. So many useful informations! I actually came here researching to make sure using cannabis wouldn’t contribute to my FMS or CFS symptoms and now it seems I need to look into what strain to try and find. Unfortunately I live in a non-progressive state. Maybe some day this country will get with the times.

I came here to research the same info and am now ready to throw all the different meds in the trash that get thrown at me every time I leave the docs office. I agree that plants not pills are the way to go…afterall its just all natural right?

CBD oil definitely helps people feel better. CBD oil with less than 3% THC is considered a dietary supplement and is legal in all 50 states.

Thanks for this article.

I can vouch for cannabis being useful for sleep, chronic pain, and general mood in ME.

Also y experience that higher CBD levels are more therapeutic, and less intoxicating. I suggest that inexperienced medical cannabis users should avoid the high THC content strains to start with.

First try THC : CBD ratios between 0:1 and 1:1. Then, if you want, carefully experiment with increasing the THC.

“The underlying cause of ME is still unknown, and it is generally thought that a combination of genetic, environmental, infectious and psychological factors may be involved.”

That is the broad generic non-specific coverall language which the medical profession uses to characterise almost every unexplained medical problem: ‘It’s probably a combination of everything.’

It really means: ‘We don’t know, but don’t want to appear completely clueless.’

The underlying cause is spirochetes in the blood that can be seen under a dark field microscope magnified x 12. Its the body’s inability to get rid of this bacteria that leaves us in a state of illness, its also a pre-curser to cancer so I was looking at Rick Simpson’s oil to see if it helps

Hi Just wondering what dosage would I have ME 21 yrs Dish Spine fused to neck So please reply with some good advise, I have tried cbd before got so itchy it drove me crazy and stopped WHAT DOSAGE. please help terrible Pain in muscles, headaches, tired,1Day out crash for 2days ,,Fog, DOSAGE Help

P.S. I do have Fibromyalgia and ME – officially diagnosed, along with depression. I used to be able to function with just depression for the most part, but after a car accident and injuries, I developed the chronic pain and fatigue states and my nervous system is not the same anymore.

After giving up cannabis for over a year to see where I was really at with my mental health, I didn’t feel any better – more pain, more depression, more headaches, and could not get myself out of fatigue once it started.

I began experimenting again with small doses (as the come-down from large doses is counter-productive to all my conditions). I find that in the past and in the present, that Sativa helps change my perception on a brain level of the fatigue and I am able to push past mental resistance and physical resistance and get some things done!

HI Cat,
specifically what strain, i have heard ‘durban poison ‘ sativa is energetic. ( I have M.E.). thx,
mostly i need it for the fatigue aspect. -l

Hi cannabis does work ive just made cannabis eliquid it’s magic no swelling or pain its so much better for you than meds.

Your article is awesome and great to read. Medical cannabis is awesome thing and anybody can enjoy its benefits. Even studies and researches also has proven that it works awesomely . Thanks for sharing this article.

“The underlying cause of ME is still unknown, and it is generally thought that a combination of genetic, environmental, infectious and psychological factors may be involved.”

NO. No, it is NOT generally thought that any psychological factors are involved in this disease. That has been solidly disproven, and we who are ill are extraordinarily sick of being told that psychology therapy is a treatment. It is not.

The best that can be hoped for with psychotherapy treatments is a patient being better able to accept their disability – what a sick, sad goal that is.

The Rituximab drug trials are showing that ME is an autoimmune disease. B cell depletion resulted in full cures for some people, once the antibodies cleared from their system. The inflammation is clearly caused by antibodies attacking our own body in some fashion.

Those of us who have ME are often sensitive to certain drugs, or have abnormal reactions to them. Cannabis is not an exception. (This drug makes me inexplicably angry, though passive, and completely unable to focus – not a pleasant experience. And there’s no telling which components caused which effects).

We need a cure, not highly dubious palliative treatments. Your writing skills are better used campaigning for more research funding for this condition, because it remains under-funded and discriminated against.

I recently found out that I have CFS. The things you have mentioned above sounds hopeful to me. Is there any further info/treatment/therapy/diagnosis you know about it?

Unfortunately this is your opinion, Donna. your opinion only. Instead of berating this writer perhaps you should accept that this works for others, though not everyone, such as yourself.
The endocannabinoid system is a proven fact. Good luck to you, but the rest of us will do what works.

I tend to agree with Pd.
Cannabis is helping enormously with my client who has found no help from anything else. The challenge with it is that with so many different strains, and a lack of general medical knowledge by most budtenders… the best you get as advice is to try a lot of different strains and track your responses.

There is a lot to learn about cannabis before blowing it off. For example, I don’t do well with Sativa. I get angry and neurotic. I do well with Indica or Hybrids, but I need to be selective based on my goals. IF inflammation and pain is my primary issue, then I choose a blend or a strain that is suited for that. If stress and fatigue are disturbing, I select a strain known to help with these symptoms. But it’s an experiment for all because of what some call BioIndividuality – a term used to distinguish that all bodies respond differently.
Just like no one diet works for everyone, no one Cannabis strain is perfect for everyone.

Well put Donna. I read these articles with a lot of concern as I have 20 years of experience of dealing with this awful illness and I am sick of charlatans.

Education is the key here! And you appear to be very uneducated on CBD/THC and all the amazing people cultivaring 100’s of strains, Finding the right balance of Thc % to Cbd % is key and the delivery method and quantity all vary from person to person, Your diet is the key to most illnesses and your mental state and mind set are key to everything in life. It is terrible for those who suffer with this infliction so assure me when i say i have sympothy for the suffers i have no sympothy for those who discredit something that has helped millions of people worldwide will all types of conditions, I am not saying it is a cure but i do believe if the right strain and dosage that it will aid many and with far less side affects than pharmicutical drugs. Please do some more research on this before you give your personal opinion and experience as the only outcome. who knows what you consumed and what was in it but nowadays all legitamate medicinal products coming from the THC/CBD industry are all lab tested and provide full chemical analysis and breakdown. I hope you find something to help your symptons and it most definatley could come from the very product you seem to be so against. All the very best to you

Very interesting I have ME for over 12 years and in a relapse at the moment and thinking of trying CBD oil but a bit on sure

my girlfriend has me
and has all the common problems of me
she was refered to an me specialist who reccomended a weeks holiday in a hospital ward and not your normal ward at that
so i took it upon my self to do some research on cannibis oil as my auntie has been diagnosed with cancer
after producing some rick simpson oil from blue cheese cannibis have defo seen changes in both people
my girl friend takes a rice grain of the oil at night at around 7.45 pm
within an hour the she goes to bed because the oil is taking effect
she sleeps all the way through till 6am when the alarm goes off
wakes up great no aches or pain
and nowshe doesnt feel like she has to sleep in the afternoon
so so far so good
shes only been using the oil for one week
only time will tell

My mother suffers from ME and I have RA. I tried CBD oil yesterday for the first time from a friend, and then bought some for myself because I felt like it helped. My mother tried this morning and had her first functional day she’s had in weeks. If it’s legal where you are I suggest trying it. I’m so glad I did

Donna I agree about antibodies attacking our own bodies. I have numerous allergies and one of my most irritating symptoms is intense skin itching. I’ve been on antihistamines for years and I was taking 2 or 3 some days and in the past when it got really badly out of control I’ve taken up to 6 in a day! Before I was given antihistamines I used to scratch my legs until they bled.

I’ve been using CBD oil for around 7 weeks and in that time I’ve only needed 1 antihistamine per day. My itching is vastly reduced; I’ve tried numerous other natural things, including herbs, to try and control it but CBD oil is the only thing that’s helped.

I’m also taking less Cocodamol and most of the time I don’t feel like I need it. I’m hoping I’ll be able to give up both meds completely when I’ve found the right CBD dosage for me; I’m still on a very low dose because I’m taking it slow as is recommended by some people.

CBD also gives me a greater feeling of well being; it feels good and natural, like I’ve been missing it for years!

I’m very interested to read Georgia’s comment. As a 5 year CFS sufferer I too have been dealing with itchy skin for 2 to 3 years with no solution accept that I need to live in Winter permanently ! CBD oil sounds worth a try for me.

Georgia — how much and what type of Cannabis are you taking? I am searching to see if it might help the extreme weakness and anxiety I suffer from. Have to also see if it would interact with Zoloft. Thanks.

Pleas let me know how much cbd oil to take for fibromyalgia and chronic fatigue. Is three times a day enough.

I totally agree that we need to stop saying that there is a psychological component .
I am also tired of reading articles that start by saying that finally X research proves that ME is not psychological. That was proved many,many years ago.

Although this is an interesting and well written article. I too was angered regarding ‘Depression and emotional disturbance is a common feature of ME’ and the references to it having a psychological component. People, understandably, become depressed and anxious, when living with an uncontrollable, fluctuating, severely debilitating illness, that deprives them of living a normal life, causes Horrific suffering on a daily basis, and for which there is no solid treatment for. The psychological impact is the after affect of living with this illness; it is not part of the illness.

Thank you for your article, Donna. I, too, (a sufferer for 37 plus years) am fed up with all the misinformation re: ME and the diagnosing of people who are “tired a lot” as having it. I have had stretches of many years where I was bedridden, unable to tolerate light or sound, barely able to speak and needing to hire people (out of pocket) to do everything, including helping me brush my teeth while lying on my side as I was too weak to stand and/or move my hand up and down more than once or twice. I am very fortunate to have kept positive during the worst of times and have never suffered depression and now am able to go out and appear normal for 7 to 10 hours per week and have more of a normal life. The fact that I will probably die before any help is available is disheartening and I hope that future sufferers have a brighter outlook. Over the years, I have tried many “remedies” that have been suggested and find that some things helped a little for a little while. The only real help has been eliminating as much stress (and movement) from my life as possible and (my apologies to those who are not religious) prayer.

…”Typically, patients report experiencing relief from disturbed or unrefreshing sleep, joint and muscle pain, depression, and emotional imbalance. Some patients also report that cannabis use actually improves the primary symptom of fatigue, with many of these reports stating that sativa-dominant strains are more effective than indica-dominant…” This has been my experience exactly. It helps a lot with the pain, depression, and anxiety associated with this disease. For me it has been a life saver. Thank you for the well written article on this topic.

Hi! I too suffer from ME and haven’t been able to find strains that done make my anxiety go through the roof. I would love to talk about your experience! Can you please email me? Thank you!

Can You Really Use CBD to Boost Your Energy?

I don’t know about you, but I love a good cup of coffee to put a pep in my step to feel more energized.

Are you wondering if CBD can provide similar effects? Several factors play into CBD for energy and productivity including specific products, how you use it, and other lifestyle habits.

If you’re looking to increase energy levels and want to know if CBD can do the trick, it’s important to understand how CBD works in the body and brain. It’s also helpful to know about different types of Cannabidiol products and the best ways to use them.

Continue reading to learn the full scoop on CBD for energy and if it’s really a thing.

Common Reasons Why People Feel Tired or Have Low Energy

Do you find yourself often feeling tired or experiencing low energy levels? It happens to the best of us. Here are some possible reasons why that might be.

  • You skip meals. This can cause your blood sugar to drop which can affect energy levels.
  • You aren’t getting a good night’s sleep . High sleep quality and quantity is crucial.
  • On the other hand, you could be sleeping too much. Excess sleep can interrupt your circadian rhythm making you feel sluggish.
  • You’re taking medication which causes drowsiness.
  • You aren’t exercising enough. Inactivity can lead to feeling more tired than usual.
  • You’re dehydrated. Our bodies are made up of up to 60% water and can’t function properly if we’re lacking it.
  • You have a vitamin deficiency. Eating dairy, vegetables, fish, and whole grains can give your body nutrients that lead to more energy.
  • You could also lack Vitamin D. Exposure to sunlight throughout the day can work wonders.
  • You’re surrounded by clutter. This can deplete your mental energy and cause exhaustion.
  • You have a medical condition such as anxiety, depression, or diabetes. Several conditions can lead to fatigue. If you’re concerned a medical issue could be the cause, contact a healthcare provider.

Can CBD Boost Your Energy?

Our energy levels can be affected by a variety of factors as mentioned above. CBD can work to provide relief in regards to some of these issues which can, in turn, boost your energy.

According to research , CBD can be a wake-promoting agent and it can help people sleep better. Given that a lack of quality sleep naturally leads to low energy levels, using CBD products can lead to increased energy. CBD can also promote alertness by activating neurons in the hypothalamus. When these neurons are activated, dopamine levels are enhanced.

Furthermore, other evidence also shows that CBD can provide a calming effect on the central nervous system. If you’re someone who suffers from anxiety, you know that anxiousness can interrupt sleep and leave you feeling groggy the next day. Since Cannabidiol can relieve anxiety, our bodies have a better chance of getting high-quality rest so that we feel more energized.

How CBD Works in The Body

Our bodies have a complex biological system called the human endocannabinoid system (ECS). The ECS has tiny receptors that help regulate processes in our body such as pain and the immune system. These receptors are known as CB1 and CB2 receptors. The body process receptors are mostly CB2.

When we use CBD, it activates the receptors to balance these processes. When CBD influences these receptors, it’s essentially sending messages to a cell that’s in charge of one of our processes. As a result, our body is able to feel more aligned.

How CBD Affects Your Brain

In the same way that CBD activates CB1 and CB2 receptors in our body, it can do the same in our brain. CB2 receptors are mostly involved in the processes of the brain. When receptors in the brain are activated, disorders such as depression and anxiety can be relieved. In fact, this study showed that CBD affects blood flow in areas of the brain that are typically related to anxiety.

Using CBD can also promote healthy brain cells that can otherwise be affected by things like brain injuries, lifestyle choices, and aging.

Most Effective Ways to Take CBD for Improved Energy and Focus

If you’re looking to take CBD for energy, it’s important to do it with intention so that you can see the benefits you’re hoping for.

Tips for Taking CBD to Boost Energy

Here are some tips to help you along the way if you want to take CBD for energy.

  • Avoid CBD products with THC as this compound can lead to drowsiness.
  • Take it before bedtime to help you have a great night’s rest.
  • Use it to alleviate stress or anxiety to avoid a crash in energy.
  • Take it alongside other healthy habits such as eating a balanced diet and exercising regularly.
  • Check the label of CBD products to see if there are unnecessary additives that could potentially cause you to feel sluggish.
  • Purchase products from a company that shares CBD lab results such as the amount of CBD and THC in the product.
  • Take the correct dosage of CBD. This review shows that lower doses of CBD can have an energizing effect while higher doses can have a sedative effect.

Best Products for CBD for Energy and Focus

As CBD products are becoming more popular, there are a variety of ways to take it. From inhalers to edibles, we’re going to share which CBD for energy are the best.

CBD Inhalers

Nasal inhalers provide a convenient way to carry CBD and are great for those who want to use their CBD from anywhere. If you travel a lot or are always on the go, CBD nasal inhalers are perfect for you. CBD nasal inhalers also provide quick effects. Instead of downing an afternoon coffee that can interrupt your sleep, sniff a nasal inhaler to feel ready to finish off the day.

To experience the effects of a CBD nasal inhaler, all you do is breathe it in through your nose. Inhalers use propellants that help you breathe in a specified dose of CBD and other botanical compounds.

BoomBoom CBD Inhalers also contain essential oils that can relieve stress and increase focus.


CBD oil is derived from the hemp plant and is an extract of Cannabis indica or Cannabis sativa. CBD oil is meant to be absorbed quicker than other products and is good for those who don’t prefer capsules, inhalers, or edibles.

Oil tinctures with droppers are a popular way to consume CBD oil. You typically add it to a beverage or under the tongue (sublingually). Keep in mind that there is a distinct taste to CBD oil that many people don’t mind terribly, especially given the benefits.
There are different types of CBD oil:

  • Full-spectrum : consists of all Cannabis plant compounds including THC (to be legal, it must contain .3% THC or less)
  • Broad-spectrum : consists of most Cannabis plant compounds but 0% THC
  • Isolate : consists only of Cannabidiol; 99% CBD and no THC

If you use CBD oil that contains THC, it can cause you to be sleepy. Using a THC-free oil like the BoomBoom CBD Tincture can be a useful CBD for energy as it’s also used to naturally relieve stress. As mentioned earlier, less stress can lead to more energy.

CBD Edibles

As you may have guessed, CBD edibles are a form of cannabis that you can ingest. They’re ideal for those who want a quick and convenient way to consume CBD. Depending on any flavors added, you may or may not taste the CBD.

Like the oils, CBD edibles can also come in full-spectrum, broad-spectrum, and isolate. Again, using a broad-spectrum or isolate edible without THC will help ensure you maintain reasonable levels of energy.

  • CBD candies
  • CBD baked goods
  • CBD chocolates

CBD capsules can also be considered edible. These are gel capsules that are ingested, then dissolve in the stomach. Capsules are great for those who don’t want any taste of CBD. Keep in mind that different factors determine how fast it works – things like weight, diet, metabolism, and tolerance.

