Cannabis for peripheral neuropathy: The good, the bad, and the unknown Cannabis may be an effective alternative or adjunctive treatment for peripheral neuropathy, an often debilitating condition 23 Best CBD Creams for Neuropathy in Feet Millions of people suffer from peripheral neuropathy, but CBD can help. Learn how to use CBD foot soaks to alleviate debilitating nerve pain in the feet.
Cannabis for peripheral neuropathy: The good, the bad, and the unknown
Cannabis may be an effective alternative or adjunctive treatment for peripheral neuropathy, an often debilitating condition for which standard treatments often provide little relief. Most studies show moderately improved pain from inhaled cannabis use, but adverse effects such as impaired cognition and respiratory problems are common, especially at high doses. Data on the long-term safety of cannabis treatments are limited. Until riskbenefit profiles are better characterized, doctors in states where cannabis therapy is legal should recommend it for peripheral neuropathy only after careful consideration.
Small clinical studies have found that cannabis provides benefits for peripheral neuropathy, including pain reduction, better sleep, and improved function, even in patients with symptoms refractory to standard therapies.
Adverse effects such as throat irritation, headache, and dizziness are common, and serious neuropsychiatric effects can occur at high doses.
Safety may not be adequately assessed in US trials because cannabis supplied by the National Institute of Drug Abuse is less potent than commercially available products.
M arijuana, which is still illegal under federal law but legal in 30 states for medical purposes as of this writing, has shown promising results for treating peripheral neuropathy. Studies suggest that cannabis may be an option for patients whose pain responds poorly to standard treatments; however, its use may be restricted by cognitive and psychiatric adverse effects, particularly at high doses. 1
See related editorial, page 950
In this article, we discuss the basic pharmacology of cannabis and how it may affect neuropathic pain. We review clinical trials on its use for peripheral neuropathy and provide guidance for its use.
PERIPHERAL NEUROPATHY IS COMMON AND COMPLEX
An estimated 20 million people in the United States suffer from neuropathic pain. The prevalence is higher in certain populations, with 26% of people over age 65 and 30% of patients with diabetes mellitus affected. 2–4
Peripheral neuropathy is a complex, chronic state that occurs when nerve fibers are damaged, dysfunctional, or injured, sending incorrect signals to pain centers in the central nervous system. 5 It is characterized by weakness, pain, and paresthesias that typically begin in the hands or feet and progress proximally. 4 Symptoms depend on the number and types of nerves affected.
In many cases, peripheral neuropathy is idiopathic, but common causes include diabetes, alcoholism, human immunodeficiency virus (HIV) infection, and autoimmune disease. Others include toxicity from chemotherapy and heavy metals.
Peripheral neuropathy significantly worsens quality of life and function. Many patients experience emotional, cognitive, and functional problems, resulting in high rates of medical and psychiatric comorbidities and occupational impairment. 4,6,7 Yet despite its clinical and epidemiologic significance, it is often undertreated. 8
STANDARD TREATMENTS INADEQUATE
Peripheral neuropathy occurs in patients with a wide range of comorbidities and is especially difficult to treat. Mainstays of therapy include anticonvulsants, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors. 9 A more invasive option is spinal cord stimulation.
These treatments can have considerable adverse effects, and response rates remain suboptimal, with pain relief insufficient to improve quality of life for many patients. 9,10 Better treatments are needed to improve clinical outcomes and patient experience. 11
CANNABIS: A MIX OF COMPOUNDS
Cannabis sativa has been used as an analgesic for centuries. The plant contains more than 400 chemical compounds and is often used for its euphoric properties. Long-term use may lead to addiction and cognitive impairment. 12,13
Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main components and the 2 best-studied cannabinoids with analgesic effects.
THC is the primary psychoactive component of cannabis. Its effects include relaxation, altered perception, heightened sensations, increased libido, and perceptual distortions of time and space. Temporary effects may include decreased short-term memory, dry mouth, impaired motor function, conjunctival injection, paranoia, and anxiety.
CBD is nonpsychoactive and has anti-inflammatory and antioxidant properties. It has been shown to reduce pain and inflammation without the effects of THC. 14
Other compounds in the cannabis plant include phytocannabinoids, flavonoids, and tapenoids, which may produce individual, interactive, or synergistic effects. 15 Different strains of cannabis have varying amounts of the individual components, making comparisons among clinical studies difficult.
THE ENDOCANNABINOID SYSTEM
The endogenous mammalian cannabinoid system plays a regulatory role in the development, homeostasis, and neuroplasticity of the central nervous system. It is also involved in modulating pain transmission in the nociceptive pathway.
