Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction The purpose of this study is to assess how Cannabidiol (CBD) impacts the effectiveness of oral contraceptive (birth WebMD provides information about interactions between Next Choice oral and hormonal-contraceptives-cannabidiol-tetrahydrocannabinol.
Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction
The purpose of this study is to assess how Cannabidiol (CBD) impacts the effectiveness of oral contraceptive (birth control) pills and if CBD changes the possible side effects of birth control pills when CBD and birth control pills are taken at the same time.
This study explores the potential interaction between CBD and birth control pills by assessing serum levels of the contraceptive steroid hormones ethinyl estradiol and levonorgestrel in birth control pill users when they also use CBD.
|Condition or disease||Intervention/treatment||Phase|
|Contraception||Drug: Cannabidiol Oil Drug: Placebo Drug: Combined oral contraceptive pill||Phase 4|
Participants will be randomized to either the CBD or placebo for cycle one, followed by a washout cycle. For cycle three, participants will take the opposite of what they received in Cycle one. For example if they received CBD during cycle one they will take placebo for cycle 3.
Hormonal Contraceptives/Cannabidiol; Tetrahydrocannabinol Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Cannabidiol (CBD) and tetrahydrocannabinol (THC) may speed up how quickly your body processes your hormonal contraceptive.
What might happen:
Hormonal contraceptives (e.g. “the pill”, patches, implants, some IUDs, and the ring) may not be effective while you are taking CBD or THC, and you may become pregnant if you do not use other forms of birth control.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You should use a back-up form of birth control (e.g. condoms) or a non-hormonal form of birth control while taking CBD or THC. If you have questions about your birth control, discuss them with your doctor or pharmacist.Emergency contraceptives may be less effective also. You may need a larger dose than normal. Discuss the dose and the need to confirm that you do not become pregnant with a pregnancy test with your healthcare professional.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.