CBD Topicals

CBD topicals are products that can be applied directly to the skin. Oftentimes, topicals are applied to relieve pain caused by everyday stress. We know that stress on the body can be physically tiring. Many people use topicals to feel better and in turn feel a boost of energy.

CBD topicals are often made with oils, water, and/or beeswax. They work by interacting with skin receptors to provide relief. They usually start working right away.

  • CBD lotion
  • CBD soap
  • CBD balm
  • CBD roll-on
  • CBD body oil
  • CBD serum

Things to Keep in Mind

We hope now that you have further insight into CBD products and how they work in the body and brain, you feel better about deciding if CBD for energy is right for you.

The first step is to determine why you’re feeling sluggish. Then, using Cannabidiol can be an effective way to help your body feel more aligned. Using a CBD product with high-quality ingredients along with other healthy lifestyle habits can have excellent affects on our overall wellness including our energy levels.

Did you know that CBD might also be a natural healer for those nagging hangovers? Read about it here .

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high quality cbd oil for dogs

Top 3 CBD Brands for Dogs – Reviewed [2020]

It’s hard to watch your dog suffer from chronic pain — which is why so many pet owners are reaching for a bottle of CBD pet oil, or a bag of CBD dog treats to help their animal cope.

CBD blocks pain by targeting inflammation in the joints and hips responsible for conditions such as arthritis. It also works to mute pain signals caused by other health conditions before they reach the brain.

These benefits offer dramatic improvements to your dog’s quality of life.

But not all CBD pet oils are the same.

Many companies are selling low-grade CBD oil and marking it up for being a “specialty pet product.”

Here, we’ll provide a few examples of reputable brands offering top-shelf CBD products for pets, and offer some tips on what to look for when shopping for a CBD brand to use with your dog.

  • Royal CBD – Award Winning, Best CBD Oil Overall
  • Gold Bee – Runner Up, Quality Product at a Good Price
  • Blessed CBD – Potent CBD, But Only Ships to the UK

1. Royal CBD — Editor’s Pick

Royal CBD only recently stepped into the CBD pet space with a brand new CBD pet oil line and a selection of CBD-infused dog treats.

This company already had a large and loyal customer base, so it didn’t take long before these CBD pet products started getting noticed by the public.

You can find Royal CBD products as the number one recommendation on various websites — including LA Weekly, Observer, VentureBeat, Orlando Weekly, SF Examiner, We Be High, and Cleveland Scene.

Royal CBD pet oils come in three potency options to match your animal’s size — 125 mg for small dogs (and cats), 250 mg for medium-sized dogs, and a larger 500 mg CBD oil for large dogs.

These oils are made from the same high-quality, full-spectrum hemp extract the brand is famous for, but come in a dog-friendly bacon flavor instead.

  • Active — for supporting joint and muscle health
  • Calm — for reducing stress and anxiety
  • Hearty — for supporting cardiovascular health and energy levels

2. Gold Bee — Runner-Up

Gold Bee is a newer CBD company. While they don’t have a specific pet range in their lineup yet, the company’s regular CBD oil options are already well-suited for use in dogs.

There are few differences between a dog-specific CBD oil from regular CBD oils. The main difference between the two is the potency. Dogs are much smaller than humans, so it makes sense to use a smaller potency.

Gold Bee sells its oil in three tiers — low-potency (300 mg), medium potency (600 mg), and high potency (1200 mg). Both the 300 and 600 mg bottles are suitable for use with dogs. Stay away from the 1200 mg bottle unless you’ve got a very large dog or have experience using CBD oil with your animal already.

I also recommend you go for the unflavored version of this oil for dogs.

Gold Bee is best known for its high cost to potency ratio — meaning you pay less for a higher quality product. Various media outlets have already acknowledged the brand for the exceptional quality and price of these oils. Just a few examples include CL Tampa, SF Weekly, CityBeat, SA Current, Metro Times, and more.

3. Blessed CBD — The UK’s Best CBD Brand

Blessed CBD is a UK-based brand known for its organic, full-spectrum CBD products.

It’s important to find local CBD brands if you live in the UK because most US-based CBD companies don’t ship to Europe. Blessed CBD, and another local brand, Crush CBD, are the best options to consider if you’re a resident of Europe.

Like Gold Bee, Blessed CBD doesn’t have a specific line of pet products. However, the brand’s 500 mg oil is a popular choice among pet owners living in the United Kingdom. It offers a relatively high potency of CBD per drop, at around 1.5 mg each.

Dog owners may opt for these higher potency oils because they just need to add a couple of drops to their dogs’ food for an effective dose. For small dogs (less than 7 kg), the starting dose of this oil is around three drops. For medium dogs (7 – 20 kg), just 6 – 10 drops, and for large dogs (over 20 kg), around 15 drops.

This oil is unflavored by default but provides a high concentration of active terpenes. These terpenes offer additional pain and anxiety relief but give the oil a pungent taste. Some dogs don’t like the taste of hemp oil, so using a high potency product allows you to mask the natural hemp flavor from your dog more easily.

Rather than adding a few milliliters of oil, you just need a few drops — making it much less likely for your dog to notice.

Is CBD Safe For Dogs?

CBD is used by tens of thousands of pet owners on their dogs all over the world. It comes publicly recommended by expert veterinarians and has been proven safe in scientific research.

However, that doesn’t mean side effects aren’t possible.

Just like any other health supplement, side effects are more likely to occur if used in higher doses. This is why it’s important to start at a low dose of CBD when first starting, and increasing slowly over time. This is, by far, the easiest way to avoid side effects.

The most common side effects you’re likely to see in your dog are fatigue or lethargy. They may be more sleepy or groggy than usual.

If you notice these side effects, you should reduce the next dose you give them.

More severe side effects may include nausea or vomiting, headaches, dizziness, or skin rashes. Speak with your vet as soon as possible if you notice any side effects aside from fatigue or lethargy.

What’s the Ideal Dose of CBD For Dogs?

The dose of CBD will vary depending on the size of your dog and other factors like your dog’s breed, age, gender, underlying health conditions, and individual genetics.

It’s hard to give a specific dose for every dog because of these variables.

Instead, it’s best to follow the idiom “go low and slow.” This means starting with a dose lower than you think they need, and increasing the dose slowly over time until you find what works for your dog.

  • Small Dogs (under 15 pounds) = 2 mg (add 1 mg per day)
  • Medium-Small Dogs (15 to 30 pounds) = 5 mg (add 2 mg per day)
  • Medium-Large Dogs (30 to 60 pounds) = 10 mg (add 5 mg per day)
  • Large Dogs (over 60 pounds) = 15 mg (add 5 mg per day)

CBD Treats vs. CBD Pet Oils

There are two main ways of using CBD with your dog — CBD pet oils and CBD dog treats.

Each has its own set of pros and cons to consider.

1. Cost

The primary consideration people make when buying CBD pet products is the cost.

In general, CBD dog treats are more expensive than CBD oil. The simple reason is that there’s more that goes into making them. On top of the CBD and carrier oils, you’ve got other herbs or nutrients and the dog treat base.

Oils, on the other hand, require much fewer ingredients and therefore cut down the cost of the product.

You’ll spend roughly 7 cents extra for every milligram of CBD in a dog treat compared to a CBD pet oil.

2. Ease of Use

Both CBD pet treats and CBD oils are easy to use with dogs. You can add CBD oils directly to your dogs’ food.

However, some dogs are particularly picky and will avoid their food if there’s anything different about it (such as being mixed with hemp oil).

In this case, CBD pet treats are an easier option. They’re different from food and don’t have the same association with your dog. They also contain other ingredients your dog will love (such as chicken, beef, or bacon) to mask the hemp’s flavor.

Treats are also easier to calculate doses because they come with a set amount per piece. Compare this with a CBD oil that requires you to first calculate how much volume you need for a dose, and then accurately measure this volume to use with your dog.

3. Potency

Both CBD oils and CBD treats come in a wide range of potencies. You can get dog treats with a dose of CBD as low as 2 mg each, or as high as 30 mg each — and everything in-between.

CBD oils also come in a range of potencies, but the most common are 150, 200, 300, 500, and 1000.

There’s no clear winner in this category as both CBD pols and treats can cover the entire range of potencies.

Key Takeaways: What Are The Top CBD Brands For Dogs?

Millions of pet owners worldwide use CBD to help their dog manage chronic pain, anxiety, stress, digestive health, chronic inflammation, and much more.

The best products to use are CBD pet oils, and CBD dog treats — both work just fine. CBD treats will be a little bit more expensive but may offer the best option for people with picky pets.

When shopping for CBD products for dogs, look for evidence of third-party testing. This is the best way to ensure the claims the company is making are true, and the products are clean and free from harmful contaminants.

One of the best brands to use with your dog is Royal CBD. They offer three different formulas of CBD-infused dog treats and three distinct CBD pet oils to best match your animal’s size.

High quality cbd oil for dogs

CBD oils and CBD-infused dog treats are popular health supplements for dog owners around the world. They’re used to support chronic conditions such as pain, inflammation, anxiety, and much more.

Unfortunately, companies with poor integrity are cashing in on the trend by selling ineffective or potentially unsafe products at a premium to unsuspecting customers.

It’s important to know what to look for in quality CBD pet products, and where to buy products that are worth the money.

Here, we’ll cover the top three CBD pet products for 2020 and offer some tips on what to look for when buying CBD products for dogs.

  • Royal CBD – Award Winning, Best CBD Product For Dogs Overall
  • Gold Bee – Runner Up, Quality Product at a Good Price
  • Blessed CBD – Potent CBD, But Only Ships to the UK

These CBD-infused dog treats come in three different formulas. Each formula is optimized for a specific application or condition:

A) Active Treats — For supporting joint health and mobility. Formulated with turmeric, boswellia, hemp seed, and CBD. Pumpkin-flavored.

B) Calming Treats — To help with anxiety and chronic stress. Formulated with L-theanine, chamomile, hemp seed, and CBD. Peanut butter and apple-flavored.

C) Hearty Treats — For supporting general health and wellbeing. Formulated with blueberries (antioxidant), flaxseed (omega-3 fatty acid), hemp seed, and CBD. Sweet potato and blueberry flavored.

These dog treats have already earned various high-profile mentions from industry experts as one of the best CBD products for dogs. They’re made from a full-spectrum organic hemp extract, use all-natural ingredients and flavorings, and deliver a precise dose of 5 mg per piece.

  • Available in three unique formulas
  • Contains a precise dose of 5 mg to accommodate dogs of all sizes
  • Backed by a 30-day money-back guarantee
  • Only available in the United States (won’t ship internationally)

Gold Bee is a renowned CBD brand in the United States — best known for the exceptionally high concentration of active terpenes.

Terpenes are a vital part of a quality CBD product because they provide additional painkilling, anti-anxiety, and analgesic properties to the oil.

These oils aren’t explicitly marketed towards dogs — but they’re perfectly safe to use with your animal. All Gold Bee CBD oils are non-psychoactive and don’t contain any ingredients that are unsafe for dogs.

  • 300 mg CBD oil — for small dogs (less than 20 lbs)
  • 600 mg CBD oil — for medium dogs (between 20 and 60 lbs)
  • 1200 mg CBD oil — for large dogs (over 60 lbs)

Gold Bee CBD oils have been awarded as one of the best CBD oils by media outlets including SF Examiner, SF Weekly, CityBeat, Weed News, Observer, Orlando Weekly, SA Current, Metro Times, Cleveland Scene, VentureBeat, LA Weekly, and We Be High. They’re considered to provide some of the best value for the money.

  • Excellent cost to potency ratio (excellent value for the money)
  • Made from high-quality organic hemp extract
  • High terpene profiles make these oils stronger than average
  • Increased demand for these oils means they can be out of stock from time to time

3. Blessed CBD Oil — UK’s Best CBD Oil

Blessed CBD is a UK-based CBD company with an impressive range of CBD products to choose from.

The company’s CBD oil is suitable for both humans and their furry companions. They’re made from an organic, full-spectrum hemp extract and hemp seed oil. There are no added flavors or ingredients in this oil that would make them unsafe or unsuitable for dogs.

We’ve included this brand as an option for our UK-based readers because neither of the other companies on our list ship beyond the US border.

Another option to consider if you’re living in the UK or elsewhere in Europe is Crush CBD.

One of the most significant differences to be aware of when using Blessed CBD oils with your dog is the dose. These oils come in a smaller, 10 mL bottle, which means the total CBD is diluted into a smaller volume. The potency of these oils are higher than most CBD oils, so you’ll only need a few drops for a sufficient dose.

  • Made from organic, full-spectrum hemp extracts
  • Independently tested for quality and potency
  • Available in a wide range of potencies to match the size of your dog
  • Only available in the UK

What To Look For When Shopping For CBD Pet Products

There are many high-quality CBD companies to choose from — but there are also quite a few low-quality or scam companies to watch out for as well.

Here are four simple steps you can take to avoid getting ripped off and find a quality CBD brand from the beginning.

1. Check the CBD Potency

The potency of the CBD oil you’re using with your pet is essential. Checking the strength not only ensures you’re getting a real CBD product (as opposed to a hemp seed oil masquerading as a CBD oil), it also ensures you’re using a product that’s suitable for the size of your animal.

The CBD content should always be listed on the bottle. If you see terms like “hemp oil” or “hemp extract,” but no specific mention of the CBD content — keep looking. Many CBD companies operating on marketplaces like Amazon or eBay are selling hemp seed oil and making it look like a CBD oil. Hemp seed contains no active CBD.

  • Small dogs — aim for CBD oils with 300 mg per ounce or less
  • Medium-sized dogs — aim for CBD oils with 600 mg per ounce or less
  • Large dogs — aim for CBD oils with 1200 mg per ounce or less

2. Look for Third-Party Testing

Third-party testing is the only way to prove the contents of a CBD oil match what’s being advertised.

Here’s how these tests work.

A CBD company will produce a batch of hemp extract. The company will then voluntarily send a sample to a testing company with no affiliation with the brand. The testing facility will run a series of tests (depending on what the CBD brand orders) and return the results to the company.

  • Cannabinoid content and profiles
  • Terpene ratios

Contamination testing (pesticides, heavy metals, solvents, microbes)

Once the CBD brand receives the results, they can then choose to keep them secret or post them live on the company website.

Always look for brands that publish these results. This is done to prove the oils or other CBD products are as potent as the company claims — and proves the oils are free from contaminants that can harm your dog’s health.

If a CBD company isn’t posting these results, it leaves us wondering what the company has to hide.

3. What Type of Extract is it?

The type of extract used in a CBD pet product is important too. The best CBD pet products are made from a full-spectrum hemp extract. Many of the other ingredients included in quality hemp oil (terpenes, cannabinoids, sterols, etc.) provide additional support for the oil.

Cannabis terpenes are especially important. Some terpenes work to boost CBD’s effects directly by increasing absorption, decreasing metabolism, and providing specific therapeutic benefits of their own.

If you’re using a CBD isolate product with your pet (contains pure CBD without any additional chemicals), you may want to order some terpene concentrates to boost the oil’s effects.

Terpene concentrates are a cost-effective way to get more out of your CBD oil. You can order various terpenes from companies like Finest Labs.

4. Look For Companies With a Money-Back Guarantee

One of the hallmark signs of a quality CBD brand is a satisfaction guarantee.

Look for companies that stand behind their products by offering to refund the order if it doesn’t live up to your expectations. Most reputable brands will allow you to return the product within 30 days if you’re not completely satisfied.

With that said, it can take time for CBD oils to work with your animals, so it’s important to use the oil for at least a week, and spend some time finding the optimal dose for your animal before deciding the oil doesn’t work.

Key Takeaways: Best CBD Products for Dogs

CBD products are very popular among dog owners these days. They’re primarily used to ease chronic joint pain in aging animals or alleviate separation anxiety or stress in dogs of all ages. However, there are many other applications for CBD products.

If you aim to use CBD products to support a specific condition, it’s important to speak with your vet prior to use. Your vet will be able to cross-reference any other medications or underlying health conditions your dog may have to make sure CBD is safe to use with your dog.

Always look for reputable brands when shopping for CBD products for your pet. Look for signs of third-party testing, quality ingredients, and satisfaction guarantees.

For a quick recommendation, check out the products offered by Royal CBD or Gold Bee. Both brands have already been highly recommended by industry experts and reputable media outlets as the best CBD products for dogs.

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cbd oil for autism 2 yrs old girl

Cannabis for Treating Core and Comorbid Autism Symptoms – Where are we at?

Several new studies published in recent months (first half of 2019) investigated the effects of various cannabis-based medical products (CBMPs) for reducing symptoms of autism. Although all of the studies were open-label and relatively small in scale, the overall results were overwhelmingly positive and encouraging, with statistically significant improvements observed across all measured domains, including social communication, language, and restrictive and repetitive behaviours and interests, the core symptoms of autism.

The biggest positive changes in most of the studies were measured in the domain of so-called ‘challenging behaviours’ and comorbid disorders that are frequently present in autism and that severely affect quality of life of individuals with autism and their families. These included behaviours and difficulties such as aggression and self-harming, anxiety, hyperactivity, lethargy, irritability, stereotypy and inappropriate speech, sensory difficulties, food acceptance, feeding and sleep disorders and seizures.