Two of the most abundant cannabinoid endogenous ligands are anandamide and 2-arachidonylglycerol. 9 These endocannabinoids are produced on demand in the central nervous system to reduce pain by acting as a circuit breaker. 16–18 They target the G proteincoupled cannabinoid receptors CB1 and CB2, located throughout the central and peripheral nervous system and in organs and tissues. 12
CB1 receptors are found primarily in the central nervous system, specifically in areas involved in movement, such as the basal ganglia and cerebellum, as well as in areas involved in memory, such as the hippocampus. 12 They are also abundant in brain regions implicated in conducting and modulating pain signals, including the periaqueductal gray and the dorsal horn of the spinal cord. 16–20
CB2 receptors are mostly found in peripheral tissues and organs, mainly those involved in the immune system, including splenic, tonsillar, and hematopoietic cells. 12 They help regulate inflammation, allodynia, and hyperalgesia. 17
Modifying response to injury
Following a nerve injury, neurons along the nociceptive pathway may become more reactive and responsive in a process known as sensitization. 21 The process involves a cascade of cellular events that result in sprouting of painsensitive nerve endings. 21,22
Cannabinoids are thought to reduce pain by modifying these cellular events. They also inhibit nociceptive conduction in the dorsal horn of the spinal cord and in the ascending spinothalamic tract. 20 CB1 receptors found in nociceptive terminals along the peripheral nervous system impede pain conduction, while activation of CB2 receptors in immune cells decreases the release of nociceptive agents.
STUDIES OF CANNABIS FOR NEUROPATHIC PAIN
A number of studies have evaluated cannabis for treating neuropathic pain. Overall, available data support the efficacy of smoked or inhaled cannabis in its flower form when used as monotherapy or adjunctive therapy for relief of neuropathic pain of various etiologies. Many studies also report secondary benefits, including better sleep and functional improvement. 23,24
However, adverse effects are common, especially at high doses, and include difficulty concentrating, lightheadedness, fatigue, and tachycardia. More serious reported adverse effects include anxiety, paranoia, and psychosis.
Wilsey et al, 2008: Neuropathic pain reduced
Wilsey et al 25 conducted a double-blind, placebo-controlled crossover study that assessed the effects of smoking cannabis in 38 patients with central or peripheral neuropathic pain. Participants were assigned to smoke either high- or low-dose cannabis (7% or 3.5% delta-9-THC) or placebo cigarettes. Cigarettes were smoked during treatment sessions using the following regimen: 2 puffs at 60 minutes from baseline, 3 puffs at 120 minutes, and 4 puffs at 180 minutes. Patients were assessed after each set of puffs and for 2 hours afterwards. The primary outcome was spontaneous relief of pain as measured by a visual analog scale.
Pain intensity was comparable and significantly reduced in both treatment groups compared with placebo. At the high dose, some participants experienced neurocognitive impairment in attention, learning, memory, and psychomotor speed; only learning and memory declined at the low dose.
Ellis et al, 2009: Pain reduction in HIV neuropathy
Ellis et al 23 conducted a double-blind, placebo-controlled crossover trial in patients with HIV neuropathy that was unresponsive to at least 2 analgesics with different modes of action. During each treatment week, participants were randomly assigned to smoke either active cannabis or placebo, while continuing their standard therapy. Titration started at 4% THC and was adjusted based on tolerability and efficacy. Twenty-eight of the 34 enrolled patients completed both cannabis and placebo treatments. The principal outcome was change in pain intensity from baseline at the end of each week, using the Descriptor Differential Scale of Pain Intensity.
Of the 28 patients, 46% achieved an average pain reduction of 3.3 points (30%). One patient experienced cannabis-induced psychosis, and another developed an intractable cough, which resolved with smoking cessation.
Ware et al, 2010: Reduced posttraumatic or postsurgical neuropathic pain
Ware et al 24 performed a randomized crossover trial in 21 patients with posttraumatic or postsurgical neuropathic pain. Participants inhaled 4 different formulations of cannabis (containing 0%, 2.5%, 6.0%, and 9.4% THC) during 4 14-day periods. They inhaled a 25-mg dose through a pipe 3 times a day for the first 5 days of each cycle, followed by a 9-day washout period. Daily average pain intensity was measured using a numeric rating scale. The investigators also assessed mood, sleep, quality of life, and adverse effects.
Patients in the 9.4% THC group reported significantly less pain and better sleep, with average pain scores decreasing from 6.1 to 5.4 on an 11-point scale. Although the benefit was modest, the authors noted that the pain had been refractory to standard treatments.
