Acid forms of cannabinoids prevent the coronavirus spike protein from binding to human receptor sites. /PRNewswire/ — Hometown Hero CBD is pleased to announce the release of its new CBDA + CBGA Tincture. The 30ml tincture features CBDA, CBGA, CBD, and CBG at… So what’re the differences between CBD, CBDA, CBGA and marijuana plants you’d buy at a dispensary?
Hemp compounds found to fight COVID-19
Acid forms of cannabinoids prevent the coronavirus spike protein from binding to human receptor sites.
New research that is creating quite the buzz found that two compounds commonly found in hemp have the potential to combat the SARS-CoV-2 coronavirus. The compounds, cannabidiolic acid, or CBDA, and cannabigerolic acid, or CBGA, block a critical step in the process the virus uses to infect people.
No, it does not mean you can smoke weed and prevent the ’rona.
No, it does not (necessarily) mean you can squirt some CBD oil from that tincture bottle and keep the ’vid at bay. The CBDA and CBGA are not usually found in commercial hemp CBD products, but some notable companies are out there, such as Ancient Cannabis out of Oregon and Essentia Scientific from Washington state.
“CBDA and CBGG are available commercially,”said Stacy Cason at Planetarie CBDa out of Colorado, “though definitely in the minority and not in your average CBD isolate in oil product.”
“The ‘A’ forms, these are the acid forms of CBD and CBG that are generally not in most commercially available hemp products,” said Lynda LeMole, a natural products industry consultant. “The acid forms are found in the fresh plant. There are processes that stabilize the acid forms so you’d have to look at the product’s test analysis to see if the acid forms are still present in the final product.”
CBDA and CBGA naturally exist in true whole-plant hemp extracts that are not overly distilled to raise CBD content. “The data on whole plant vs CBD isolated follows the basic tenet of true botanical medicine,” said Carl Germano, vice president at Verdant Oasis. “The synergism of the whole plant performs better than isolated components from them.”
The two compounds were identified during a chemical screening by researchers at the Linus Pauling Institute at Oregon State University. The compounds bind to spike proteins found on the virus and blocked the spike protein from binding to sites in a human host, thereby preventing a step the pathogen uses to infect people.
“The acid forms are significantly under-appreciated,” said cannabis consultant Richard Rose. “Even non-stony THCA.”
Heat inactivates the compounds and makes them unable to bind to the spike protein. That is why smoking marijuana would not work.
The researchers used the alpha and beta virus forms of the SARS-CoV-2 virus, not the latter-day delta variant nor today’s omicron variant.
But the researchers are confident these and future variants could be similarly thwarted by CBDA and CBGA.
“Regarding activity against other variants of the virus, we are hopeful that activity against the original strain and two early variants might mean activity against subsequent strains,” lead researcher Richard van Breemen, Ph.D., told Natural Products Insider. Van Breemen is professor of pharmaceutical sciences at the Linus Pauling Institute and College of Pharmacy at the Oregon State University Global Hemp Innovation Center. “That experiment, however, is yet to be done.”
Even so, the research continues the story of various natural products, like vitamin D, zinc and quercetin, that can be used as therapeutic agents against the pandemic. It also demonstrates the burgeoning possibilities into cannabinoid medicine now that the plant is being liberated from the clutches of a near-century lockdown.
“We’re just scratching the surface of what we know about cannabinoid mother and minors in the CBD family, and the positive and effective impacts it may have for preventive and therapeutic care including virus-based maladies as research is indicating,” said Thom Brodeur, CEO of Sky Wellness, a CBD brand. “There is more research to do, more ground to cover and more to discover that may—like this recent research suggests—show us use cases and value for CBD and its derivatives that have been right under our noses all this time. That’s the exciting part.”
Van Breemen concurs that the door is just being opened to hemp research.
“Hemp is a rich source of plant secondary metabolites, many of which are unique and not found in other organisms,” he said. “Already, CBD has been approved by the FDA for the treatment of some juvenile forms of epilepsy. Our findings suggest that other cannabinoids might also have medicinal properties.”
A major remaining roadblock is that coming from FDA, which gives every indication it would prefer cannabinoid medicine to be available to the public strictly through pharmaceutical drug pipelines and not through the more promiscuous dietary supplement route.
Not one week after the Oregon research was disclosed, FDA approved for use in clinical trials a CBD-based treatment for opioid use disorder. Ananda Scientific, the drug’s maker, was granted by FDA an investigational new drug (IND) designation for Nantheia ATL5.
Hometown Hero CBD launches New CBDA + CBGA Tincture Amid COVID-19 Surge
With 600mg of CBDA and 600mg of CBGA, this new hemp-derived product is legal in all 50 states and can be ordered online.
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Jan 19, 2022, 11:00 ET
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AUSTIN, Texas , Jan. 19, 2022 /PRNewswire/ — Hometown Hero CBD is pleased to announce the release of its new CBDA + CBGA Tincture. The 30ml tincture features CBDA, CBGA, CBD, and CBG at 600mg each. All the cannabinoids in tincture are hemp-derived and the product is legal in all 50 states. As with all of Hometown Hero CBD’s products, a portion of proceeds from the CBDA + CBGA Tincture will be donated to nonprofit organizations that help U.S. veterans in need.