As all the studies were limited in scope, possible mechanisms were not investigated in most cases. One notable exception was a preliminary investigation by a team at King’s College London, which noted clear effects of cannabidiol (CBD) on brain functional connectivity and brain excitation and inhibition systems in individuals with autism by magnetic resonance spectroscopy and magnetic resonance imaging (Pretzsch et al., 2019, 2019).

This article contains the following chapters:

Cannabis as medicine – a brief overview

The two main species of cannabis genus of plants are Cannabis sativa and Cannabis indica. A cannabis plant contains more than 500 known active compounds–cannabinoids, flavonoids and terpenes, fatty acids and others. The most well-known cannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC), of which only the latter has psychoactive properties. Different strains of the plant are cultivated to contain varying amounts of THC and CBD. Cannabis indica species usually has higher levels of CBD compared to THC, and Cannabis Sativa on average has lower levels of CBD to THC, but there are hundreds of different strains being cultivated of each, and countless hybrid variations. The word ‘hemp’ relates to cannabis plants with in which the levels of THC are very low, usually up to 1%. (At present time the legal limit of THC in hemp oils is 0.2% in the UK and most European countries), while ‘marijuana’ is an unofficial term for strains with high THC content that were originally cultivated primarily for recreational use.

Cannabis has been cultivated in many parts of the world and used as medicine since ancient times. In ancient China it was used to target malaria, rheumatism, constipation, gout and menstrual cramps, and used as a remedy for earache, edema, and inflammation by the ancient Greeks. Since the medieval times practitioners in the West have used cannabis for pain, depression, epilepsy, nausea and vomiting. Around the beginning of the twentieth century over 100 scientific papers had been published in Western medical journals, and medical cannabis preparations were widely used by clinicians and available in local pharmacies.

Recent years have seen renewed research interest and further evidence has accumulated on the therapeutic potential of cannabis—the whole plant extract (sometimes called CBD oil extract, or hemp extract), as well as some of its individual active constituents and their synthetic mimics—in many different conditions.

A growing number of studies points to a major role of the endocannabinoid system (ECS) in human biology. The ECS developed early in evolutionary history and is found in many diverse species. The system comprises of endocannabinoids (natively produced cannabinoids), mediators responsible for their synthesis and metabolism, and the cannabinoid receptors (CRs) that serve as their molecular targets. Endocannabinoids are derivatives of integral components of cellular membranes and act as hydrophobic lipid messengers.

Since CRs are richly expressed throughout the body in various types of tissue and since ECS plays an important regulatory role in many processes, ranging from the regulation of cellular energy metabolism to the modulation of complex cognitive functions, modulating ECS has a great potential for treating a wide range of pathologies, including neurological and neurodegenerative disorders, movement disorders, depression and stress-related disorders, epilepsy, pain, glaucoma, stroke, cancer, inflammation, cardiovascular and metabolic disorders and many others.

At the present time, CBMPs have been approved in several countries for epilepsy, pain management, nausea and spasticity. In many countries clinicians are able to prescribe medical cannabis products off label for numerous conditions including for example Crohn’s disease, ulcerative colitis, Tourette’s Syndrome, post-traumatic stress disorder, glaucoma, migraine and psoriasis, to name a few.

Autism is a qualifying condition for medical cannabis in several US states .

“The cannabis treatment appears to be safe and side effects reported by the patients and parents were moderate and relatively easy to cope with.”
(Bar-Lev Schleider et al. 2019)

A short history of medical cannabis research for autism

One of the first studies on the potential efficacy of medical cannabis for the treatment of autism was a study on 10 patients published in 2006. A cannabis-based medication dronabinol (delta-9-THC) was administered to adolescent patients with autism and intellectual disabilities and self-injurious behaviours (SIB). A significant and lasting improvement in the SIB and overall mood and wellbeing was achieved in 7 out of 10 patients (Kruger and Christophersen 2006). Another case report published in 2010 described significant and lasting improvements in hyperactivity, lethargy, irritability, stereotypy and inappropriate speech in a child with autism after administration of dronabinol (Kurz and Blaas 2010).

Several years later a mixture of CBD:THC was trialled as treatment for autism by a group of Chilean investigators. Several CBD:TCH formulations were given to 20 children over a course of several months, resulting in significant improvements in core symptoms of autism in two thirds of participants. In addition to improving social communication, language, and/or repetitive behaviours, the treatment had a positive effect on sensory difficulties, food acceptance, feeding and sleep disorders, and seizures (Kuester et al. 2017).

In 2018, a brief report on canabidiol-rich cannabis treatment in 60 children with autism, aged between 5-18 years, was published in the Journal of Autism and Developmental Disorders. The formulation used had 20:1 CBD:THC ratio, taken sublingually over 2-4 weeks, with doses up-titrated to effect and tolerability. The treatment led to improvements in behaviour (61%), anxiety (39%) and communication (47%) (Aran et al. 2019).

In 2019, a larger scale retrospective study was published in Nature which analysed data that was collected between 2015 and 2017 as part of the treatment program of 188 ASD patients aged between 5 to 19 years. The treatment was in most cases based on cannabis oil containing 30% CBD and 1.5% THC. After six months of treatment 82.4% of patients (155) were in active treatment and 60.0% (93) had been assessed; 28 patients (30.1%) reported a significant improvement, 50 (53.7%) moderate, 6 (6.4%) slight and only 8 (8.6%) had no change in their condition (Bar-Lev Schleider et al. 2019).

Another study published in 2019 assessed effects of cannabis oil on behaviours, quality of life and comorbidities in 53 children with autism. Cannabinoid oil solution at a concentration of 30% and 1:20 CBD:THC ratio was administered for a median duration of 66 days. The study was open label and used parental reports to assess treatment effects. Improvements were noted in self-injury and rage attacks (67.6%), hyperactivity (68.4%), sleep problems (71.4%) and anxiety (47.1%) (Barchel et al. 2018).

“66,7% of patients had significant improvement according to CGI-I and APSI. Most cases improved at least one of the core symptoms of ASD, including social communication, language, or repetitive behaviors. Additionally, sensory difficulties, food acceptance, feeding and sleep disorders, and/or seizures were improved in most cases. 71,5% of patients received balanced CBD:THC extracts; 19,0%high-CBD; and 9,5% high-THC extracts.”
(Kuester et al. 2017)

Multi-systemic effects of cannabinoids in autism – possible mechanisms of action

The exact mechanisms of effects of CBMPs in patients with autism are not yet fully understood. Findings from various animal models of autism as well as human studies and clinical experience point to dysregulation of ECS in autism, and dysregulated ECS has been proposed a unifying pathophysiology of autism regardless of individual etiology (Debra S Karhson et al. 2018; Brigida et al. 2017; Siniscalco et al. 2013; Zou et al. 2019; Krueger and Brose 2013).

Activation of ECS has been shown to attenuate autism-related symptoms and behaviours and improve cognitive function in both genetic and environmental animal models of autism (Zamberletti, Gabaglio, and Parolaro 2017). Regulating ECS in diverse monogenetic models such as Fmr1, neuroligin and BTBR improves social and cognitive impairments in affected animals (Gomis-González et al. 2016; Speed et al. 2015; Wei et al. 2016). Similarly, cannabidiol treatment reverses neurochemical deficits and abnormal neurodevelopment in environmentally-induced valproic acid (Servadio et al. 2016; Melancia et al. 2018; Zamberletti et al. 2019), immune activation and early inflammation models of autism (Osborne et al. 2019; Doenni et al. 2016).

In addition to the findings from divergent animal models, evidence is emerging of ECS playing an important role in several human disorders with strong links to autism. Improvements in autism-related symptoms following cannabidiol (CBD) administration have been reported in patients with Fragile X Syndrome (FXS) (Tartaglia, Bonn-Miller, and Hagerman 2019). In a recent study a novel transdermal CBD gel formulation produced clinically meaningful reductions in social avoidance, irritability and anxiety symptoms in children and adolescents with FXS (Heussler et al. 2019). In children with tuberous sclerosis complex (TSC), another disorder with extremely high prevalence of autism, treatment with CBD leads to improvements in autism-related symptoms and behaviours. In a recent study on TSC significant positive effects were observed in verbal communication, vocalizations, cognitive availability, and initiation of emotional and physical connections in a large majority of participants irrespective of reduction in seizure activity (Hess et al. 2016).

Observations from clinical settings and parental accounts mirror the results of small trials of CBMPs for autism. Positive clinical results are being reported by clinicians for cases of idiopathic autism with widely different presentation and severity of symptoms.

It is of relevance in this context that a genetic mutation has recently been identified for the first time in a patient presenting with anxiety, mild cognitive dysfunction and early onset autism, which links functional impairments in ECS-linked FAAH2 gene activity with patient’s neurologic and psychiatric symptoms (Sirrs et al. 2015).

ECS is a major regulator of brain development, synaptic plasticity, sensory processing and sensory integration, stress regulation and neuromodulation. It modulates social interactions, including social anxiety and social reward, aggressive behaviours, cognition and memory.

Cannabinoid receptors are present in many organs and types of tissue, including brain and peripheral neurons, the vagus nerve (the central ‘line of communication’ between the gut and the brain), gastrointestinal lining, immune cells, skin, and others. ECS is involved in the modulation of many of the molecular pathways that are altered in autism, such as GABAergic and glutamatergic transmission, immune dysregulation and inflammation, oxidative stress, and altered energy metabolism.

Autism is frequently accompanied by multiple factors that influence severity of symptoms and level of disability of affected individuals such as anxiety, impulsivity and lack of control, agitation and irritability, aggression and self-harming behaviours, depression, cognitive dysfunction, heightened stress response, attention and processing issues, sleep disturbances, immunological and metabolic disturbances, abnormal sensory processing, tics and motor dysfunction.

Rates of nearly all physical health conditions are much higher in autism than in the general population and include gastrointestinal disorders (constipation, reflux, IBD), epilepsy and seizures, migraines, asthma, cancer, immune conditions, obesity, dyslipidemia, hypertension, and diabetes. Rarer conditions, such as movement disorders and Parkinson’s disease are also significantly more common among adults with autism (Alabaf et al. 2019; Croen et al. 2015; Bell, Wittkowski, and Hare 2019).

ECS is known to be affected in many of the conditions that are frequently encountered in autism, and numerous studies have demonstrated the promising effects of various cannabinoids for many of those conditions.

Mechanism of action for the effect of cannabinoids on ASD may possibly involve their effects on: brain signalling and neuronal connectivity; modulation of oxytocin, vasopressin and dopamine signalling; modulation of HPA and stress response; sensory processing; motor functioning; seizures; immunity and inflammation; gastrointestinal function and gut-brain signalling .

“…this study suggests that abnormalities in anandamide activity may underlie the deleterious impact of environmental risk factors on ASD-relevant behaviors, and that the endocannabinoid system may be a therapeutic target for the core and associated symptoms displayed by autistic patients.”
(Servadio et al. 2016)

Cbd oil for autism 2 yrs old girl

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder affecting over 1% of the general population. While it is well established that ASD stems from a combination of genetic and environmental factors, there are no defined mechanisms of pathogenesis, rendering curative therapy very difficult to establish. No effective therapy exists for ASD, presenting an urgent clinical need for better control of common core pathologies of ASD regardless of its etiology. Cannabidiol (CBD), a major phytocannabinoid constituent of the cannabis plant, is gaining significant attention in both the media and in medicine for its antiepileptic, anxiolytic, and antipsychotic properties. Recent anecdotal reports, accumulating preclinical and clinical data, and mechanistic insights suggest that CBD provides a viable treatment opportunity for patients with ASD.

Key words

pathogenesis, Cannabidiol, Autism spectrum disorder (ASD)


Autism spectrum disorder (ASD), often characterized by impaired social interaction and communication, as well as repetitive and stereotypic behaviors, is one of the most common (∼1/64 at births in US) and fastest-growing neurodevelopmental disabilities. The basic symptoms of ASD are often accompanied by other neurological deficits including, but not limited to, anxiety, mood disorder, sleep disturbance, as well as seizures. These medical conditions associated with ASD interact with each other and result in difficulty of any single symptomatic relief of ASD. Many patients must undergo a series of therapies, medications, and clinical visits in an attempt to alleviate some of the symptoms, which often causes economic and personal stress on the patient and their family. For this reason there is urgent clinical need to better manage multiple neurological pathologies of ASD simultaneously, and in so doing improve the quality of life of ASD individuals and their caregivers.

Cannabis has demonstrated its potential for the therapeutic treatment of a variety of ailments and diseases. The naturally grown plant contains over 80 different biochemical compounds called cannabinoids, many of which share very similar chemical structures and active properties [1]. Cannabinoids are often classified into three sub-groups: Phytocannabinoids, endocannabinoids, and synthetic cannabinoids. Phytocannabinoids are the cannabinoids that are found naturally in the cannabis plant, of which cannabidiol (CBD) is the 2 nd most naturally abundant in the plant. CBD has been gaining increasing worldwide attention because of its broad therapeutic potential for providing neuroprotective, anti-inflammatory, antipsychotic, anxiolytic, and anticonvulsant effects in both clinical and preclinical studies [2-8]. Recent anecdotal reports, accumulating animal and human research suggest that CBD provides a viable treatment opportunity for diverse developmental disorders, including ASD. Therefore, CBD holds the potential to simultaneously ameliorate seizures, anxiety, and motor and behavioral deficits that are prevalent in ASD (Figure 1). In an open-label FDA expanded access study, Anderson et al. [9] showed that CBD was not only effective in treating seizures, but also had positive effects on measures of behavior, in a cohort of children with ASD [9].

Figure 1. The beneficial spectrum of CBD provides a strategy for treating ASD pathologies.
Mechanism of action of CBD

Though the mechanism underlying the beneficial effects of CBD is still largely unknown, converging lines of evidence suggest dysregulated cannabinoid signaling likely could play a critical role in the pathophysiology of social functioning deficits in ASD [10]. Unlike psychoactive phytocannabinoid delta-9-tetrahydrocannabinol (THC), CBD displays low affinity but unexpectedly high potency as an antagonist of cannabinoid receptor 1/2 (CB1/CB2) in vitro, which likely accounts for its lack of psychotropic activity [11,12]. Contradictorily, CBD can exhibit an indirect effect on the CB1 receptors by inhibiting the degradation of the endocannabinoid anandamide [13]. However, the broad CNS benefits of CBD are likely a result of its complex pharmacological mechanisms. Besides cannabinoid receptors, CBD also interacts with many other, non-endocannabinoid signaling systems, including the equilibrative nucleoside transporter, the orphan G-protein-coupled receptor GPR55, the transient receptor potential of melastatin type 8 channels, the 5-HT1a receptor, the α3 and α1 glycine receptors, and the transient receptor potential of ankyrin type 1 channel [14]. The multiple mechanistic-targets of CBD make it a unique candidate for treating complex symptoms associated with a number of disorders, including ASD [15].

Anticonvulsant effect of CBD

Epilepsy is common (20-30%) in ASD and is more prevalent in individuals with autistic-like behavior resulting from particular genetic predisposition (e.g. Angelman syndrome, Rett syndrome, Dup15q syndrome, etc.). Animals possessing such genetic modifications also exhibit CNS hyperexcitability, enhanced seizure susceptibility and/or spontaneous recurrent seizures. CBD exhibits potent anti-epileptic features in both clinical and preclinical studies [8,16-21]. Notably, CBD significantly reduced the frequency of total seizures of all types in a recent clinical trial for the treatment of drug-resistant seizures in Dravet syndrome [8]. The antiepileptic mechanisms of CBD are still unclear, but may involve multiple targets [14], which renders it an appealing candidate for complex and refractory epilepsy in ASD. Importantly, the anticonvulsive effects of CBD may be useful in suppressing explosive rage and calming severe anxiety. It is hypothesized that unrecognized partial complex seizures, which cause changes in consciousness but not muscular convulsions, are one source of autistic behavior disturbances [22].

Anxiolytic effect of CBD

Of children with ASD, 40% had at least one comorbid diagnosed anxiety disorder [23], which interacts with and exacerbates the other symptoms of ASD. Anxiety negatively impact quality of life of ASD individuals and is associated with higher health care usage and other social costs [24]. Studies using a wide range of animal models of anxiety suggest an anxiolytic-like effect of CBD [2,4]. Interestingly, CBD reduced general anxiety in a bell-shaped dose-response curve, with anxiolytic effects observed at moderate but not higher doses [25-27]. CBD also alleviated stress-induced anxieties in mice. Acute administration of CBD reduces anxiety induced by restraint, re-exposure to a context that previously paired with foot shocks or predator stress [28-31]. Evidence from human studies also strongly supports the potential for CBD as a treatment for anxiety disorders. CBD reduced anxiety in a group of social anxiety disorder patients and was shown to regulate cerebral blood flow in limbic and paralimbic brain areas [4]. CBD also reduced anxiety induced by simulated public speaking in both healthy volunteers and patients with social anxiety disorders [32,33]. Consistent with animal studies, acute administration of CBD induced anxiolytic effects in healthy subjects with moderate (300 mg), but not lower (100 mg) or higher (900 mg) doses [34]. CBD can also attenuate anxiety related sleep problems. Animal studies revealed microinjection of CBD into the central nucleus of the amygdala blocks repeated combination tests-induced rapid eye movement sleep suppression, probably through its anxiolytic effect [35]. A case study reported CBD decreased anxiety and improved the quality and quantity of sleep of a ten-year-old girl diagnosed with post-traumatic stress disorder (PTSD) [36]. The broad anxiolytic effects of CBD provide a unique treatment opportunity for the diverse anxiety phenotypes in ASD.