The number of reported adverse events increased with greater potency and were most commonly throat irritation, burning sensation, headache, dizziness, and fatigue. This study suggests that THC potency affects tolerability, with higher doses eliciting clinically important adverse effects, some of which may reduce the ability to perform activities of daily living, such as driving.
Wilsey et al, 2013: Use in resistant neuropathic pain
Wilsey et al 26 conducted another double-blind, placebo-controlled crossover study assessing the effect of vaporized cannabis on central and peripheral neuropathic pain resistant to first-line pharmacotherapies. Dose-effect relationships were explored using medium-dose (3.5%), low-dose (1.3%), and placebo cannabis. The primary outcome measure was a 30% reduction in pain intensity based on a visual analog scale.
In the placebo group, 26% of patients achieved this vs 57% of the low-dose cannabis group and 61% of those receiving the medium dose. No significant difference was found between the 2 active doses in reducing neuropathic pain, and both were more effective than placebo. The number needed to treat to achieve a 30% reduction in pain was about 3 for both cannabis groups compared with placebo. Psychoactive effects were minimal, of short duration, and reversible.
Wallace et al, 2015: Use in diabetic peripheral neuropathy
Wallace et al 27 conducted a randomized, double-blind, placebo-controlled crossover study evaluating cannabis for diabetic peripheral neuropathy in 16 patients. Each had experienced at least 6 months of neuropathic pain in their feet. The participants inhaled a single dose of 1%, 4%, or 7% THC cannabis or placebo. Spontaneous pain was reported with a visual analog scale and also tested with a foam brush and von Frey filament at intervals until 4 hours after treatment.
Pain scores were lower with treatment compared with placebo, with high-dose cannabis having the greatest analgesic effect. Pain reduction lasted for the full duration of the test. Cannabis recipients had declines in attention and working memory, with the high-dose group experiencing the greatest impact 15 minutes after treatment. High-dose recipients also had poorer scores on testing of quick task-switching, with the greatest effect at 2 hours. 27
Research and market cannabis are not equal
Results of US studies must be qualified. Most have used cannabis provided by the National Institute of Drug Abuse (NIDA), 23–26 which differs in potency from commercially available preparations. This limits the clinical usefulness of the analysis of benefits and risks.
Vergara et al 28 found that NIDA varieties contained much lower THC levels and as much as 23 times the cannabinol content as cannabis in state-legalized markets.
Studies based on NIDA varieties likely underestimate the risks of consumer-purchased cannabis, as THC is believed to be most responsible for the risk of psychosis and impaired driving and cognition. 24,28
CBD MAY PROTECT AGAINST ADVERSE EFFECTS
Studies of CBD alone are limited to preclinical data. 29 Evidence suggests that CBD alone or combined with THC can suppress chronic neuropathic pain, and that CBD may have a protective effect after nerve injury. 30
Nabiximols, an oromucosal spray preparation with equal amounts of THC and CBD, has been approved in Canada as well as in European countries including the United Kingdom. Although its use has not been associated with many of the adverse effects of inhaled cannabis, 30–32 evidence of efficacy from clinical trials has been mixed.
Lynch et al, 31 in a 2014 randomized, double-blind, placebo-controlled crossover pilot study 31 evaluated nabiximols in 16 patients with neuropathic pain related to chemotherapy. No statistically significant difference was found between treatment and placebo. However, the trial was underpowered.
Serpell et al, 32 in a 2014 European randomized, placebo-controlled parallel-group study, evaluated 246 patients with peripheral neuropathy with allodynia, with 128 receiving active treatment (THC-CBD oromucosal spray) and 118 receiving placebo. Over the 15-week study, participants continued their current analgesic treatments.
Pain was reduced in the treatment group, but the difference from placebo was not statistically significant. However, the treatment group reported significantly better sleep quality and Patient Global Impression of Change measures (reflecting a patient’s belief of treatment efficacy).
META-ANALYSES CONFIRM EFFECT
Three meta-analyses of available studies of the effects of cannabis on neuropathic pain have been completed.
Andreae et al, 2015: 5 trials, 178 patients
Andreae et al 1 evaluated 5 randomized controlled trials in 178 patients in North America. All had had neuropathy for at least 3 months, with a pain level of at least about 3 on a scale of 10. Two studies had patients with HIV-related neuropathy; the other 3 involved patients with neuropathy related to trauma, diabetes, complex regional pain syndrome, or spinal cord injury. All trials used whole cannabis plant provided by NIDA, and the main outcomes were patient-reported pain scales. No study evaluated pain beyond 2 weeks after trial termination.
They found that 1 of every 5 to 6 patients treated with cannabis had at least a 30% pain reduction.