“Hometown Hero is honored to provide a product that can help the world get through these difficult times,” said Lukas Gilkey , CEO of Hometown Hero CBD. “When we heard about their promising effects and rarity, we immediately stepped up to make sure that CBDA and CBGA would be accessible to the general public. We believe this product can have a massive positive impact.”
CBDA and CBGA recently came into the spotlight following the publication of research from Oregon State University . The two compounds only appear in greater quantities during the beginning of the plant’s life cycle. They also degrade when exposed to heat and light. Because of these factors, very few products contain substantial amounts of viable CBDA and CBGA in a consumable form.
The new CBDA + CBGA Tincture is vegan, gluten-free, and sugar-free. The tincture can provide a 30 day supply of cannabinoids when consumed at the rate of one full dropper (1ml) per day. In total, the tincture’s contents include:
- 600mg CBDA (cannabidiolic acid)
- 600mg CBGA (cannabigerolic acid)
- 600mg CBD (cannabidiol)
- 600mg CBG (cannabigerol)
- MCT oil from organic coconuts (carrier oil)
Adults 21 and older that are curious to try Hometown Hero CBD’s products can get free samples of its hemp-derived Delta-9 THC and Delta-8 THC gummies.
In the face of the Omicron variant, Hometown Hero CBD remains dedicated to taking extensive precautions to deter COVID-19 exposure in its manufacturing processes. To learn more about Hometown Hero CBD, its full range of products, and its mission of supporting U.S. veterans, visit HometownHeroCBD.com.
About Hometown Hero CBD
Hometown Hero CBD manufactures and distributes hemp-derived Delta-9 THC, Delta-8 THC, and CBD products. Founded in 2015 by U.S. Coast Guard veteran Lukas Gilkey and Lewis Hamer , the company donates a portion of proceeds from all products sold to various charities and organizations that support veterans. For more information, visit HometownHeroCBD.com, email us at [email protected] or follow the brand on Facebook and Twitter at @HometownHeroATX and Instagram at @HometownHeroATX.
Cannabis and COVID: Key differences between CBD, CBDA and CBGA
New study finds cannabis compounds block coronavirus proteins
Ken Haddad , Digital Content Manager
GRANTHAM, ENGLAND – AUGUST 27: Hemp oil is tested for quality in the process department at British CBD oil producer Crop England on August 27, 2021 in Grantham, England. British CBD oil was founded in 2019 by Mike and Jackie Lamyman. The popularity of CBD oil from the cannabis family of plants has grown in recent years due to its health properties. (Chris Furlong, 2021 Getty Images)
A study published this week by researchers at Oregon State University found some hemp compounds have the ability to prevent the virus that causes COVID-19 from entering human cells.
Findings of the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, College of Pharmacy and Linus Pauling Institute, were published this week in the Journal of Natural Products.
Hemp, known scientifically as cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.
“We identified several cannabinoid ligands and ranked them by affinity to the spike protein,” van Breemen said. “The two cannabinoids with the highest affinities for the spike protein were CBDA and CBGA, and they were confirmed to block infection.”
So what’re the differences between CBD, CBDA, CBGA and marijuana plants you’d buy at a dispensary?
CBD, an abbreviation for cannabidiol, doesn’t produce any psychoactive effects. It’s likely what you see at some pharmacies, health stores or dispensaries.
It’s a very versatile compound, which makes it ideal for oils, gummies, lotions, creams and other products. Hemp contains a lot of CBD.
But CBD is not the compound that was tested in the Oregon State study. CBD is activated in hemp plants from its original form — CBDA.
CBDA, known as cannabidiolic acid, is secreted in the stems, leaves and flowers of a cannabis plant. When the plant undergoes activation (a process with heat), the acid is removed from the CBDA, activating CBD.
They have similar compounds, but CBDA is not as versatile. It’s usually extracted by “juicing” plant material, and can be added to foods, drinks, or used in tinctures, concentrated herbal extracts.
But basically, CBDA is the raw form of CBD. And it’s not as easy to find. But you can buy it. (It has not been studied as much as CBD)
CBGA, known as cannabigerolic acid, is considered the “mother cannabinoid,” because without it, there is no CBD, CBDA or THC.
CBGA compounds are similar to other cannabinoids, but it hasn’t been studied nearly as much as the others. It’s non-intoxicating. Enzymes called synthases are responsible for converting the CBGA into molecules such as THCA, the raw, unactivated molecule that converts to THC after heat is applied.
Again, you can find this in oils and tinctures online, but it’s harder to find and at times, pretty expensive, because it’s harder to extract.
What about smoking marijuana?
At this point, it doesn’t appear that just smoking marijuana, even a heavy CBD strain, will produce the effects reported in this study. We don’t have enough information to suggest it.
CBDA or CBGA products, like oils, offering these in their raw form, do not work the same in marijuana products, which usually include high levels of THC, the psychoactive compound that makes you high.
And before trying something new, do your research, talk to your doctor and make sure it’s something you should bring into your life. Check out Project CBD for some information on getting started.
Copyright 2022 by WDIV ClickOnDetroit – All rights reserved.
About the Author:
Ken Haddad is the digital content and audience manager for WDIV / ClickOnDetroit.com. He also authors the Morning Report Newsletter and various other newsletters. He’s been with WDIV since 2013. He enjoys suffering through Lions games on Sundays in the fall.