Wide-spectrum behavioral benefits of CBD

Animal studies suggest that CBD has a broad spectrum of behavioral benefits. CBD administration was found to rescue reserpine-induced motor and cognitive impairments, normalize MK-801-induced social deficits and hyperactivity, and attenuate THC-induced reduction in social interaction in rats [37-40]. Acute CBD treatment also protected against hippocampal cell death and improved cognition in mouse models of ischemia and cerebral malaria [41,42]. CBD can also reduce learned fear by decreasing fear expression, disrupting memory reconsolidation, and enhancing extinction in contextual fear memory paradigm as shown in a study involving mice [43]. These findings suggest CBD holds therapeutic potentials for ASD-related behavioral abnormalities.

Concluding remarks

Individuals with ASD typically face many challenges that worsen their quality of life, create a host of social and behavioral problems, can force their families into a reduced socioeconomic lifestyle, and potentially increase their risk of death. These individuals and their families currently have no available options to alleviate the devastating toll that this experience can have on them. It is for these reasons that there is a great need to find effective treatment options and explore the safety, efficacy and tolerability, of this promising drug, CBD, for these desperate patients. Establishing, in a preclinical and clinical setting, the quality of life and other daily function changes that CBD could be causing in social behavior, cognition, or motor skills is important. Introduction of CBD into a regular treatment regimen could lead to significant reductions in their otherwise untreatable symptoms. The evaluation of changes examined in sophisticated studies while participants are receiving CBD treatment is an important step in therapeutic testing of the drug and in understanding its potential.

Collectively, the pharmacologically broad-spectrum of CBD covers diverse neurological pathologies of ASD, thereby providing a unique and viable therapeutic opportunity to alleviate multiple core ASD symptoms simultaneously. The increasing interest and attention of its beneficial effects in controlling seizures, behavioral and mood abnormalities in ASD call for systematic preclinical and clinical studies to reveal the mechanisms, efficacy, therapeutic spectrum and safety of CBD in ASD.


I thank Christopher L. Anderson (Department of Biomedical Engineering, University of Florida, United States) for critical discussions and reading of the manuscript.


  1. Mechoulam R, Carlini EA (1978) Toward drugs derived from cannabis. Naturwissenschaften 65: 174-179. [Crossref]
  2. Blessing EM, Steenkamp MM, Manzanares J, Marmar CR (2015) Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics 12: 825-836. [Crossref]
  3. Campos AC, Fogaça MV, Sonegoa AB, Guimarães FS (2016) Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res 112: 119-127. [Crossref]
  4. Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL, et al. (2011) Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol 25: 121-130. [Crossref]
  5. Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (2009) Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30: 515-527. [Crossref]
  6. Zhornitsky S, Potvin S (2012) Cannabidiol in humans-the quest for therapeutic targets. Pharmaceuticals 5: 529-552. [Crossref]
  7. Zuardi AW, Crippa JA, Hallak JEC, Bhattacharyya S, Atakan Z, et al. (2012) A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. Curr Pharm Des 18: 5131-5140. [Crossref]
  8. Devinsky O, Cross JH, Laux L, Marsh E, Miller I, et al. (2017) Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med 376: 2011-2020. [Crossref]
  9. Anderson CL, Evans VF, DeMarse TB, Febo M, Johnson CR, et al. (2017) Cannabidiol for the Treatment of Drug-Resistant Epilepsy in Children: Current State of Research. J Pediatr Neurol 2017(EFirst). [Crossref]
  10. Karhson DS, Hardan AY, Parker KJ (2016) Endocannabinoid signaling in social functioning: an RDoC perspective. Transl Psychiatry 6: e905. [Crossref]
  11. Pertwee RG, The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 153: 199-215. [Crossref]
  12. Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, et al. (2007) Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol 150: 613-623. [Crossref]
  13. Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, et al. (2012) Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry 2: e94. [Crossref]
  14. Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, et al. (2014) Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia 55: 791-802. [Crossref]
  15. Ibeas Bih C, Chen T, Nunn AVW, Bazelot M, Dallas M, et al. (2015) Molecular Targets of Cannabidiol in Neurological Disorders. Neurotherapeutics 12: 699-730. [Crossref]
  16. Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, et al. (2016) Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol 15: 270-278. [Crossref]
  17. Filloux FM (2015) Cannabinoids for pediatric epilepsy? Up in smoke or real science? Transl Pediatr 4: 271-282. [Crossref]
  18. Friedman D, Devinsky O (2015) Cannabinoids in the Treatment of Epilepsy. N Engl J Med 373: 1048-1058. [Crossref]
  19. Jones NA, Glyn SE, Akiyama S, Hill TDM, Hill AJ, et al. (2012) Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure 21: 344-352. [Crossref]
  20. Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O (2015) Cannabinoids and Epilepsy. Neurotherapeutics 12: 747-768. [Crossref]
  21. Verrotti A, Castagnino M, Maccarrone M, Fezza F (2016) Plant-Derived and Endogenous Cannabinoids in Epilepsy. Clin Drug Investig 36: 331-340. [Crossref]
  22. Siri k, Lyons T (2012) Cutting-Edge Therapies for Autism2011-2012. Skyhorse Pub. pp: 82-88. [Crossref]
  23. van Steensel FJ, Bogels SM, Perrin S (2011) Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clin Child Fam Psychol Rev 14: 302-317. [Crossref]
  24. Bodden DH, Bögels SM, Nauta MH, De Haan E, Ringrose J, et al. (2008) Child versus family cognitive-behavioral therapy in clinically anxious youth: an efficacy and partial effectiveness study. J Am Acad Child Adolesc Psychiatry 47: 1384-1394. [Crossref]
  25. Guimaraes FS, Chiaretti TM, Graeff FG, Zuardi AW (1990) Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology (Berl) 100: 558-559. [Crossref]
  26. Onaivi ES, Green MR, Martin BR (1990) Pharmacological characterization of cannabinoids in the elevated plus maze. J Pharmacol Exp Ther 253: 1002-1009. [Crossref]
  27. Zuardi AW, Finkelfarb E , Bueno OF , Musty RE , Karniol IG (1981) Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. Arch Int Pharmacodyn Ther 249: 137-146. [Crossref]
  28. Campos AC, Ferreira FR, Guimaraes FS (2012) Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. J Psychiatr Res 46: 1501-1510. [Crossref]
  29. Granjeiro ÉM, Gomes FV, Guimar&atil2021 Copyright OAT. All rights reservBM (2011) Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress. Pharmacology Biochemistry and Behavior 99: 743-748. [Crossref]
  30. Lemos JI, Resstel LB, Guimaraes FS (2010) Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats. Behav Brain Res 207: 105-111. [Crossref]
  31. Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, et al. (2009) 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol 156: 181-188. [Crossref]
  32. Bergamaschi MM, Queiroz RHC (2011) Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology 36: 1219-1226. [Crossref]
  33. Zuardi AW, Cosme RA, Graeff FG, Guimarães FS (1993) Effects of ipsapirone and cannabidiol on human experimental anxiety. J Psychopharmacol 7: 82-88. [Crossref]
  34. Zuardi AW, Rodrigues NP, Silva AL, Bernardo SA, Hallak JEC, et al. (2017) Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life. Front Pharmacol 8: 259. [Crossref]
  35. Hsiao YT, Yi PL, Li CL, Chang FC (2012) Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. Neuropharmacology 62: 373-384. [Crossref]
  36. Shannon S, Opila-Lehman J (2016) Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report. Perm J 20: 108-111. [Crossref]
  37. Almeida V, Levin R, Peres FF, Niigaki ST, Calzavara MB, et al. (2013) Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test. Prog Neuropsychopharmacol Biol Psychiatry 41: 30-35. [Crossref]
  38. Gururajan A, Taylor DA, Malone DT (2012) Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats. J Psychopharmacol 26: 1317-1332. [Crossref]
  39. Malone DT, Jongejan D, Taylor DA Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. Pharmacol Biochem Behav 93: 91-96. [Crossref]
  40. Peres FF, Levin R, Suiama MA, Diana MC, Gouvêa DA, et al. (2016) Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats. Front Pharmacol 7: 343. [Crossref]
  41. Campos AC, Brant F, Miranda AS, Machado FS, Teixeira AL (2015) Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience 289: 166-180. [Crossref]
  42. Schiavon AP, Soares LM, Bonato JM, Milani H, Guimarães FS, et al. (2014) Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice. Neurotox Res26: 307-316. [Crossref]
  43. Jurkus R, Day HLL, Guimarães FS, Lee JLC, Bertoglio LJ, et al. (2016) Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders. Front Pharmacol 7: 454. [Crossref]
Article Type
Publication history

Received date: June 20, 2017
Accepted date: July 19, 2017
Published date: July 21, 2017


© 2017 Gu B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Gu B (2017) Cannabidiol provides viable treatment opportunity formultipleneurological pathologies of autism spectrum disorder. Glob Drugs Therap 2: DOI: 10.15761/GDT.1000134

Corresponding author
Bin Gu

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA

Controversial Cannabis Treatment Helps 9-Year-Old Boy Speak His First Words

Though Kalel Santiago of Puerto Rico is only 9 years old, he’s already endured some adult-level struggles. At just 10 months, he was diagnosed with the rare childhood cancer neuroblastoma, and spent more than two years undergoing surgery, chemotherapy, and radiation treatments. Then came the next diagnosis: severe, non-verbal autism.

“While he was in the hospital, we noticed he didn’t speak at all and had some behavior that wasn’t right, like hand flapping, and walking on his toes,” his father, Abiel Gomez Santiago, tells Yahoo Parenting from the family’s home in Aguada. “But we waited until he was 3 and cancer-free to look at his behavior.”

He and his wife Gladys — also parents to two older boys, now 18 and 20 — did a cram course in educating themselves on autism. They tried various schools and therapies, and eventually found impressive success with a unique surf-therapy school near their home. Then, through an April fundraising event for that program, the Santiagos happened upon a treatment that would quickly change their lives: hemp oil, rich in the compound cannabidiol (CBD), which has been shown, at least anecdotally, to dramatically ease symptoms of both epilepsy and autism.

They took home the tiny sample bottle of spray and began giving their son twice daily doses, as directed on the label, right into his mouth. And the results, they say, were startling: Kalel started talking — in just two days.

“He surprised us in school by saying the vowels, A-E-I-O-U. It was the first time ever,” Abiel says. “You can’t imagine the emotion we had, hearing Kalel’s voice for the first time. It was amazing. The teacher recorded him and sent it to my wife and me and we said well, the only different thing we have been doing is using the CBD.” Soon thereafter, he adds, Kalel started using consonants to connect his sounds. “He said, ‘amo mi mama,’ ‘I love my mom,’” Abiel says. “I don’t know how to thank [the CBD oil makers].”

Kalel with his parents, Abiel and Gladys.

But the product they are grateful for — Hemp Health, from California, which sells for $40 per ounce (almost a three-month supply) — is not without controversy. It’s just one of many CBD oils now marketed as legally attainable alternatives to the much sought-after Charlotte’s Web — the most popularized version of the oil, which is low in THC and and rich in CBD. But it’s made from specially cultivated marijuana (the cannabis flowers). And since medical marijuana is not legal in all states, especially for minors, scores of desperate families from all over the country have moved to Charlotte’s Web’s source, Colorado. In response, Hemp Health and other versions derived from industrial hemp — THC-free cannabis stalks and seeds — have popped up on the web, claiming to be cheap and legal alternatives.

But the Food and Drug Administration (FDA) would disagree. The agency maintains that such products are unregulated and therefore not proven safe, and that their sale as dietary supplements is in fact illegal. (Though enforcement of such sales, spokesperson Jeff Ventura tells Yahoo Parenting, would depend on factors including “agency resources and the threat to the public health.”) In February, the FDA sent warning letters to many CBD oil manufacturers, telling them to stop making medical claims — like being cure-alls for everything from glaucoma to Ebola — about their products.

In addition, Project CBD, a nonprofit that promotes and educates on the medical uses of CBD, is wary of hemp-derived oils. “[CBD] oils can be effective,” director Martin Lee tells Yahoo Parenting. “We would suggest, however, that anyone who is seeking such products should try to access CBD oil derived from cannabis rather than industrial hemp, which is not an optimal source for CBD.”

Still, what Abiel and Gladys saw that day in the Hemp Health sample was neither threat nor rip-off, but a tiny glimmer of hope. And so far, they say, the results have been nothing short of startling.

Kalel during surf therapy with Dr. Giovanni Martinez.

“He’s been connecting — like he’s awakening to seeing the world,” Abiel says, noting that they have kept up the treatments for just over a month now, and that Kalel continues to make improvements. “He’s looking you in your eyes, he’s been trying to say different things and imitate what we are saying. He’s saying ‘uncle,’ ‘aunt,’ the names of my two kids. It’s something amazing that I cannot explain.” (Regarding the product’s legality, the dad notes, “If we had to go somewhere else to get it, we would. I’d go anywhere.”)

Kalel’s response has shocked others, as well, including his teachers, and even the CBD oil company. “We were really amazed to hear Kalel’s progress, because what they are using is a lower-concentrate product,” Miguel Feliciano, president of Hemp Health’s Puerto Rico distributor, Antonio & Associates, tells Yahoo Parenting. He adds that word of Kalel’s progress has gotten out locally, through the surf-therapy school, Surf4Dem, and that other parents are now asking to try to product.

Kalel’s surf therapist Dr. Giovanni Martinez, a clinical psychologist who has worked with Kalel since Surf4Dem’s inception, has also been stunned by the boy’s change.

“Like his parents, I am also in shock,” he tells Yahoo Parenting. “I never got him to speak, and it was something that was haunting me. Language was something that was missing.” Martinez, who started his surf-therapy school after being inspired by how surfing helped his brother, who has Down syndrome, said he researched the various uses of CBD oil after Gladys asked him about it for Kalel. He told her it was worth a shot. Now he’s cautiously optimistic about how other children may benefit.

“I’m not going to say let’s give this to every kid, because we have to monitor and study it,” Martinez says. “But I am very impressed with his language development. Imagine a mom who has been waiting almost 9 years to hear her child speak?” Though the use of anything cannabis derived continues to be controversial, he believes it is something worth fighting for, given this kind of a result. “To me,” he says, “the story of Kalel is groundbreaking.”

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is cbd oil good for diabetic neuropathy

Medical Marijuana for Diabetic Neuropathy

Diabetic neuropathy is nerve damage caused by recurring high blood pressure glucose. It’s one of the most debilitating and frustrating conditions due to the discomfort, pain, and disability it causes. Many of the available treatments aren’t systematically successful. However, you may find relief from these debilitating symptoms with medical marijuana for diabetic neuropathy.

Diabetic Neuropathy In-Depth

Diabetic neuropathy is a form of damage to your nerves occurring with diabetes. When your glucose (blood sugar) is too high it may damage your body’s nerve fibers. Diabetic neuropathy can also cause damage to the nerves in your feet and legs. Depending on which nerves are damaged, diabetic neuropathy symptoms can range from numbness and pain in your extremities to more severe issues such as:

  • Urinary tract
  • Digestive system
  • Heart
  • Blood vessels

Some patient’s diabetic neuropathy presents only mild symptoms, but for others, the condition can be disabling, painful, and even fatal in some circumstances. Diabetic neuropathy is an extreme case of diabetes complications, but you can slow the progression and possibly prevent it with a healthier lifestyle and blood glucose control.

How Can Medical Marijuana Be an Effective Treatment for Diabetic Neuropathy?

Medical marijuana is a helpful anti-inflammatory therapy and does not pose the same side effects as steroids, which people with diabetes should always avoid. Because arterial inflammation typically occurs throughout a diabetic’s life. Cannabinoids are an excellent way for those who need relief from their pain. Medical cannabis also treats patients with its neuroprotective properties. These neuroprotective properties help protect from inflammatory attacks caused by glycoproteins in the blood.

What Side Effects of Diabetic Neuropathy Can Medical Marijuana Treat?

Medical marijuana used as a diabetic neuropathy treatment can alleviate symptoms such as:

  • Burning
  • Tingling
  • Trouble sleeping
  • Anxiety
  • Depression
  • Neuropathic pain
  • Inflammation

There are cannabinoid receptors throughout your brain, nervous system, and spinal cord on inflammatory cells, according to research. When a patient stimulates these receptors, it leads to decreased inflammation and pain relief.