Nugent et al, 2017: 13 trials, 246 patients
Nugent et al 33 reviewed 13 trials in 246 patients that evaluated the effects of different cannabis-based preparations on either central or peripheral neuropathic pain from various conditions. Actively treated patients were more likely to report a 30% improvement in neuropathic pain. Again, studies tended to be small and brief.
Cochrane review, 2018: 16 trials, 1,750 patients
A Cochrane review 34 analyzed 16 trials (in 1,750 patients) lasting 2 to 26 weeks. Treatments included an oromucosal spray with a plant-derived combination of THC and CBD, nabilone, inhaled herbal cannabis, and plantderived THC.
With cannabis-based treatments, significantly more people achieved 50% or greater pain relief than with placebo (21% vs 17%, number needed to treat 20); 30% pain reduction was achieved in 39% of treated patients vs 33% of patients taking placebo (number needed to treat 11).
On the other hand, significantly more participants withdrew from studies because of adverse events with cannabis-based treatments than placebo (10% vs 5%), with psychiatric disorders occurring in 17% of patients receiving active treatment vs 5% of those receiving placebo (number needed to harm 10).
The primary studies suffered from methodologic limitations including small size, short duration, and inconsistency of formulations and study designs. Further evaluation of longterm efficacy, tolerability, and addiction potential is critical to determine the risk-benefit ratio.
RISKS OF CANNABIS USE
Like any drug therapy, cannabis has effects that may limit its use. Cannabis can affect a person’s psyche, physiology, and lifestyle.
Impaired attention, task speed
Neurocognitive changes associated with cannabis use—especially dizziness, fatigue, and slowed task-switching—could affect driving and other complex tasks. Evidence indicates that such activities should be avoided in the hours after treatment. 26,27,32,33
Concern over brain development
Most worrisome is the effect of long-term cannabis use on brain development in young adults. Regular use of cannabis at an early age is associated with lower IQ, decline in school performance, and lower rates of high school graduation. 35
Avoid in psychiatric patients
It is unlikely that cannabis can be safely used in patients with psychiatric illnesses. Anxiety, depression, and psychotic disorders can be exacerbated by the regular use of cannabis, and the risk of developing these conditions is increased while using cannabis. 36,37
THC potency affects tolerability
High concentrations of THC (the highest concentration used in the above studies was 9.5%) can cause anxiety, paranoia, and psychosis.
Long-term cannabis smoking may cause wheezing, cough, dyspnea, and exacerbations of chronic bronchitis. There is some evidence that symptoms improve after stopping smoking. 33,38
SHOULD WE RECOMMEND CANNABIS?
Where cannabis can be legally used, doctors should be familiar with the literature and its limitations so that they can counsel patients on the best use and potential risks and benefits of cannabis treatment.
A recent conceptualization of pain suggests that a pain score reflects a composite of sensory factors (eg, tissue damage), cognitive factors (eg, beliefs about pain), and affective factors (eg, anxiety, depression). 39 Physicians should keep this in mind when evaluating patients to better assess the risks and benefits of cannabis. While pharmacotherapy may address sensory factors, cognitive behavioral therapy may help alter beliefs about the pain as well as anxiety and depressive symptoms that might influence subjective reports.
Ideally, patients being considered for cannabis treatment would have a type of neuropathic pain proven to respond to cannabis in randomized, controlled studies, as well as evidence of failed first-line treatments.
Relative contraindications include depression, anxiety, substance use, psychotic disorders, and respiratory conditions, and these should also be considered.
Although current research shows an analgesic benefit of cannabis on neuropathic pain comparable to that of gabapentin, 40 further investigation is needed to better evaluate long-term safety, efficacy, and interactions with standard therapies. Until we have a more complete picture, we should use the current literature, along with a thorough knowledge of each patient, to determine if the benefits of cannabis therapy outweigh the risks.
We thank Camillo Ferrari, BS, and Christina McMahon, BA, for their helpful comments.
23 Best CBD Creams for Neuropathy in Feet
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There are an estimated 2.5 million people in the USA who suffer from neuropathy, a condition where nerves all over the body become inflamed and damaged, causing pain and numbness. This can happen due to diabetes or other medical conditions or for no reason at all (idiopathic). Today we’re going to discuss the best CBD creams for neuropathy in feet.
What is CBD oil cream?
CBD oil cream is a natural product made from CBD oil. It’s often used to treat skin conditions like eczema and arthritis, but it can also be used for neuropathic pain relief. The non-psychoactive compound of the cannabis plant, CBD oil offers many benefits for people with various symptoms and serious medical conditions.
How does CBD oil cream work?
CBD works by reducing inflammation and blocking the pain signals that are sent to your brain. The endocannabinoid system (ECS) is a big part of this process as it helps cells stay in homeostasis. Every time you use cannabis, whether it’s from smoking or from a hemp product like CBD oil, your ECS reminds cells to function properly. CBD is said to help regulate over 5 major systems:
· The digestive system
· The nervous system
· The immune system
The endocannabinoid system controls many of your body’s major functions, and it is very important that we keep this system working at its best. This will help to regulate sleep, appetite, immune function as well as pain and sensory perception such as smell and sight.
What symptoms does CBD oil cream treat?
CBD is effective at treating symptoms both big and small. It’s been proven to be beneficial for people struggling with arthritis, chronic pain, and more serious conditions like cancer and multiple sclerosis. It can be used for a variety of skin conditions as well. In the case of neuropathy in feet, CBD cream delivers targeted relief to inflamed nerve endings and calms itchy skin.
How do I know if my neuropathy in feet will respond to CBD oil cream?
Many people find that CBD helps relieve pain from all types of neuropathy, but some conditions respond better than others. The first step is to talk to your doctor about CBD oil cream. If they feel that you could benefit from it, they will recommend a product and help you determine if your specific condition can be treated with CBD.
How do I use CBD cream on my feet?
CBD cream on the feet should be applied two to three times a day. Apply a generous amount of cream and massage into the affected area. Most CBD companies recommend that you start with a pea sized amount and work your way up from there, depending on the severity of your condition.
How does CBD oil cream benefit people with neuropathy in feet?
People who suffer from neuropathy in feet often experience severe pain and discomfort in their feet. They may feel like they’re walking on pins and needles or that it feels like they’re being stung by bees. CBD oil cream works to block the pain signals sent from these damaged nerves so that you feel less discomfort. Many people who have experienced relief from CBD oil cream say it’s a lifesaver for them and have even tried other medications, which didn’t work as well, before trying this natural alternative.
What is CBD cream made of?
CBD oil cream is made from CBD oil, coconut oil, shea butter, cocoa butter, hemp seed oil and essential oils. It’s important to note that not every cannabis company uses the same blend for their CBD creams. Some offer a more potent product, while others offer a lighter formula. Always make sure to check the milligrams of CBD in each serving before using CBD oil cream.
What are the benefits of CBD creams?
CBD lotions give you all the health advantages of cannabis-based products in general, and CBD in particular, without any psychoactive effects. This makes it a great option for people who want the benefits of cannabis but don’t like the high or side effects (which can include euphoria and/or dizziness) associated with marijuana products.
Are there any side effects of CBD oil cream?
As with any new medication, it’s important to check with your doctor first before using CBD oil cream or any other cannabis product. It’s also vital to know that not everyone responds the same way to CBD products so it is best to use trial and error to determine if this treatment works for you. There are some people who may experience an upset stomach, dry mouth or drowsiness when using CBD products.
Is hemp oil the same as CBD oil?
CBD oil comes from the plant, hemp. Hemp is part of the same family as marijuana but it’s not the same. CBD oil will not get you high and there are no psychoactive properties associated with it. This product is made from the flowers, leaves and stalks of hemp plants and contains less than .3 percent THC, which is the compound that causes users to feel high.
Hemp oil is often used for cooking and has a variety of benefits. It contains omega-3 fatty acids, which are beneficial for improving heart health. It also increases glutathione production in the body, which helps boost your immune system so you can fight off different kinds of diseases more easily.
CBD oil is also made from hemp and has many of the same benefits. It’s often referred to as CBD-rich hemp oil, CBD-hemp tincture or just plain old hemp extract. If you’re looking for a cannabis product that won’t get you high but still offers all of the health benefits of marijuana, this is your best option.
How Do I choose the right CBD oil cream?
Of course, the first thing you need to do when choosing a cannabis-based product is learning how much CBD or THC it contains. These two elements are only available in marijuana plants and both interact with your endocannabinoid system (ECS) through different pathways, which means that they can produce quite different effects.
Only products which have been tested by a third party should be considered, and the label should always indicate the exact amount of CBD or THC per dose. In addition to these two main factors, there are several other things you need to take into account when choosing a CBD cream for neuropathy in feet.
Type and concentration of terpenes.
Terpenes are essential oils that give cannabis strains their distinctive flavors, aromas and effects. Some terpenes have very specific properties for medical use. The best CBD creams will include a full spectrum of cannabinoids and terpenes to maximize benefits.
How much CBD is in the product? This is important to know before buying or consuming any cannabis-based product. Some people might need a simple topical cream while others will want something stronger like transdermal patches, capsules or vape pens.