Best Methods of Marijuana Treatment to Use to Treat Side Effects and Symptoms of Diabetic Neuropathy

Smoke from medical marijuana contains many inorganic and organic chemical compounds that are similar to what you can find in tobacco. When you smoke, it doesn’t matter what you’re smoking; the smoke itself still contains carcinogens in the smoke.

Fortunately, with medical marijuana, you can ingest your marijuana and diabetic neuropathy treatment without having to smoke. Using alternative ways to ingest medical cannabis removes the need to inhale toxic compounds that smoke creates. Therefore, these alternative methods cancel out the respiratory harm connected to smoking. Various methods of medical marijuana for diabetic neuropathy treatment include

  • Inhalation of marijuana (vaporizers are best for inhalation)
  • Concentrated oils
  • Edibles
  • Topicals
  • Suppositories
  • Transdermal patches
  • Sublingual sprays
  • Beverages

Experience Medical Marijuana as an Alternative Treatment Today With Marijuana Care Clinic

If you’re someone who is looking for an alternative treatment for your diabetic neuropathy pain, then a medical marijuana treatment might be the perfect solution for you. Contact Marijuana Care Clinic today and explore and find out how you can start the process of medical marijuana and its’ many benefits.

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cbd roll on oil for headaches

Roll On – Target Roller – 200 MG CBD

Peppermint, copaiba and lavender to the rescue. Our HEADACHE Target Roller combines the ancient powers of essential oils with our premium CBD proven to help relax muscles and alleviate pain. With our Target Roller, you’re empowered to relieve specific tensions. Say hello to your new multipurpose tool, with the unique capability of being applicable to more grounded areas like your wrists, neck and any areas contributing to your pesky headache.

Lab Tested
Within every Vol ū m CBD product, a series of third party testing is conducted throughout the creation process. All Vol ū m product are all-natural, ethical, safe, and completely lab tested. In addition, our Vol ū m products are never animal tested.

For a comprehensive detailing of our lab test results, you can find Volūm HEADACHE Target Roller product detailed here: Heal Test Results


Organic Hemp-Derived Cannabidiol Isolate, Copaiba, Frankincense, Peppermint and Lavender.

How to Use

How to Use Rollers : Massage a small amount directly onto areas where soothing is needed throughout the day. Suggested to use on templates or the back of the neck. Store in a cool place or at room temperature.



Stop using the product immediately and consult a dermatologist when redness, swelling, or other skin irritations occur.

Avoid applying the product on open wounds or skin inflammation. Keep away from direct sunlight and out of reach of infants and children.

200 MG CBD



May help against aging


These statements have not been evaluated
by the Food and Drug Administration.
This product is not intended to diagnose,
treat, cure or prevent any disease.

3rd Party Lab Tested

Why a Roll-On?

This roll-on in your cart offers one of the most efficient and convenient ways to deliver CBD quickly. There is no need to smoke it, eat it, or swallow the CBD content. It goes straight into your skin, the largest organ in your system. While food goes through a long process of delivering the goods, a roll-on bypasses all the stops and is on the job immediately.

CBD is deposited on the skin, seeps in through the layers of the skin, and is deposited where it’s needed. It is not hard on your throat, digestion, or nose because it is delivered directly on target.

This product also contains other medicinal ingredients:

  • Peppermint essential oil has been appreciated for centuries for its ability to melt away pain. It also invigorates, stimulates the brain, and smells delightful.
  • Copaiba oil comes from the Copaiba tree. The resin-like oil is a natural pain-killer, anti-inflammatory agent, and is a promoter of healing. It contains organic infection-fighting ingredients as well.
  • Lavender is a soothing, calming and relaxing essential oil that is known to relieve stress. It clears the mind and instills an overall good vibe, promoting mental health and well-being.

You can actually work this lovely product on grounded areas such as your neck or around your wrist. Doing so will allow it to work on problematic targeted issues like a headache, sinus attack, tennis elbow, or any other complaint you are experiencing.

Why use the Volūm Roll-On?

If you don’t want to smoke or ingest hemp, this method of delivering through your skin is quick and very effective. It is convenient because you can easily take it with you wherever you go and can use it anywhere to relieve painful joints and muscles, eliminate stress, rid yourself of skin irritations, and a ton of other uses.

Big Benefits of CBD

When applying a topical solution of CBD, your body soaks up the benefits of CBD oil very fast. Unlike the process of digesting food where nutrients have to go through the system to break down, the ingredients sink in directly with just a swipe. It’s possible for CBD to instantly provide pain relief.

When you place this product in your cart, you can rest assured you’ll experience fast pain relief.

Although pain relief is an amazing feature of the product, there are other benefits. Using a CBD roll on for pain is priceless.

Adding our CBD roll-on stick in your cart can help ensure your stress and pain will melt away along with the pain.

What We Promise

When you place our roll-on CBD in your cart, you are opting for excellence. We guarantee the CBD we use is of the best high-quality CBD available. We only sell 100% organic CBD, so you never have to worry about toxins, fertilizers, GMOs, or petroleum products tainting the CBD formulation.

Our CBD content is 200 MG per product stick. With that kind of excellence, you’ll see results in mere days, if not hours.

To ensure the maximum beneficial results, we consult the experts for our formulation. We also consult those who know about the growing of hemp, so we derive our roll-on from the best plants in existence.

Whether you have painful discomfort of your joints, stress, or any other mental or physical ailment, we invite you to try this product. Ditch the toxin-ridden, chemical-laden, contaminated products and take what nature has gifted you.

We stand behind all of our products and never sell anything we wouldn’t use on ourselves and on our own family members. Our roll-on CBD is nothing short of astounding with every glorious application. When you choose Volum, you are choosing the best.

Create Wishlist

This take-everywhere roll-on applies clear, absorbs quickly and delivers pinpointed, targeted relief. Roll it anywhere—over temples, fingers, knees or toes—for on the spot and lasting results. Quick tip: Roll it up the back of the neck before bed for a better night’s sleep.

How to use

Roll directly over desired area. Avoid contact with eyes.



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is cbd oil safe for sleep

Best CBD for Sleep—What You Need to Know

Getting a good night’s sleep is essential to your overall health and well-being. Sleep experts recommend that adults sleep seven to nine hours each night. Proper sleep can help ensure that you feel well-rested and have energy for your day ahead. A good night’s rest can help with memory formation and assist with the growth and repair of muscle tissue. Unfortunately, staying and or falling asleep can be difficult, and one increasingly popular strategy is taking CBD for sleep .

Getting a good night’s sleep is essential to your overall health and well-being. Sleep experts recommend that adults sleep seven to nine hours each night. Proper sleep can help ensure that you feel well-rested and have energy for your day ahead. A good night’s rest can help with memory formation and assist with the growth and repair of muscle tissue. Unfortunately, staying and or falling asleep can be difficult, and one increasingly popular strategy is taking CBD for sleep .

As many as 70% of Americans 2 report not sleeping the recommended amount of hours, and nearly one-third of American workers sleep less than six hours per night 3 . So what’s the snooze?

Cannabidiol (CBD) is a derivative of cannabis, with research suggesting that CBD for sleep is helpful and potentially therapeutic. CBD for sleep is commonly used to improve sleep in numerous avenues and potentially decrease anxiety. However, the regulation of CBD in the United States is limited – much more research must be done to determine the exact effects of CBD for sleep and other physical and mental health concerns.

Cannabis and Cannabinoids

While there may be different terms for the green, narrow-leafed plant you often see, the plant is scientifically called Cannabis Sativa L. The word “cannabis” can be utilized to describe products made from the plant. The Cannabis plants contain multiple chemical components including a group commonly referred to as “cannabinoids.” Out of more than 100+ cannabinoids, researchers have primarily studied two that appear to have the greatest impact on humans: tetrahydrocannabinol (THC) and cannabidiol (CBD) .

What is Cannabidiol (CBD)?

CBD is a non-psychoactive cannabinoid, derived from the cannabis Sativa plant, also known as the hemp or marijuana plant. As a naturally occurring compound used in oils, salves, and tinctures, it aims to provide a feeling of relaxation and calmness. Unlike tetrahydrocannabinol (THC), this compound won’t get users “high”.

CBD oil can be extracted from both marijuana and hemp plants. When CBD is derived from the hemp plant, there may be 0.0% – 0.3% THC present. However, CBD oil derived from the marijuana plant may have 0.3% THC or greater present.

CBD for sleep has become of increasing interest for poor sleepers, not to mention the potential benefits of improved sleep quality, latency, and duration of sleep.

Nanocraft CBD creates each and every one of their products with superior genetic hemp strains. All of the hemp used by Nanocraft CBD is grown in nutrient-rich soil right here in the United States. Their farmers operate under strict guidelines and use only 100% organic practices. Not only does their state-of-the-art processing enhance the quality of their high quality genetic strains, but it also ensures that their products are safe, regulated and unsurpassed in their potency and consistency.

What is Tetrahydrocannabinol (THC)?

THC is the medical short-term for tetrahydrocannabinol. THC is the psychoactive compound derived from the cannabis plant. It is responsible for most of marijuana’s physiological effects. When most people think of THC they think of “weed” or “Mary J”.

THC is very different from CBD, in that it connects directly with cannabinoid receptors, thus, giving a “high” effect to users. THC attaches to these receptors activating them and affecting a user’s pleasure, movements, memory, thinking, and concentration.

THC may produce mind-altering effects in users, so if you’re wanting a “high-less” effect, CBD with 0.0% – 0.3% THC would be your best choice. THC stimulates cells in the brain to release dopamine, creating that “feel good” euphoria effect that users rave about.

However, THC may have potential side effects in users that CBD users aren’t really looking for. One of the most important steps Nanocraft takes in great detail is the process to remove even the most minute traces of THC.

Nanocraft uses proprietary technology to remove unwanted compounds still present in the oil. These compounds include wax, chlorophyll, plant pigments and trace amounts of THC. It is then “washed” and “polished” to create the highest quality, zero THC, broad spectrum CBD oil which still contains a robust profile of minor cannabinoids.

What Forms Does CBD Come In?

CBD for sleep can come in different forms, including:

  • Oils and tinctures
  • Vapes
  • Oral sprays
  • Pills and capsules
  • Topical solutions
  • Edible items

Nanocraft has become well-known for their wide array of CBD products available, from CBD Drops , CBD Softgels, CBD Topicals, CBD Powders, and CBD Gummies.

They test every production run for quality and potency. This ensures that all of the cannabinoids, terpenes, essential fatty acids, and phytonutrients are consistent and pure.

Every batch goes through rigorous testing at one of the nation’s leading laboratories. When the batch passes, it receives a Certificate of Analysis and a Certificate of Quality Assurance that they make readily available to our customers. And here’s the great news for you: to date, not one batch has failed to meet their unprecedented testing standards!

What does all of this mean for you? You can use less of Nanocraft’s product to achieve the same level of benefit as the products sold by most of their competitors. We think that’s a reason to celebrate.

What are Common Doses of CBD?

Research has suggested that 300-mg oral doses of CBD for sleep may be taken safely on a daily basis for up to six months. One scientific review demonstrated that taking up to 1,500 mg daily was well-tolerated by participants 4 . A subsequent review confirmed that use of 1,500 mg daily for four weeks 5 displayed no negative effects.

Unfortunately, the indicated CBD for sleep content on a product label may not necessarily be the exact amount that the product actually contains, which may lead people to take more or less CBD than intended. A 2017 analysis published in JAMA analyzed 84 CBD products sold online and showed that 26% of the products contained less CBD than what the label indicated 6 . The same analysis demonstrated that nearly 43% of the products were underlabled; the products contained substantially more CBD than the label said 6 .

While CBD for sleep at higher doses does not appear to have serious negative consequences or adverse effects, these products may also contain levels of THC higher than what is reported on the label. Furthermore, other CBD products for sleep may contain THC that is not reported on the label at all. The THC in these products may produce intoxicating effects, which may or may not be desired by those wanting a better sleep.

What are the Effects of Taking CBD?

Research shows that CBD for sleep may have a calming effect on the nervous system, aiding in sleep and anxiety 7 . CBD for sleep may also alter an individual’s mood because it affects the serotonin system, which helps signal our brain and body that it is time to head to bed. Outcomes from taking CBD for sleep may vary from person to person and can heavily depend on the product type and dosage used.

Unlike THC, CBD does not induce a feeling of being “high” or euphoria in users. Even large doses of CBD do not produce THC-like effects, since CBD is a non-intoxicating compound. In addition, studies of short-term CBD usage have suggested that patients do not experience withdrawal 8 .

How Can CBD Help With Sleep Disorders?

Research on the effects of CBD for sleep is still preliminary and primarily anecdotal. Some individuals who use CBD for sleep and or chronic pain have reported sleeping better. Currently, however, it is not clear as to whether or not these individuals sleep better because of the pain relief or because CBD for sleep directly affects their sleeping pattern, duration, and sleep onset.

Other initial studies of CBD for sleep and sleep disorders suggest positive outcomes 7 . However, not everyone experiences the same sleep benefits with CBD for sleep – different doses may lead to different effects. Research suggests that low doses of CBD for sleep may be stimulating, while high doses of CBD for sleep may exert feelings of sedation 7 . Discrepancies in experiences with CBD for sleep may be attributed to the specific method of CBD administration (i.e. edibles, drops, topicals, etc.) and dosage (i.e. 25 mg, 300 mg, 1,500 mg). Additional research is warranted to further develop and deepen our understanding of CBD for sleep, as an intervention for better sleep and sleep disorders.

What Research Says on CBD for Sleep

Many individuals use CBD for sleep and for other sleep complications and or disorders. According to the Mayo Clinic, sleep troubles may be ignited by a number of factors, including mental anxiety and physical pain 9 . CBD for sleep may show promise and therapeutic potential in managing and assisting with pain and anxiety.

For Pain

Several studies have suggested that CBD for sleep and pain could be helpful. For instance, a 2018 review assessed numerous studies on CBD and pain, concluding that CBD for sleep and pain shows potential as a manageable option 10 .

For Stress

CBD for sleep may also be able to help with anxiety, although more studies are needed to provide insight on the potential therapeutic effects. Previous studies have indicated that CBD for sleep may be able to help individuals in stressful situations 11,12 . CBD may be able to help reduce one’s overall stress levels. So if stress may be keeping you up at night, CBD for sleep may be your best holistic option for a better night’s rest.

Nanocraft Night Time CBD Oil for Sleep

Nanocraft CBD for sleep brings the dream escape you’ve been desiring to your actual dream reality. With a taste of relaxing lavender, a blend of passionflower, a touch of melatonin, and a dream of cannabinol (CBN), a cannabinoid that may help with falling asleep, this calming blend is the perfect way to prepare your mind and body for deep, restorative sleep.

Their Night Time CBD Oil for Sleep formula includes the potential therapeutic benefits from a unique blend of CBN and melatonin, providing you a natural and non-psychoactive effect, preparing your mind and body for a good night’s sleep.

What We Like About Nanocraft Night Time CBD Oil for Sleep:

Try as you might, but you won’t find a better organic formula out there. This Southern California-based company was established in 2017 by two longtime friends Todd Erwin and Stefan McKellar.

They built the brand on a simple mission: create exceptional CBD products that contribute to overall health and wellbeing while also giving back. Their commitment to quality products is as important as their commitment to the causes we support through their program Nanocraft Kids.

Nanocraft aims to be an industry leader by bringing their top-quality hemp derived cannabidiol (CBD) products to the sports, health, and fitness marketplaces. They are also very dedicated to educating consumers on the tremendous health benefits of hemp derived CBD, especially CBD for sleep. Based in sunny La Jolla, California, Nanocraft’s products are formulated to be highly bioavailable to the body, enabling individuals to receive benefits in CBD’s most concentrated form. Zero wasted nutrients and dramatically better absorption. In short, faster, better, more concentrated results.

All of Nanocraft’s products are manufactured in a state-of-the-art cGMP certified laboratory under the critical eye of its Chief Scientific Officer, a chemist and plant biologist who has devoted the past 20 years to nutrition technology. All of their hemp derived CBD is non-GMO, contains no pesticides, solvents, herbicides, or chemical fertilizers. All of their products are always tested by third-party laboratories to ensure quality and consistency. When buying from Nanocraft CBD you can rest assured that their products are completely safe and legal for consumption.

Nanocraft makes broad-spectrum CBD, so you’re getting the synergy from active ingredients in hemp. The cannabinoids, terpenes, and flavonoids allow the body to process CBD more efficiently so that lower doses can remain effective.

The CBD extract is suspended in MCT oil for higher bioavailability. Unlike competitor brands, Nanocraft doesn’t use artificial flavorings and sweeteners in its flavored CBD oils. If you use 40 mg CBD or less (daily), Nanocraft’s products are very affordable in the long run, especially when you consider the quality of their ingredients. Even more so, if you’re using CBD for sleep, for the long haul.

How Much CBD Should I Take to Help with Sleep?