A brand that has positive reviews and high ratings from customers should be your first choice.
And last but not least, CBD oils should be manufactured using extraction methods that don’t involve toxic solvents like propane and butane. These harsh chemicals can harm your health when they’re heated up.
1. Penguin CBD Cream
Image courtesy Penguin CBD
This topical CBD cream is designed to work no matter how you choose to use it.
Not only can you apply it directly to the painful areas of your feet, but you can also take it before bed so that the ingredients have time to absorb into your skin overnight. This means fewer side effects and more benefits from its moisturizing properties.
2. Everest CBD Full-Spectrum
Image courtesy Everest
The high grade of Everest’s full-spectrum CBD oil makes it perfect for your needs. They use naturally grown hemp, which means they have more natural ingredients and aren’t deprived like other brands. This is by far, one of the more excellent options of CBD creams for neuropathy in feet on this list.
3. R+R Medicinals
Image courtesy R+R Medicinals
This cream is designed to be used by individuals who want fast results. It uses all-natural ingredients like olive oil, beeswax, and CBD to give you the ultimate level of pain relief without any irritation or harmful side effects.
4. Verma Farms CBD Cream
Image courtesy Verma Farms
This is an all-natural topical cream that can be applied to any part of your body. It uses organic ingredients, including THC-free CBD so you know you will have a safe and pleasant experience with it. Plus, Verma Farms has made this product affordable so everyone can enjoy its benefits without having to spend too much money.
5. Leaf Remedys Cooling Gel
Image courtesy Leaf Remedys
This cooling gel is made with 100% all-natural ingredients that feature CBD. It also includes hempseed oil, willow bark extract, and other organic elements to give you the ultimate comfort without any irritation or harmful side effects to your skin.
6. Batch CBD
Image courtesy Batch CBD
This cream is made from 100% natural hemp oil that uses CBD to naturally relieve your pain. It works on any part of your body without causing irritation or uncomfortable side effects. Plus, it’s made with many organic ingredients that are safe for you and the environment.
7. Colorado Botanicals
Image courtesy Colorado Botanicals
Looking for an all-natural way to help with your chronic pain? Well look no further! This CBD oil is perfect if you’re just starting out or have naturally low tolerances and won’t give yourself too many side effects. Colorado Botanicals’ high-quality CBD oil is mixed with natural, organic MCT Oil (from coconut) which has a variety of health benefits.
8. FOCL Relief Cream
Image courtesy FOCL
This CBD cream is designed to be used on all different areas of your body. It works to quickly reduce pain, soothe irritation, and relax muscles so you can feel comfortable again. It goes on nice and smooth without any greasiness or sticky residues that other creams leave behind.
9. CBDfx Muscle and Joint Cream
Image courtesy CBDfx
If you’re looking for a CBD cream that will reduce your pain quickly, this is the one. It’s specifically designed to give quick relief from any sort of muscular or joint discomfort by using fast-acting ingredients like menthol and camphor.
10. Medterra Pain Relief Cream
Image courtesy Medterra
This cream is designed to use CBD and arnica to ease your muscles and make them feel great again. It also uses avocado oil, Shea butter, and many other organic ingredients to give you the ultimate level of comfort without any side effects.
11. CBDfx Foot Care Set
Image courtesy CBDfx
This foot cream caters to individuals who are suffering from feet pain due to diabetes. It’s made with CBD oil and Vitamin E, which work together to promote healing while soothing any sort of discomfort you might be feeling. The peppermint scent works like aromatherapy for an extra boost of relaxation while also making it easier for the product to absorb into your skin.
12. CBDMedic Aches and Pain Relief
Image courtesy CBDmedic
This topical pain relief cream contains 10 mg of CBD isolate, which is the purest form of CBD available. It uses all-natural ingredients to keep skin healthy and nourished while reducing inflammation and sensitivity. This means no side effects like dryness or itchiness because it’s designed with your comfort in mind.
13. Vertly Lotion
Image courtesy Vertly
This product is made from 100% natural hemp oil that features over 1400 mg of CBD, terpenes, and other beneficial cannabinoids. The powerful combination of these ingredients helps promote the production of endorphins, which are your body’s natural painkillers.
14. Harmonious CBD Pain Salve
Image courtesy Harmonious CBD
This topical CBD cream is eco-friendly, vegan, and made from 100% all-natural ingredients. It’s also free of parabens and any other harmful chemicals like petroleum and formaldehyde. This means it won’t irritate your skin while still targeting the pain you’re feeling.
15. CBDistillery Oils
Image courtesy CBDistillery
If you’re looking for a product that will ease your pain with the most benefits, this is the one. It features up to 1000 mg of CBD, which is more than many other brands use in their products. This makes it perfect for individuals who need help with inflammation, anxiety, depression, and neuropathy in feet.
16. Pure Hemp Isolate Cream
Image courtesy Pure Hemp
This product is high-quality and tasty. It uses 100% pure hemp oil that has been extracted from the plant using natural methods for a healthy alternative to pain relief. Plus, it’s made without any extra ingredients or preservatives, making it safe for your skin.
17. BioTech CBD Oil Roll On
Image courtesy BioTech
This CBD oil contains 100% natural ingredients that work to reduce inflammation. It’s also made without any chemicals or preservatives that could do more harm than good for your skin. You can use it on any part of your body without worrying about the effects.
18. NuLeaf Naturals CBD Salve
Image courtesy NuLeaf Naturals
This salve is made with organic hemp oil that has been infused with essential oils for a soothing effect. It’s all-natural and doesn’t contain any chemicals or artificial ingredients that could irritate your skin. It comes in three different strengths for you to choose from depending on what you need relief from.
19. CBD.Co CBD Foot Care Bundle
Image courtesy CBD.co
This bundle is the perfect product for individuals who are looking to take control of their pain. The CBD oil works with your body to promote healthy feet while relieving any discomfort you might be feeling. Also, it includes a foot scrub and blanket so you can feel even more comfortable.
20. Aspen Green Muscle Relief Cream
Image courtesy Aspen Green
This muscle relief cream is made from 100% organic ingredients, which means you can trust it won’t irritate your skin or make you feel uncomfortable. Plus, it uses 2000 mg of CBD to help naturally manage the pain and soreness in your feet.
21. Level Select 2 CBD Sports Cream
Image courtesy Level Select 2
This cream is designed to be used by athletes who are tired of having their muscles ache after a workout. It uses an all-natural blend of ingredients that work together to relieve soreness and make your body feel good again.
22. Lord Jones CBD Body Oil
Image courtesy Lord Jones
Made from pure Icelandic water and all-natural ingredients, this CBD oil targets pain as effectively as pharmaceuticals but without the extra chemicals. The essential oils like lavender and bergamot nourish your skin and leave you feeling relaxed after a long day of work.
23. cbdMD Cream
Image courtesy cbdMD
cbdMD’s broad-spectrum hemp extract provides relief from minor ailments while histamine dihydrochloride creates an enjoyable warming sensation to soothe your muscles overnight! Add in aloe vera with MSM as well as essential oils like arnica or oregano just waiting out there ready when you need them most – this cream has got everything needed at all times to soothe neuropathy in feet.
Is there a cure for neuropathy in the feet?
There are many different causes associated with neuropathy and many of these can be treated or cured.
Neuropathic pain is classified by the International Association for the Study of Pain as one of the most common types of chronic pain.
The treatment for neuropathy can be done in two ways- pharmacological management and non-pharmacological management. The doctors prescribe medications that work to manage neuropathy in the feet. This may include gabapentin, carbamazepine, or other antiepileptics.
The non-pharmacological management includes physiotherapy sessions where the doctors use ultrasound therapy, diathermy, and electrical nerve stimulation (TENS) among others to help relieve the discomfort in your feet. The patients are also advised to take measures like exercising, changing their lifestyle and diet habits.
There is no cure for neuropathy in the feet, but it can be managed with painkillers like ibuprofen or aspirin. There are creams available that claim to provide relief from the discomfort of neuropathy in the feet; they may contain ingredients like menthol or camphor. You can also opt for CBD oil and cream and get relief from this condition.
Can you put CBD oil on your feet?
Yes, you can apply CBD oil on your feet to give them a healthy glow or help relieve neuropathy. The oil is made of natural ingredients that will not cause any harm to the skin. It is safe for daily use and does not cause any irritation or crusting of the skin.
There are specific creams available in the market that contain CBD extracts for giving a healthy glow to the skin and relieving nerve pain on your feet. CBD oil is a good healer and can provide relief from pain, inflammation, and stiffness of joints. It also helps in smoothing scars left by injuries or accidents.
What is the maximum strength CBD cream?
Maximum strength CBD cream is the one that contains 20% of CBD oil in it. The rest of the ingredients comprise of natural products like beeswax, shea butter, coconut oil, and vitamin E.
This cream helps with faster absorption in your skin so that you can get quick relief from daily discomfort. Since maximum strength CBD creams contain higher amounts of CBD, they are slightly costlier than other products containing lower amounts.
The maximum strength creams give you immense relief from muscle pain, neuropathy in feet, skin allergies, or scars on your skin. You will find that the natural ingredients used to make this cream are good moisturizers for your skin and help keep it healthy.