Dosing CBD for sleep is a tricky act because low and high doses of this may produce different effects for different individuals.

For instance, low doses of CBD for sleep tend to potentially promote alertness, while larger doses tend to potentially be more sedative .

However, this dose will vary a lot from one individual to another. The best way to find the best dose for you personally is to do your own trial and error tactic — remain patient until you find a dose that works for you and for your sleep schedule.

The process is sweet and simple:

  1. Start with a low dose (lower than you think you need) – most people start with 1 or 2 mg equivalents of CBD or a ½ of a dropper of CBD oil
  2. Each day, increase the dose by 1-2 mg until you begin feeling the effects
  3. Continue to play around with your dose in small increments until you find one that works reliably and consistently for you

The more you use CBD for sleep, the better you’ll be able to understand how it affects you directly, mind and body. If you experience any side effects, simply try lowering the dose to your previous dosage, where there were no experienced side effects. Or, try taking CBD for sleep along with some food for future doses.

A Final Note on Using CBD Oil for Sleep

CBD for sleep is showing wonderful potential in the world of sleep concerns and disorders. This non-intoxicating, non-psychoactive cannabis compound may be able to help individuals who are experiencing pain, difficulty, or issues with sleep duration, falling asleep, staying asleep, and much more. Although research backing CBD for sleep is still in its early stages, one cannot deny that there is anecdotal and preliminary evidence to support therapeutic effects in humans.

Best CBD for Sleep Apnea – February 2022

Currently, there are no studies on the effects of cannabidiol ( CBD ) on sleep apnea . However, research has shown that CBD might be promising in the treatment of sleep apnea symptoms and the complications that could arise from this medical condition .

CBD for Anxiety and Depression

According to a 2019 study, the frequency of anxiety and depression was higher in patients with obstructive sleep apnea ( OSA ) syndrome than in most people (6) .

The study published in The Permanente Journal revealed that CBD had a calming effect on the central nervous system . Seventy-two adults who had anxiety and sleep problems reported improved sleep and reduced anxiety (7) .

A 2019 study published in the journal Frontiers in Psychology stated that CBD might help reverse anxiety-like behaviors. In the study, 37 patients who had social anxiety disorder reported that their anxiety significantly decreased upon the administration of 300mg of CBD oil (8) .

Research reviewing animal studies has shown that CBD had anxiolytic (anxiety-reducing) and antidepressant properties (9) . Hence, it is suggested that CBD might be helpful in the treatment of disorders related to anxiety and depression.

CBD for Sleep

Sleep apnea patients may have trouble sleeping (insomnia) or experience excessive daytime sleepiness (10) .

A 2017 study published in the journal Current Psychiatry Reports suggested that CBD might have different effects on sleep quality depending on the CBD dose. High doses of CBD had a sedating effect, while low CBD doses were stimulating (11) .

In a study, patients with insomnia who were administered a high dose of 160mg of CBD reported an increase in total sleep time (12) .

A study published in the Journal of Clinical Psychopharmacology found that low doses of CBD were associated with increased wakefulness. Four males and four females who received 15mg of CBD reported alertness (13) .

A case study published in The Permanente Journal has shown that CBD oil administration might have improved the quantity and quality of the test subject’s sleep. The patient also reported a decrease in her anxiety (14) .

Another study published in the Journal of Psychopharmacology found that rodents who were administered with CBD exhibited increased total sleep time (15) .

Loud snoring is a typical symptom of sleep apnea (16) .

Currently, there is no research demonstrating how CBD directly affects snoring. However, there are studies on CBD ’s potential effects on the conditions that contribute to snoring.

According to research published in The American Review of Respiratory Disease , heavy snorers snore more during slow-wave and rapid eye movement (REM) sleep (17) .

A study published in the journal FEBS Letters reported that CBD might reduce REM sleep . The research, which was done on rodents, also found that CBD might increase wakefulness (18) . However, no clear line can be drawn between CBD, snoring, and sleep apnea.

CBD for Headaches and Pain

According to the American Migraine Foundation, sleep apnea patients experience headaches related to the condition. They are typically awakened by these headaches resulting in the patients feeling unrested even after a full night’s sleep (19) .

Headaches are characterized by mild to moderate pain , typically in the neck or back of the head (20) .

A 2020 study published in the journal Frontiers in Pharmacology suggested that CBD might also be a promising treatment for chronic pain relief in several conditions (21) .

A 2018 study published in Transplantation Proceedings was done on seven kidney transplant patients (22) .

The test subjects were initially given 100mg of CBD twice a day for three weeks. The dosage was gradually increased to 150mg during the study’s duration.

Two patients reported total pain improvement, while four had a partial response in the first 15 days. Meanwhile, there was no change in one patient.

The researchers concluded that CBD administration had no severe side effects and was generally well-tolerated by the test subjects.

A study in 2020, published in the journal Current Pharmaceutical Biotechnology , stated that topically applied CBD oil might provide symptomatic relief of peripheral neuropathy of the lower extremities (23) .

The study was conducted in 29 peripheral neuropathy patients. They reported that topical CBD oil administration reduced intense pain, cold and itchy sensations, and sharp pain.

Peripheral neuropathy refers to conditions involving damages to the peripheral nervous system . This system in the body is responsible for sending signals between the brain and the spinal cord to the other parts of the body (24) .

CBD for Hypertension

A 2016 study published in the journal Current Opinion in Pulmonary Medicine revealed that sleep apnea patients are prone to developing hypertension or high blood pressure (25) .

A 2017 study that was published in the journal JCI Insight has shown that a single dose of CBD might reduce blood pressure in healthy test subjects (26) .

Nine healthy males were given a single dose of 600mg of CBD . The test subjects reported reduced blood pressure . The researchers suggested that CBD might have a role in treating cardiovascular disorders. It has yet to be studied in sleep apnea patients with high blood pressure.

In 2017, researchers reviewed 25 research studies examining CBD ’s effects on the dynamics of blood flow. The researchers suggested that CBD might be helpful in treating several cardiovascular disorders, including hypertension, stroke, and myocardial infarction (27) .

CBD for Diabetes

A 2016 study stated that obstructive sleep apnea might be associated with type 2 diabetes (28) .

Type 2 diabetes is a condition that occurs when an individual’s blood sugar (blood glucose) is too high and the body cannot keep up with it. It is the most common diabetes type (29) .

A study that was published in the Journal of the American College of Cardiology noted CBD’s promising effects on diabetes. The study outlined CBD ’s antioxidant, neuroprotective, and anti-inflammatory properties (30) .

The study, which was conducted on rodents, also suggested that CBD might have therapeutic benefits on cardiovascular disorders.

A 2016 study that was published in the journal Diabetes Care has found that CBD combined with tetrahydrocannabivarin (THCV), another cannabis compound, might help reduce blood glucose levels and increase insulin production in type 2 diabetes patients (31) .

Like CBD , THCV comes from the Cannabis sativa plant (32) . Both compounds are nonpsychoactive, which means they do not get users high.

Extensive research has been conducted on CBD and tetrahydrocannabinol ( THC ), which are the primary components of the cannabis plant . However, unlike CBD and THCV, THC may cause a high in users (33) .

How CBD Oil Works to Alleviate Symptoms of Sleep Apnea

A study published in the journal Current Neuropharmacology stated that CBD might potentially modulate an individual’s sleep- wake cycle (34) .

According to the National Sleep Foundation, the sleep- wake cycle , also known as the circadian rhythm or the body clock, is the body’s internal system responsible for regulating feelings of sleepiness and wakefulness over 24 hours (35) .

According to a study published in the journal Sleep, the circadian system has an essential role in the prolongation of sleep apnea (36) . The researchers also suggested that targeting the circadian system might help in the treatment of sleep apnea .

A 2016 study published in the journal Endocrine Reviews stated that the circadian system impacts the body’s sleep- wake cycle . The study also added that the circadian phase at which sleep occurs affects sleep duration, sleep architecture, and continuity (37) .

One of the brain’s regions that responds to light controls the circadian rhythm. This responsiveness to light is why human beings are more alert during the daytime and are prepared to sleep during nighttime (38) .

Research has found that the endocannabinoid system (ECS) helps regulate the circadian rhythm sleep- wake cycle . The researchers suggested that the lack of healthy sleep resulted in dysregulation within the ECS (39) .

The study also noted that the ECS becomes involved in the recovery of sleep after a person experiences abnormal sleep patterns.

The ECS is responsible for regulating body functions, such as mood, pain perception, memory, and appetite. To assist the ECS in regulating these functions, compounds , called cannabinoids , activate the cannabinoid receptors of the ECS (40) .

The primary cannabinoid receptors are known as cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).

CBD and THC are the cannabinoids that have been researched most extensively (41) .

The Pros and Cons of CBD Oil for Sleep Apnea

The Pros
  • Clinical trials , human studies, and research on animals have shown CBD ’s potential benefits for symptoms of obstructive sleep apnea and other sleep apnea types, but is not an established treatment.
  • CBD has an excellent safety profile (42) . Hence, CBD is generally safe to use.
  • The World Health Organization reports that there are no recorded cases of humans developing a physical dependence on CBD (43) . Hence, sleep apnea patients need not worry about developing CBD addiction.
  • As long as state laws permit CBD use, prescriptions are not required when purchasing CBD products .
The Cons
  • Research on CBD and sleep apnea is limited to CBD ’s effects on symptoms and complications related to the sleep condition.
  • CBD still has side effects , such as diarrhea, changes in weight or appetite, and tiredness (44) .
  • The United States Food and Drug Administration (US FDA ) has not approved CBD use in treating medical conditions other than epilepsy. Thus, there is no standard dosage for treating sleep apnea with CBD .
  • CBD products lack regulation. Hence, incidents involving mislabeled CBD products are rampant (45) . Researchers tested 84 CBD products that were bought online. They have found that of the 84 samples, 26% contained less CBD than labeled. 43% contained more CBD than what the label declared, while 21% had THC amounts that were high enough to intoxicate children.

How CBD Oil Compares to Alternative Treatments for Sleep Apnea

The most conventional treatment for sleep apnea is a mask known as a continuous positive airway pressure device ( CPAP ). It fits on the nose or the mouth and keeps an individual’s airway open by gently blowing into this airway as the patient sleeps (46) .

The use of a CPAP is an effective and proven treatment for sleep apnea and its serious complications .

Surgery is another treatment option prescribed to patients. However, the most common surgical procedures, particularly obstructive sleep apnea , do not have a high success rate (47) .

Doctors may recommend that patients implement specific lifestyle changes. Patients may be asked to do the following (48) :

  • Lose weight
  • Exercise
  • Avoid alcohol and medications that relax the back of the throat (they may interfere with breathing)
  • Sleep on one’s side or abdomen instead of on the back
  • Avoid smoking

Doctors do not typically prescribe medications as primary treatment for sleep apnea . However, particular drugs may alleviate some symptoms of sleep disorder , including daytime sleepiness or insomnia (49) .

Conventional medications prescribed for sleep apnea either promote wakefulness, such as modafinil (Provigil) and armodafinil (Nuvigil).

Other drugs act as a sleep aid , like lorazepam (Ativan), diazepam (Valium), and secobarbital sodium (Seconal Sodium).

However, these medications may have side effects . Wakefulness-promoting drugs may cause upper respiratory tract infection, insomnia, anxiety, nausea, nervousness, and headaches (50) .

Meanwhile, barbiturates and other sedatives may cause drowsiness, stomach upset, grogginess, dizziness, mood or behavior changes, and headaches.

Because of these medications’ side effects , people have started seeking out natural remedies (51) .

According to the American Sleep Apnea Association, the dietary supplement melatonin is recommended as an alternative to sleep aids (52) .

Secreted by the pineal gland during nighttime, melatonin is a hormone that causes sleepiness . Its organic origins have made this dietary supplement a go-to choice for Americans (53) .

Melatonin is known for being a sleep aid . However, there is minimal research on melatonin’s effects on sleep apnea .

Research has suggested that melatonin might increase sleep consolidation in untreated obstructive sleep apnea patients (54) .

Another study conducted on animal models revealed that melatonin might prevent hyperglycemia (high blood sugar) (55) .

CBD has a favorable safety profile (56) . Hence, sleep apnea patients may use the hemp extract as a treatment in conjunction with CPAP machine use and the practice of lifestyle changes.

However, patients are discouraged from using CBD with melatonin as there might be possible drug interactions between the two. Melatonin is metabolized by the protein system cytochrome P450 (57) .

CBD may inhibit these proteins (58) . This inhibition may result in reduced melatonin efficacy.

How to Choose the Right CBD for Sleep Apnea

Sleep apnea patients may choose from three types of CBD oils . These options include full-spectrum CBD oil , broad-spectrum CBD oil , and CBD isolates.

More experienced CBD users prefer the full-spectrum type. It uses all the ingredients of the Cannabis sativa plant, such as THC , flavonoids, terpenes, fatty acids, and essential oils.

It is suggested that these active ingredients work synergistically to generate the maximum therapeutic benefits from the plant. This mechanism is popularly known to the CBD community as the entourage effect.

The drawback of using full-spectrum oils is that its THC content, though limited to trace amounts only, may still be detected by some drug tests.

The THC -free version of a full-spectrum oil is called the broad-spectrum oil. It has all the ingredients of a full-spectrum CBD product except for THC .

Patients seeking pure CBD may purchase CBD isolates, as they are made from isolated cannabidiol .

Before purchasing CBD products , one should first ensure that their state laws allow CBD use.

Individuals should also look for high-quality CBD products , which are non-genetically modified organisms and certified organic hemp-derived.

One should also check the legitimacy of a CBD brand. Reading up on reviews and checking if the store is allowed by the government to sell CBD help potential buyers assess a brand’s credibility.

The steps mentioned should be taken, especially if the CBD brand only sells its products online.

CBD Dosage for Sleep Apnea

Due to the lack of FDA regulation, CBD has no standard dosage chart. Sleep apnea patients are encouraged to start with a low dose of CBD and gradually increase the dosage when no adverse reactions occur.

It is essential to note that a study in 2017 reported that high doses of CBD might have sedating effects while low doses might be stimulating (59) .

Patients are encouraged to document their reactions to CBD through a journal they can refer to during a consultation with their physician.

Before adding CBD to their treatment, sleep apnea patients should consult with their doctor first. Properly treated sleep apnea by a medical professional is important to prevent long term complications.

How to Take CBD for Sleep Apnea

CBD products have several forms and formulations that may help sleep apnea patients keep awake or get quality sleep. However, some CBD formats may be more optimal for use than others.

CBD vape pens allow CBD to get into the bloodstream through the lungs, not the digestive system. Hence, the effects may be observed instantaneously.

However, vaping may cause lung problems in some individuals (60) .

It may also be challenging to determine the amount of CBD that sleep apnea patients take in each draw.

CBD tinctures may also be taken sublingually (under the tongue) for added efficacy. Patients can use the dropper to apply CBD oil under the tongue for approximately 60 to 90 seconds before swallowing.

The main advantage of using CBD tinctures is that the dosage may be adjusted according to the sleep apnea patient ’s needs.

CBD oil may also be used for headache relief. Patients may rub the oil on their temples to treat morning headaches that are associated with sleep apnea .

Patients may also use CBD oil products by mixing them with their food and drinks if they dislike CBD ‘s grassy taste.

CBD also comes in formats that can be ingested, such as capsules, pills, gel caps, and gummies . The main advantages of CBD in these formats are convenience and consistent dosage.

CBD may also be bought in topical formulations, like creams, lotions, salves, and balms. However, this format may not be as useful as the others because topicals are limited to external applications.

What Is Sleep Apnea?

According to Mayo Clinic, sleep apnea is a sleeping disorder characterized by an individual’s breathing that repeatedly stops and starts (61) .

Sleep apnea may be categorized into three primary types. These include the following:

  • Obstructive sleep apnea ( OSA ) – This sleep disorder is the most common. It occurs when the throat muscles relax.
  • Central sleep apnea – This type of sleep apnea happens when the brain fails to send the correct signals to the muscles responsible for controlling breathing.
  • Complex sleep apnea syndrome – This disorder happens when an individual is diagnosed with OSA and central sleep apnea . It is also called treatment-emergent central sleep apnea .

Sleep apnea is mainly caused by a person’s physical structure or other medical conditions . These causes are (62) :

  • Obesity
  • Large tonsils
  • Heart or kidney failure
  • Neuromuscular disorders (e.g., stroke)
  • Endocrine disorders (e.g., hypothyroidism)
  • Genetic syndromes (e.g., cleft palate and cleft lip)
  • Premature birth

Symptoms of Sleep Apnea

Sleep apnea symptoms include (63) :

  • Snoring (loud or frequent)
  • Silent pauses when breathing
  • Choking or gasping sounds
  • Daytime sleepiness (fatigue)
  • Morning headaches
  • Unrefreshing sleep
  • Waking up to head to the bathroom during the evening (nocturia)
  • Insomnia
  • Difficulty focusing or concentrating
  • Decreased sexual desire
  • Memory loss
  • Irritability

Sleep apnea risk factors include the following:

  • Overweight or obese individuals
  • Individuals with large neck sizes (large necks have more soft tissues that can block one’s airway while sleeping)
  • Middle age individuals
  • Males
  • Hypertensive patients
  • Individuals with a family history of sleep apnea

Sleep apnea patients may have the following complications (64) :

  • Daytime fatigue (including irritability, drowsiness, and difficulty concentrating while doing daily tasks, such as driving)
  • Cardiovascular problems or hypertension
  • Type 2 diabetes
  • Metabolic syndrome (includes hypertension, high cholesterol, and blood sugar levels, and increased waist circumference)
  • Surgery and medication complications
  • Live problems
  • Sleep-deprived partners (due to loud snoring)


Studies have demonstrated CBD ’s potential therapeutic benefits on the symptoms and complications associated with sleep apnea . Patients with the condition may experience a lack of sleep or less than healthy sleep .

CBD may help with sleep. Studies have shown that CBD might be useful in modulating an individual’s sleep cycle .

Sleep apnea patients are prone to developing disorders, such as anxiety and depression . Extensive research has been done demonstrating CBD ’s anxiolytic and antidepressant properties.

R esearch has yet to be done on CBD ‘s correlation with headaches or migraines. However, researchers have found that CBD might help relieve pain.

Studies have also shown that CBD might be useful in treating hypertension and diabetes. These complications may arise in sleep apnea patients . The best way to treat complications is by treating the sleep apnea under the supervision of a licensed professional.

CBD may be used safely as a complementary therapy to some conventional sleep apnea treatments, such as CPAP machine use, and alternative remedies, like lifestyle changes.

However, patients are advised to avoid using CBD with medications that are metabolized by the proteins CYP450 system.

Drug interactions between CBD and these medicines may occur. Before using CBD in treating sleep apnea , patients should first advise their doctor.

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will cbd oil work for neuropathy

What is neuropathy and can cannabis help?

Tingling. Burning. Shooting. Stabbing. If you suffer from neuropathic pain, these unfortunate adjectives are all too familiar.

Neuropathic pain, or neuropathy, is a catch-all term for pain caused by damage to the nervous system. It’s one of the most common forms of chronic pain, affecting one to two per cent of the population and producing feelings of weakness, numbness, tingling and burning.

“Neuropathic pain is something we see a lot in our older patients,” says Natural Care’s Director of Patient Care, Karen Newell, who is also a registered practical nurse. “It’s fairly common in seniors because they are likely to be dealing with one or more of the conditions that cause it.”

What causes neuropathic pain?

Neuropathy has many causes, including:

  • Alcoholism
  • Autoimmune diseases (including diabetes, multiple sclerosis, lupus, rheumatoid arthritis and thyroid disorders)
  • Chemotherapy treatment
  • Exposure to toxins
  • HIV
  • Injuries
  • Shingles
  • Surgery

How long does neuropathic pain last?

Neuropathic pain can come and go over the course of a day, or even come and go over weeks and months. There’s no one set path for the journey through neuropathic pain. For most, it’s a chronic companion, for some, it’s a temporary travelling partner who can be kicked to the curb.

Can cannabis help neuropathic pain?

Anecdotally, several of our patients report that cannabis helps with their neuropathic pain, but so far the evidence is mixed.

A review published in the AMA Journal of Ethics concluded that cannabis is comparably effective to the traditional agents used to treat neuropathic pain. The review looked at studies conducted with vaporized or smoked cannabis flower of low to medium THC concentration (two to nine per cent). Study subjects ranged from HIV patients dealing with neuropathy to healthy volunteers who had been purposefully injected with pain-inducing capsaicin (the ingredient that makes peppers hot).

Another review, which looked at studies conducted with a range of cannabis products – from synthetic cannabinoids, to sprays containing a mix of THC and CBD, to inhaled flower and more found “no high-quality evidence” to support the use of cannabis for neuropathic pain, citing side effects of sleepiness, dizziness and mental problems compared with placebo.

These reviews are interesting because they both draw their conclusions from a mixed bag of studies, often featuring multiple and diverse cannabis products used to treat neuropathy of multiple and diverse origins. Imagine a sommelier saying “wine never pairs with meat” or “wine always pairs with meat” and you can easily understand the problem we face in interpreting these kind of broad reviews.

Determining the right cannabis product for a specific health goal is more complicated than choosing the right wine for dinner: cannabis comes in many different strains, strengths and formats (vaporized, ingested capsules and oils, etc), and every person processes it differently, making it difficult to generate conclusive prescriptions.

Interestingly, smaller studies looking at specific products and dosages tend to generate more promising results:

A 2013 double-blind, placebo-controlled study published in the Journal of Pain found that low-dose cannabis (1.29 per cent THC or less) significantly improved neuropathic pain when compared with medium-dose and placebo cannabis. Most of the subjects in this study had already experienced poor results with conventional neuropathic pain treatments, leading its authors to conclude that “vaporized cannabis, even at low doses, may present an effective option for patients with treatment-resistant neuropathic pain.”

Similarly, a 2010 trial published in the Canadian Medical Association Journal looked at 23 patients who were assigned three different strengths of cannabis to manage post-traumatic and post-surgical neuropathic pain. The conclusion? “A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep and was well tolerated. Further long-term safety and efficacy studies are indicated.”

Cannabis Pharmacy author Michael Backes writes that this study is particularly significant because the best results were observed at the lowest dose, highlighting “the unexpected medical effectiveness of cannabis dosages that are far below those commonly consumed within the medical community.”

Finding the right product and dose for your neuropathic pain

Backes suggests that a variety of cannabis products, from topicals to oils to flower, may help a variety of neuropathy-related symptoms.

Natural Care nurse practitioner Lynn Haslam says she typically starts neuropathic pain patients on a low nighttime dose of a balanced CBD to THC oil. “We really want the pain managed so they can sleep,” she says. “Neuropathic pain typically gets worse at night, electric shock-like. We may not be able to diminish all of these sensations, but if we can restore sleep, which will help decrease pain during the day, that may be a reasonable goal.”

Setting realistic goals and weighing risks versus benefits is important when working with any medication, adds Haslam. “First-line therapy for neuropathic pain can be nortriptyline or amitriptyline,” she says, “and these medications can cause issues with older adults. This is the same with the other medications commonly used – gabapentin or pregabalin. I think cannabis is usually worth trying.”

In the absence of research that conclusively says which dose and product will work for which type of patient, Natural Care takes a conservative, personalized approach.

“Of course, we follow the latest cannabis research with great interest,” says Newell. “The more studies the better. But on a day to day basis, we weigh potential risks and benefits in a highly individual way – what medications is the patient taking? Are they at risk for drug interactions or falls? Have they had good or bad experiences with cannabis already? What is the nature of their pain, and have they tried other treatments? Then we start at the lowest dose possible and see if it helps. For many of our neuropathic pain patients, that’s enough.”

Can an Oromucosal Spray of THC-CBD Reduce Chronic Neuropathic Pain?

Noncancer-related chronic neuropathic pain may be effectively reduced by treatment with a mixture of tetrahydrocannabinol (THC) and cannabidiol (CBD), but additional large clinical trials are needed to assess the true impact of the medication on this condition. These results were published in the journal Pain Medicine.

Nabiximols (Sativex® oromucosal spray, GW Pharmaceuticals/Jazz Pharmaceuticals) — a complex, botanical mixture of THC and CBD with other cannabinoid and noncannabinoid components — is approved in certain countries, not including the United States, as an add-on therapy for people with chronic neuropathic pain who have inadequate relief from opioids and other analgesics. While numerous systematic reviews and meta-analyses have evaluated both cannabis and cannabinoid-related products (including nabiximols) for chronic pain management, no published reports to date have specifically reviewed the role of nabiximols in chronic neuropathic pain.

Researchers therefore conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of nabiximols and placebo treatments for chronic, noncancer neuropathic pain. Inclusion was restricted to double-blind RCTs.

The meta-analysis included 9 RCTs with a total of 1289 patients (633 treated with nabiximols and 656 who received placebo). Included patients had neuropathic pain of various etiologies, including multiple sclerosis or other neurological defects, spinal cord injury, brachial plexus avulsion, postherpetic neuralgia, peripheral neuropathy, radiculopathy, complex regional pain syndrome type II, postherpetic neuralgia, peripheral neuropathy, focal nerve lesion, and diabetes. Seven studies had parallel group designs and 2 were crossover studies.

Mean study duration was 7.2 weeks. The maximum allowed dosage of nabiximols was 12 to 48 sprays per day (mean dosage, 8-10.9 sprays per day). Patients were permitted to continue treatment with any underlying analgesic medication, with treatment and control groups generally well-matched for concurrent medication. Baseline pain severity was moderate in all studies.

Results of a meta-regression showed no correlation of efficacy with either treatment duration (correlation coefficient [r]=−0.04; P =.386; R 2 =10.9%) or maximum daily dosage (r=0.01; P =.659; R 2 =10.9%).

A pooled endpoint for change in pain scores was significantly in favor of nabiximols over placebo; effect size estimate was −0.40 (95% CI, −0.59 to −0.21) in a fixed effect model and −0.44 (95% CI, −0.70 to −0.19) in a random effects model. Statistical heterogeneity was deemed not important (I 2 =39%).

Nabiximols were associated with a small but significant treatment effect across studies. Standardized mean difference was −0.21 (95% CI, −0.32 to-−0.10) in the fixed effect model and −0.26 (95% CI, −0.42 to −0.10) in the random effects model, with moderate statistical heterogeneity (I 2 =43%).

Sensitivity analysis of effect size estimates for change in pain scores favored nabiximols over placebo for indications of MS or other underlying condition, central or peripheral chronic neuropathic pain, treatment duration ≤6 weeks or >6 weeks, and maximum allowed daily dosage of nabiximols.

Study limitations include the short treatment period in some studies and population heterogeneity in terms of the underlying chronic pain condition.

The results of this analysis suggest that therapy with nabiximols oromucosal spray for chronic noncancer neuropathic pain refractory to usual treatments may be associated with a treatment effect, although not yet statistically significant.

“The emergent message is that individualized RCTs should generally be larger and adequately powered to show a statistically significant effect,” they concluded. “At present, additional larger RCTs specifically designed to assess the effect of nabiximols in neuropathic pain are required” in order to enable more definitive conclusions to be reached.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors’ disclosures.

Using Cannabidiol to Treat Diabetic Peripheral Neuropathy of the Feet

Subjects will be enrolled in the study for a maximum of 43 days, including an optional 14-day screening period, 28 days of active product administration, and followed by a post-treatment follow-up within 1 day.

The primary objective of this study is:

  • To evaluate the safety of PG-DN-20WS for the treatment of painful DPN of the feet compared to a placebo control, including emergence of suicidal thoughts.

The secondary objectives of this study are:

  • To evaluate the impact of PG-DN-20WS on subject’s neuropathic pain, anxiety, and sleep quality compared to a placebo control.
  • To evaluate the impact of PG-DN-20WS on the subject’s impression of their response to the treatment compared to a placebo control.

Layout table for study information

Study Type : Interventional (Clinical Trial)
Estimated Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: There are 2 groups in this trial: interventional group (active drug) and control group (placebo).
Masking: Double (Participant, Investigator)
Masking Description: Subjects will be randomized at a 1:1 ratio.
Primary Purpose: Treatment
Official Title: A Randomized, Double-Blind, Placebo-Controlled Trial Using Cannabidiol for the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet
Actual Study Start Date : December 10, 2020
Estimated Primary Completion Date : March 1, 2021
Estimated Study Completion Date : April 1, 2021
    Incidence of treatment-related adverse events as assessed by CTCAE v4.0 [ Time Frame: Four Weeks ]
    Pain as assessed by Numerical Pain Rating Scale (NPRS) [ Time Frame: Four Weeks ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information

Ages Eligible for Study: 21 Years and older (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
  1. Subject is at least 21 years of age;
  2. Subject has a diagnosis of diabetic neuropathic pain of the feet determined by the subject’s primary care physician or related health care provider.
  3. Subject has a mean pain scale score of ≥ 5 recorded in the 7 days prior to randomization.
  4. If female, the subject is postmenopausal (> 1 year), surgically sterile (> 3 months), had a hysterectomy, or is currently using 2 effective forms of birth control.
  5. Subject has not taken marijuana (cannabis) in any form, chemicals or extracts or foods or beverages or topical creams, lotions, gels, patches containing marijuana (cannabinoids, or and cannabis derivatives) including synthetic marijuana and/or CBD for at least 14 days prior to this study, and agrees to not take marijuana (cannabis) in any form, chemicals or extracts or foods or beverages or topical creams, lotions, gels, patches containing marijuana (cannabinoids, or and cannabis derivatives) including synthetic marijuana and/or CBD while participating in this study.
  6. If subject is currently taking gabapentin, pregabalin, or duloxetine, subject must be willing to and completes a 7-day washout of these medications prior to randomization.
  7. Subject has not taken any NSAIDs and/or acetaminophen for at least 2 days prior to randomization.
  8. Subject is willing to provide his/her written informed consent to participate in the study as stated in the informed consent document.
  9. Subject is willing to use an electronic diary to enter trial information for 29 days.
  1. Subject is pregnant or lactating;
  2. Subject has an allergy to cannabis, the Cannabaceae plant family (e.g., hemp, hops), palmitoylethanolamide, or terpenes;
  3. Subject has a known allergy to active or inert ingredients of the investigational product;
  4. Subject is taking a concomitant medication or treatment that would complicate use or interpretation of the study drug’s effects (examples include: Cannabis or any cannabinoid products; Any drug or herbal product that influences the endocannabinoid system (ECS));
  5. Subject is taking marijuana (cannabis) in any form, chemicals or extracts or foods or beverages or topical creams, lotions, gels, patches containing marijuana (cannabinoids, or and cannabis derivatives) including synthetic marijuana and/or CBD for at least 14 days prior to this study, and does not promise that they will not take marijuana (cannabis) in any form, chemicals or extracts or foods or beverages or topical creams, lotions, gels, patches containing marijuana (cannabinoids, or and cannabis derivatives) including synthetic marijuana and/or CBD while participating in this study;
  6. Subject currently resides in the state of Nebraska, Idaho, Iowa, or South Dakota.
  7. Subject is currently being treated with antibiotics for sinus, throat, or lung infections;
  8. Subject has shortness of breath associated with allergies;
  9. Subject has uncontrolled asthma;
  10. Subject has a fever and/or productive cough;
  11. Subject has unstable angina, uncontrolled hypertension;
  12. Subject currently or has a history of congestive heart failure;
  13. Subject has any other unstable medical condition;
  14. Subject has a personal or family history of schizophrenia;
  15. Subject has a personal history or currently has suicidal ideation or attempted suicide;
  16. Subject has a major neurological disorder, such as dementia, Parkinson’s disease, cognitive impairment, epilepsy, history of traumatic brain injury/head injury, and seizures.
  17. Subject has taken pharmaceutical pain medicine of any kind, or has taken a NSAID and/or acetaminophen, within 2 days of randomization.
  18. Subject has taken gabapentin, pregabalin, or duloxetine within 7 days prior to randomization or is unwilling to stop these medications.
  19. Subject has an allergy to, or has an intolerance to, NSAIDs or acetaminophen.
  20. Subject is currently taking any form of opioids.
  21. Subject has a history of substance or alcohol abuse.
  22. Subject has clinically significant illness, including cardiovascular disorders.
  23. Subject has any condition in which the investigator believes will confound the data of the study or could put the subject at risk of harm.
  24. Subject does not have access to a smart phone or does not know how to use a smart phone application.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

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will cbd oil cause a positive test for cannabinoids

CBD: What Is It and Will It Result in a Positive Drug Test for Marijuana?

Cannabidiol, also known as CBD, is a natural substance that has recently gained popularity due to its use as a remedy to treat certain physical ailments.

CBD is a naturally occurring compound found in cannabis plants, the marijuana plant, or hemp plant. Hemp derived oil (CBD) has been a legal import in the United States for decades.

In theory, CBD oil should consist of two main ingredients: the compound cannabidiol dissolved in an oil made from hemp seeds or coconut.

Will using CBD oil result in a positive drug test for marijuana? The short answer is that it should not, but in reality, it could.

According to Dr. Barry Sample, Director of Science and Technology with Quest Diagnostics, CBD, itself, on a drug test would not be confused with either marijuana (THC) or marijuana metabolite (THC metabolite) and analytically the two substances can be clearly differentiated.

However, someone using a CBD oil that contains residual THC could very likely test positive on a urine drug test, not because of the CBD itself, but because of THC contaminants in the oil. Additionally, if a CBD product contains THC at a sufficiently high concentration (0.3% or greater), it possibly can cause a positive drug test result for marijuana metabolites.

THC is still considered a Schedule I controlled substance by the Drug Enforcement Agency (DEA) pursuant to the 1970 Controlled Substances Act.

What Is CBD Oil and Will It Cause a Positive Drug Test?

One of the most common things that people are concerned about when it comes to taking CBD oil is whether or not it will show up on a drug test.