In conclusion, it’s true that neuropathy in feet can be treated with CBD oil and cream. The oil and cream are made of natural ingredients that help relieve pain, inflammation, and stiffness. They also help cure scars left by injuries or accidents.
Furthermore, the maximum strength CBD cream helps with faster absorption in your skin to provide quick relief from daily discomfort.
However, it’s important to buy a cream that contains ingredients like menthol or camphor as these give a cooling sensation and will make you feel better for a longer period of time.
CBD for Peripheral Neuropathy: How Does It Work?
Good foot health is absolutely imperative for anyone who leads an active lifestyle. Composed of 26 bones, 33 joints, and more than 100 ligaments, muscles, and tendons, the feet are sophisticated structures that provide support, help to promote proper balance, and impact wellness. On that note, it’s important to take care of your trotters!
Cannabidiol (CBD), a non-intoxicating cannabinoid that boasts anti-inflammatory and pain-reducing properties, is emerging as an aid for foot care. Before CBD oil gets into action inside the body, it first reacts with the body’s internal endocannabinoid system (ECS) to produce a wide range of effects, including potential relief from peripheral neuropathic pain.
Cannabis may be an acceptable alternative to other potential pain relievers (like opioids) for the treatment of peripheral neuropathic pain. Since the side effects of CBD are mild to nonexistent, it serves as a welcome choice for people with sensory, motor, or autonomic nerve impairment.
Causes of Peripheral Neuropathic Pain
Peripheral neuropathy occurs when the nerves found outside of the brain and spinal cord—otherwise known as the peripheral nerves—become negatively inflicted. Alternatively, this chronic condition may occur when the nervous system becomes damaged. Many people who endure peripheral neuropathic pain will complain of an electric shock-type feeling.
According to the National Institute of Neurological Disorders and Stroke (NINDS), 20 million people are diagnosed with peripheral neuropathic pain. The majority of cases cause pain, numbness, weakness, burning, or shooting pains in the feet. Spontaneous pain of this kind tends to arise without a primary cause. The uncomfortable condition might also prompt circulation, digestion, and urination problems.
Diabetes is a common cause of neuropathy, with over 70% of diabetes patients developing painful symptoms. Blood sugar should be managed to reduce the risk of diabetes and diabetic neuropathy. Aside from diabetes, various other things may cause peripheral neuropathy, such as toxin exposure, chemotherapy, alcoholism, lack of vitamin B12, traumatic injury, and various types of nerve-damaging medication. If a doctor is unable to figure out the cause, it is known as “idiopathic neuropathy.”
How Does CBD for Neuropathy Work?
Oil-based CBD-infused topical creams work by blocking pain signals that are released from the damaged nerves. As a result, a person using CBD for neuropathy feels less discomfort. This is particularly true since CBD is a natural anti-inflammatory. Based on the results of a 2016 study on rodent models of arthritis, topical CBD successfully reduced pain and inflammation.
Furthermore, a more recent randomized controlled trial that was carried out in 2020 found that topical CBD solutions containing 250 milligrams CBD per 3 fluid ounces may offer relief for people who suffer from peripheral neuropathy. The study authors assessed 29 patients with symptomatic peripheral neuropathy, 15 of whom were treated with CBD and 14 of whom received a placebo.
By analyzing the Neuropathic Pain Scale (NPS), the research team learned that transdermal CBD application can drastically reduce pain and other unpleasant sensations associated with peripheral neuropathy.
Making a CBD Foot Soak From Home
Although you could visit a specialist spa—many CBD-focused spas are cropping up across the world right now, with Europe’s first establishment of this kind opening in Switzerland recently—the convenience of making a CBD foot soak from home may prove difficult to resist. When the soak is followed by a generous slathering of CBD-enriched oil, there really is no better way to indulge your hard-working feet.
So, how do you make a CBD foot soak from home? Begin by filling your chosen vessel with cold or warm water. Next, add a water-soluble CBD product, such as CBD-infused bath salts or bath bombs. These products work by fizzing when they hit the water, which results in the product’s infused essential oils and scent being released into the skin. Finally, prepare some snacks and enjoy!
Paying attention to what you eat could drastically reduce your chances of developing peripheral neuropathy in the first place. After all, as the old saying goes, “you are what you eat.” That being said, you ought to steer clear of foods that contain refined grains, high amounts of sugar, and artificial sweeteners since these foods can amplify nerve pain.
Studies like this one have demonstrated that an active lifestyle fueled by a low-fat diet that is rich in whole foods can positively influence neuropathy. Combine that with the use of CBD, and you can guarantee that your feet will thank you!