No one likes being made to take a drug test, but the whole thing is a lot more terrifying if you have recently taken CBD oil and don’t know what will happen to you.

So, will CBD oil cause a positive drug test?

What Is CBD Oil?

Before you can find out if CBD oil will cause a positive result on a drug test, you first need to understand what CBD oil is.

CBD oil contains cannabidiol, one of the main cannabinoids found in cannabis plants. Unlike its better-known cousin THC, CBD is entirely non-intoxicating and doesn’t cause any kind of high.

However, CBD is still able to affect a myriad of different bodily functions. For example, studies have shown CBD oil to be an effective way to help treat conditions like arthritis thanks to its anti-inflammatory properties.

The problem of drug tests, however, comes from the endocannabinoid system. The ECS is the same system that is affected by both CBD and THC, just in different ways.

So why does this make some people fear a positive result on a drug test?

How CBD Oil Could Affect a Drug Test

The primary reason that CBD oil could potentially cause problems regarding drug tests is due to the way the drug tests are calibrated.

There is no central agency or organization behind the commercial drug tests that many companies use, resulting in a variety of different testing criteria.

This means that different testing organizations test for different things and at wildly different rates. Depending on what type of test a company uses, they might test for any and all cannabinoids, potentially triggering CBD as a false positive.

There is also the chance that some THC within your CBD oil might cause a problem.

How the THC within Some CBD Oils Can Cause Problems

While many CBD oils only contain CBD and nothing else, there are plenty that contain other cannabinoids as well. Known as full spectrum CBD oils, this type of CBD oil includes small amounts of other cannabinoids, including THC.

While the quantity of THC within most full spectrum CBD oils is typically monumentally small, it is still possible for it to register on certain drug tests. Different countries and states have different levels of allowable THC in their CBD oil, but individual testing centers might set their own limits.

CBD oil can thus register positive on a drug test if the CBD comes from full spectrum CBD oil.

The solution to this is to buy CBD isolates or broad-spectrum oils. CBD isolates contain only CBD and no other cannabinoids, whereas broad-spectrum CBD oils contain other cannabinoids alongside CBD, but never any THC.

Final Thoughts: Will CBD Cause a Positive Drug Test?

The idea of being accused of breaking company policy or somehow getting in trouble by taking CBD oil is a pretty scary one. With the myriad testing parameters, great care needs to be taken when buying CBD oils.

When looking to buy CBD oil , try to shop at stores that offer CBD isolate options for best results. Places like Premium Jane offer all kinds of different CBD products, some of which are isolates or broad spectrum.

While it might be a bit tricky to find only products that don’t contain THC, search for either “isolate” or “broad spectrum” to find CBD oils that won’t cause any problems on drug tests whatsoever.

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what is the demand for cbd oil online

Cannabidiol (CBD) Market Trends 2021 | North America, Europe, & APAC Industry Forecasts 2027: Graphical Research

Prominent CBD manufacturers across the globe include Canopy Growth Corporation, Cronos Group, Medterra Tilray, CBD One Ltd, Formula Swiss AG, Green Brothers Switzerland SA, HemPoland sp. z o.o. MH medical hemp GmbH, ECOFIBRE, Bod Australia Ltd, MEDLAB CLINICAL, Aurora Cannabis, and CV Sciences, Inc.

June 02, 2021 06:00 ET | Source: Graphical Research Graphical Research

Pune, India, June 02, 2021 (GLOBE NEWSWIRE) —

The global cannabidiol market size is anticipated to expand at substantial CAGR during the forecast period as CBD is quite famous for treating large number of ailments like anxiety, chronic and neurological pains, sleep disorders, stress, and nausea.

Cannabidiol (CBD) offers a wide variety of therapeutic benefits to the user and is non-toxic in nature as well. Several governments across the world have now made the use of CBD legal in their countries because of its many uses that can help in the creation of new drugs, leading to medical advancements.

Some of the trends that will encourage the growth of global CBD market up to 2027 are listed below:

Cannabidiol oil will witness hike in demand in North America:

North America cannabidiol market is expected to surpass $61.2 billion in size by 2027. Based on product, this market is divided into oil, tinctures, transdermal patches, suppository, tablets, capsules, vape oil, isolates, creams, roll-ons, and many others. Out of these, the CBD oil segment is projected to grow rapidly during the forecast period of 2021-2027.

In fact, this segment dominated the market in 2019 and will continue to do so in the future as well. CBD oil is known to have several benefits for its users, especially for pain-related ailments. Cases of mental illness in North America are increasing every year. Mental health institutions are increasingly demanding CBD oil as it is quite famous for treating various mental illnesses like depression and anxiety, thereby positively influencing the substance demand.

Access sample pages of the report, “North America Cannabidiol (CBD) Market Forecasts 2027” in detail along with the table of contents (ToC) @

Chronic pain patients are the largest consumers of CBD in U.S.:

There are several applications of CBD like anxiety, chronic stress, depression, skin care, seizures, joint pain & inflammations, among others. Out of these, CBD will find increased application in the chronic pain segment through 2027, reaching a valuation of $20.6 billion by 2027 across North America, according to current market trends. CBD has several beneficial properties to relieve chronic pain and is a better alternative when compared to its counterpart, opioids.

CBD gives minimal side-effects from use and does not contain toxic elements. This has resulted in increased demand for CBD-derived medicines and products as a better alternative to conventional medicines, augmenting the market size in the U.S.

Online distribution of CBD to gain prominence in North America:

There are two primary distribution channels established to sell CBD in North America: online and offline channels. The offline distribution channels are further divided into pharmacies and retail stores. The offline distribution channel in the region is set to gain momentum through 2027 and will expand at 32.6% CAGR during this time.

One of the major reasons for this is that offline channels are more reliable as compared to their online counterparts. Customers prefer the offline channels to buy their medicines as it not only increases their confidence in their purchases, but they can personally inspect the product as well before buying it. Another important reason is that it is much easier for store owners to monitor CBD products, something that is not possible with online channels.

Favorable government regulations to foster Asia Pacific cannabidiol market:

CBD market in Asia Pacific is predicted to become worth more than $1.9 billion by 2027, according to market reports. CBD was not on the list of legal products in several countries across the region. But today, that scenario has drastically changed as countries like Japan, Australia and New Zealand have made favorable changes in their laws to make the use of CBD based products legal among their population.

The regulatory bodies of these countries have inspected the benefits of CBD-derived products on human body and have given their approval in this regard. For example, Australian authorities approved the use of a CBD-based product, Sativex in 2017 to treat spasticity caused by multiple sclerosis. This drug has won the approval of more than 28 countries, which is an indication of positive changes in the regulatory framework of these nations. All these factors will positively impact the demand for CBD in Asia Pacific.

Access sample pages of the report, “Asia Pacific Cannabidiol (CBD) Market Forecasts 2027” in detail along with the table of contents (ToC) @

CBD tinctures will witness upsurge in demand in Asia Pacific:

Out of the different CBD-derived products like oils, creams and tinctures, the CBD tincture segment is predicted to gain traction and is expected to grow at an incredible 36% CAGR through 2027 in APAC. This segment had the second-largest regional market share in 2020 with a valuation of more than $18.5 million. One of the main reasons for this is that this product has a longer shelf life as compared to its alternatives. It has a wide range of applications as well like treating anxiety, nausea, inflammation, and pain.

These tinctures are made with CBD strains taken from hemp plant and contain 60% to 70% alcohol content, prompting increased demand for them among end-users.

Creams and roll-ons will experience increased demand in Europe:

Total Europe CBD market is projected to go past $25.8 billion by 2027. Oils, tablets, creams & roll-ons, capsules, vape oil and many other products use CBD oil as the main ingredient. Out of these, the creams & roll-ons segment will witness robust growth during the mentioned timeline as there is a rising emphasis among consumers to use skincare products that contain CBD.

This ingredient is known to have many benefits for the skin and helps in improving its quality as well. A large percentage of the population in Europe is increasing their spending on various cosmetic and skincare products each year. While talking about the medicinal benefits of CBD, it has been proved that this product has anti-inflammatory properties, which is a must-have in all skincare and makeup products. All these will benefit the market companies in Europe.

Access sample pages of the report, “Europe Cannabidiol (CBD) Market Forecasts 2027” in detail along with the table of contents (ToC) @

Prevalence of mental disorders will stimulate Europe CBD consumption:

Anxiety, chronic stress, depression, migraines, skincare, inflammation, and many other areas are using CBD-based products for various purposes. But it is the anxiety & stress segment that will attract the most demand for this product in the coming years. This segment captured 22% of the total Europe market share in 2020 and is expected to grow further in the future.

The population in Europe is experiencing a worrying rise in the number of mental disorders like anxiety & stress, sleep disorders and depression. This has led to an increasing number of healthcare institutions to adopt CBD-based medications to treat these ailments. According to the World Health Organization, nearly 4.3% of the regional population has fallen prey to depression. All these aspects will promote the development of the market.

About Graphical Research:

Graphical Research is a business research firm that provides industry insights, market forecast and strategic inputs through granular research reports and advisory services. We publish targeted research reports with an aim to address varied customer needs, from market penetration and entry strategies to portfolio management and strategic outlook. We understand that business requirements are unique: our syndicate reports are designed to ensure relevance for industry participants across the value chain. We also provide custom reports that are tailored to the exact needs of the customer, with dedicated analyst support across the purchase lifecycle.

Global CBD Oil Market 2020 | Trends, Development Status, Investment Opportunities, CAGR, Revenue, Demand and Forecast to 2024 | Technavio

LONDON–( BUSINESS WIRE )–The CBD oil market is poised to grow by USD 3.52 billion during 2020-2024 progressing at a CAGR of over 32% during the forecast period.

Technavio suggests three forecast scenarios (optimistic, probable, and pessimistic) considering the impact of COVID-19. Download Free Sample Report on COVID-19 Recovery Analysis

The report on the CBD oil market provides a holistic update, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis.

The report offers an up-to-date analysis regarding the current global market scenario, the latest trends and drivers, and the overall market environment. The market is driven by the health benefits of CBD oil.

The CBD oil market analysis includes the product segment and geography landscape. This study identifies the growing legalization of cannabis-based products as one of the prime reasons driving the CBD oil market growth during the next few years.

This report presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters

The CBD Oil Market Covers the following areas:

CBD Oil Market Sizing

CBD Oil Market Forecast

CBD Oil Market Analysis

Companies Mentioned

  • Aurora Cannabis Inc.
  • Canopy Growth Corp.
  • CBD American Shaman LLC
  • CV Sciences Inc.
  • Elixinol Global Ltd.
  • Gaia Botanicals LLC
  • Isodiol International Inc.
  • Medical Marijuana Inc.
  • NuLeaf Naturals LLC.

Key Topics Covered:




  • Market ecosystem
  • Market characteristics
  • Market segmentation analysis


  • Market definition
  • Market sizing 2019
  • Market size and forecast 2019-2024


  • Bargaining power of buyers
  • Bargaining power of suppliers
  • Threat of new entrants
  • Threat of substitutes
  • Threat of rivalry
  • Market condition


  • Market segmentation by product
  • Comparison by product
  • Marijuana-derived CBD oil – Market size and forecast 2019-2024
  • Hemp-derived CBD oil – Market size and forecast 2019-2024
  • Market opportunity by product



  • Geographic segmentation
  • Geographic comparison
  • North America – Market size and forecast 2019-2024
  • South America – Market size and forecast 2019-2024
  • Europe – Market size and forecast 2019-2024
  • APAC – Market size and forecast 2019-2024
  • MEA – Market size and forecast 2019-2024
  • Key leading countries
  • Market opportunity



  • Market drivers
  • Market challenges


  • Growing legalization of cannabis-based products
  • Exponential online retail growth
  • Increasing frequency of mergers and acquisitions


  • Overview
  • Landscape disruption
  • Competitive scenario


  • Vendors covered
  • Vendor classification
  • Market positioning of vendors
  • Aurora Cannabis Inc.
  • Canopy Growth Corp.
  • CBD American Shaman LLC
  • CV Sciences Inc.
  • Elixinol Global Ltd.
  • Gaia Botanicals LLC
  • Isodiol International Inc.
  • Medical Marijuana, Inc.
  • NuLeaf Naturals LLC


  • Research methodology
  • List of abbreviations
  • Definition of market positioning of vendors


About Us

Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio’s report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio’s comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

How To Sell CBD Online: A Guide to Buying, Selling, and Shipping CBD

If you’re interested in entering the fast-growing online CBD resale market, now is the time. By the end of 2020, the U.S. CBD industry is expected to pull in a record $4.7 billion in sales, according to research done by Brightfield Group. By 2025, estimates point to an industry worth $16.8 billion annually. The COVID-19 pandemic pushed 47% of CBD sales online in the second quarter of the year, as brick-and-mortar stores closed, and wary consumers chose to shop from home instead.

With an opportunity like this calling, it’s an exciting time to answer. In this post, we lay out the details of what it takes to buy, sell, and ship CBD online. We also explore the basics of how to sell CBD online, including how to get the right licenses, popular CBD products to sell, what to look for in a wholesaler, and how to explore opportunities with white labeling.

Federal and State Laws

As with any new product, government regulations are in a state of flux. From a federal regulatory standpoint, selling CBD is legal provided that the THC content of your products stays below 0.3%. You don’t currently need a license at the federal level to sell CBD.

Other laws vary from state to state. Some states do not allow the sale of CBD derived from marijuana plants. So to be on the safe side, stick with hemp-produced CBD products. Since each state has a unique set of regulations regarding CBD sales, check your state’s laws before you open up shop to make sure you’re complying.

Business and Reseller Licenses

Your first step is to establish your business as a legal entity in your state. In most cases, this can be done through the Secretary of State’s office. You’ll need to select the type of legal structure to operate your business under. There are a handful of choices, but the two most common are an LLC or S Corp. Some local governments also require a business license. Check if yours does, and if so, be sure to secure one before you get started. Lastly, many states require a reseller license if you’re buying wholesale.

Setting Up an Online Shop

With all of the licensing out of the way, you’re ready to set up an online CBD business. Step one is buying a domain name. GoDaddy is one of the largest domain registrars in the U.S., and their internet domain selector tool makes it easy to see what domain names are available for purchase.

Next comes setting up your e-commerce site. There are a number of vendors to choose from, but BigCommerce and Shopify are two of the most popular. Finally, you’ll need to select a payment processor. Many of the traditional payment processors like PayPal won’t allow CBD payments to be processed on their platforms. However, Shift Processing has a service specially designed for CBD vendors who sell CBD online.

Choosing the right CBD Products to Sell

CBD comes in a wide range of forms: tinctures, edibles, isolates, capsules, topicals, patches, and pet products, just to name a few. Choosing the right CBD products to sell online is important, especially if you’re going to be targeting a specific niche audience. Do some market research to figure out what type of CBD products appeal to the consumers you’ll be selling to.

Finding a Quality CBD Wholesaler

Partnering with a quality CBD wholesaler is essential. Before placing your first order, you’ll want to do some homework.

First, examine the quality of the products. Find out where they source their raw hemp. Is it produced domestically or in some other country? If in another country, what are their safety and quality regulations like? How do they extract the CBD from the hemp? There’s more than one method of extraction, but Co2 extraction results in some of the highest quality finished products. You should also ask to see a copy of the wholesaler’s Certification of Analysis (CoA). A quality producer will hire a third-party testing company to analyze their products and produce a CoA that details the levels of CBD, THC, and other compounds found in the product.

Next, look at the CBD wholesaler’s product offerings and pricing. Do they carry a wide enough range of dosage levels and product choices? Being able to offer a wide range of options to your customers can supercharge your efforts to sell CBD online. What is their pricing structure? Do they have a minimum order? Do they have a reputation for being easy to work with, efficient, and fair? If you’re interested in white labeling, are they set up for that?

Benefits of Selling White Label CBD Products

White labeling gives you an opportunity to take your CBD online business to the next level. With white labeling, you create your own brand and product names, product labels and packaging, and marketing. White labeling can set you apart from other CBD online sellers, offering the potential for higher profits and greater control over the branding.

Options for Shipping Your CBD Products

When it comes to fulfilling orders sold on your CBD online marketplace, you have three main options. First is in-house order fulfillment. That means you’re packaging and shipping the products yourself. While that may work when you’re just starting out, you’re likely to need some help as your online CBD business grows.

The second option is dropshipping. Some CBD wholesalers will package and mail your orders for you directly from their warehouse. And the last method is third-party fulfillment. This is the most expensive option but by far the most convenient. A third-party fulfillment company warehouses, packs, and ships your products for you. Many of these companies offer handy add-on services like handling customer returns and customer service requests.

The Time is Ripe for Selling CBD Online

Now is an exciting time to be entering into the online CBD marketplace. As demand continues to grow and consumers steadily shift their buying habits to online sources, the potential for growth in the CBD industry is tremendous. By investing the time to set up your online CBD business the right way today, you’ll be well-positioned to take advantage of this emerging market for years to come.